Nanostructures in transdermal drug delivery systems

Bibi, Najma; Ahmed, Naveed; Khan, Gul Majid

doi:10.1016/b978-0-323-46143-6.00021-x

Cited by 19 publications

(12 citation statements)

References 150 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The occlusiveness effect is dependent on the concentration of lipids, sample volume applied, particle size, and crystallinity of particles [ 83 ]. The succession of the above properties contributes to prevention of transepidermal water loss and opening of intergaps between corneocytes, promoting penetration of therapeutic agents deep into skin layers [ 84 ].…”

Section: Lipid Nanosystems Utilized In Skin Deliverymentioning

confidence: 99%

Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications

et al. 2023

View full text Add to dashboard Cite

Skin delivery is an exciting and challenging field. It is a promising approach for effective drug delivery due to its ease of administration, ease of handling, high flexibility, controlled release, prolonged therapeutic effect, adaptability, and many other advantages. The main associated challenge, however, is low skin permeability. The skin is a healthy barrier that serves as the body's primary defence mechanism against foreign particles. New advances in skin delivery (both topical and transdermal) depend on overcoming the challenges associated with drug molecule permeation and skin irritation. These limitations can be overcome by employing new approaches such as lipid nanosystems. Due to their advantages (such as easy scaling, low cost, and remarkable stability) these systems have attracted interest from the scientific community. However, for a successful formulation, several factors including particle size, surface charge, components, etc. have to be understood and controlled. This review provided a brief overview of the structure of the skin as well as the different pathways of nanoparticle penetration. In addition, the main factors influencing the penetration of nanoparticles have been highlighted. Applications of lipid nanosystems for dermal and transdermal delivery, as well as regulatory aspects, were critically discussed.

show abstract

Section: Lipid Nanosystems Utilized In Skin Deliverymentioning

confidence: 99%

Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Therefore, new topical formulations are required in order to increase MXD's residence time on the scalp's skin and hair follicle, thus decreasing the number of applications per day [23]. Among novel topical formulations, nanotechnology-based formulations have emerged as robust strategies for AGA management, owing to: (1) improved local accumulation of MXD; (2) minimized dermatological adverse effects and (3) the ability to permeate the stratum corneum [17,23,24].…”

Section: Conventional Formulations For Topical Delivery Of Minoxidilmentioning

confidence: 99%

“…Those structures are characterized by their ability to deform and permeate through the skin layers, without suffering noticeable decrease in the particle size, hence reaching the stratum corneum's deep layers [66]. The ability of transferosomes to deform is inherent in the edge activators, which act through the modification of the interfacial tension, allowing these vesicular nanoparticles to "squeeze" through intercellular spaces without losing their structure [24]. When compared to liposomes, transferosomes are more adaptable and may respond better in stress conditions [67].…”

Section: Transferosomesmentioning

confidence: 99%

Topical Minoxidil-Loaded Nanotechnology Strategies for Alopecia

et al. 2020

View full text Add to dashboard Cite

Androgenetic alopecia (AGA) is a multifactorial and age-related condition characterized by substantial hair loss affecting both men and women. Conventional treatments include the use of topical minoxidil (MNX) formulations to stimulate hair growth and restore hair condition. However, those treatments are associated with limited performance and a lack of tolerability and compliance due to the emergence of adverse effects. Considering that the development of nanotechnology-based formulations as hair loss therapeutic strategies has been clearly growing, topical MNX delivery by means of these innovative formulations is known to enhance MNX skin permeation and depot formation into hair follicles, allowing for MNX-controlled release, increased MNX skin bioavailability and enhanced therapeutic efficacy with minimal adverse effects. This review highlights the potential of nanotechnology-based MNX delivery formulations for improved hair loss therapeutics, including a thorough assessment of their in vitro and in vivo performances, as well as regulatory and nanosafety considerations.

show abstract

“…Transferosomes, familiarly known as "deformable liposomes, ultradeformable liposomes, flexible liposomes, ultraflexible liposomes, 2 nd generation vesicles, are stated by IDEA AG, Manich Germany to perform better than ordinary drug delivery systems, in the aspects of bioavailability and with low toxic effects (El-Zaafarany et al, 2010). Bibi et al, 2017;Kumavat et al, 2013) reported that transferosomal composition was biocompatible with biological cell membrane ,hence, they can be used for delivery of all categories of drugs. (Lu et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Neomycin sulphate loaded transferosomal vesicles

Allam

Annammadevi

2022

ijhs

View full text Add to dashboard Cite

The objective of research study was to fabricate neomycin sulphate loaded transferosomal vesicles by modified handshaking technique to increase the permeability of drug through vaginal mucosa. Tween80, span80, tween20, span20, Cremophor EL, brij35, sodium deoxycholate were used at three different concentrations by keeping drug concentration remains constant in all formulations. Stable vesicular formulation was obtained with span80 which is a better intercalatable surfactant in phospholipid layer, results also proved that that the fabricated neomycin sulphate loaded transferosomes were stabilized in terms of zetapotential +5mV homogenously dispersed with PDI value of 0.368 and particle size 152.8nm, entrapment efficiency values are 89.87%. Lipid extrusion test also concluded that fabricated neomycin sulphate loaded transferosomes were highly deformable in nature with deformability index value of 31.8. DSC of freeze dried nanosuspension results revealed that neomycin sulphate loaded transferosomes does not contain any peak related to neomycin sulphate could be due to complete loading of drug into vesicles, X-diffractogram patterns of a freeze dried nanosuspension also revealed that conversion of drug into loose lattice arrangement indicating amorphous nature of drug , in turn imposing loading more quantity of drug.

show abstract

Nanostructures in transdermal drug delivery systems

Cited by 19 publications

References 150 publications

Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications

Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications

Topical Minoxidil-Loaded Nanotechnology Strategies for Alopecia

Neomycin sulphate loaded transferosomal vesicles

Contact Info

Product

Resources

About