Nanosuspension as Promising and Potential Drug Delivery: A Review

Abstract

In the last decade, nanosuspensions have gained considerable interest as a method for formulating poorly soluble drugs. Because of their cost-effectiveness and technological simplicity compared to liposomes and other colloidal drug carriers, nanoscale systems have recently received a lot of attention as a way of solving problems of solubility. Nanosuspensions are biphasic systems comprising of pure drug particles dispersed in an aqueous vehicle, stabilized by surface active agents. Fabrication of nanosuspension is simple and more advantageous than other approaches. Nanosuspension is a very finely single solid drug particle in an aqueous vessel, stabilized by surfactants for either oral or topical use or for parenteral and pulmonary administration, it can also be used for targeted drug delivery when incorporated in the ocular inserts and mucoadhesive hydrogels, with reduced particle size resulting in increased dissolution rate. This article covers the preparation of nanosuspension by bottom up technology, top down technology, melt emulsification, emulsification- solvent evaporation and supercritical fluid with their advantages and disadvantages, aspects of structure, classification and their drug delivery applications. Nanosuspension can be processed for the drugs which are of hydrophobic in nature quite easily employing stability enhancers, solvents that are of organic and additional ingredients including buffering agents, salts, PEG, osmotic agents and anti-freeze compounds.

Nanosuspension-Based Drug Delivery Systems for Topical Applications

“…The drug is then directed through the mill, which contains small grinding balls or pearls, within an aqueous solution. 38 , 39 These balls move through the interior of the grinding jar, striking the sample on the opposite grinding jar wall as they rotate at a very high shear rate, while the temperature is carefully controlled. A substantial reduction in particle size is achieved through the combined effects of friction and impact.…”

“…While there is limited toxicological data available at present, topically applied nanocrystals are not associated with known or anticipated adverse effects. 39 , 107…”

“…Collectively, the integration of drug nanocrystals into these alternative routes of drug administration represents a promising avenue for optimizing drug delivery, diversifying treatment options, and ultimately improving patient outcomes. 39 , 52 …”

Kajian Pengembangan Sediaan Nanosuspensi Untuk Penghantaran Intravena Obat Sukar Larut Air

“…Teknologi nanosuspensi juga dapat diaplikasikan untuk bahan aktif yang tidak larut dalah air juga dalam pelarut organik (7,9). Nanosuspensi dapat dibuat dengan dua metode yakni metode top down dan bottom up (11). Top down adalah pembentukan nanosuspensi dengan pengecilan ukuran partikel dari dispersi kasar menjadi sistem koloidal yang bisa dilakukan dengan teknik wet/dry milling, high pressure homogenization, dan co-grinding (12).…”

Central Composite Design Screened Mastic Gum Abetted Mucoadhesive Microspheres of Amoxicillin Trihydrate for Exterminating H. pylori

“…Dry AMMM were placed on a hygienic glass slide and measured under an eyepiece micrometer. A minimum of 200 AMMM were counted per batch [12,13].…”