Nanosuspension: A Modern Approach In Drug Delivery System- A Review

Abstract

The drugs moiety included in Biopharmaceutical Classification System Class II and Class IV has low aqueous solubility and remedy for the solubility problem is nanotechnology techniques. Nanotechnology techniques play an important role at the molecular level and nano length scale size. To increase the dissolution rate of drug moiety which directly lead to increase bioavailability of drug depends on decrease drug particles into nano-scale range. Nanotechnology techniques in the pharmaceutical field include nanosuspension. Nanosuspension is biphasic dosage forms contain colloidal dispersions of nanosized drug particles which are stabilized by surface-active agents. Nanosuspension dosage form increases the stability and bioavailability of low aqueous soluble drugs. Solubility plays a crucial role in the effectiveness of drugs irrespective of the route of administration. Most of the presently investigated drug moieties having lower aqueous solubility and therefore has low bioavailability of drugs. The study is focused on formulation consideration, various methods of preparation along with evaluation parameters of nanosuspension.

Design and Development of Nanoemulsion of Smilax China for Anti-Psoriasis Activity

“…Accelerated stability studies were carried out on an optimized smilax china nanoemulsion according to International Conference on Harmonization (ICH) guidelines [50,51]. Sufficient replicates of the optimized nanoemulsions were kept at 40 °C±2 °C and 75%±5% RH.…”