Nanotechnological advances for the delivery of CNS therapeutics

Wong, Ho Lun; Wu, Xiao Yu; Bendayan, Reina

doi:10.1016/j.addr.2011.10.007

Cited by 442 publications

(295 citation statements)

References 197 publications

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“…Efficacious non-invasive treatment of neurological diseases is frequently limited by the poor access of therapeutic agents into the central nervous system (CNS) (Wong et al, 2012). The larger amount of drugs and biotechnological agents are not able to permeate readily into brain parenchyma due to the presence of two anatomical and biochemical dynamic barriers: the BBB and blood cerebrospinal fluid barrier (BCSFB).…”

Section: Lipid Nanoparticles and Nervous Systemmentioning

confidence: 99%

“…brain tumors, HIV encephalopathy, Alzheimer's disease and acute ischemic stroke. Future development of CNS nanomedicines needs to focus on increasing their drug-trafficking performance and specificity for brain tissue using novel targeting carriers, improving their BBB permeability and reducing their neurotoxicity (Wong et al, 2012).…”

Section: Lipid Nanoparticles and Nervous Systemmentioning

confidence: 99%

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Novel Neuroprotective Formulations Based on St. John’s Wort Extract

Vazzana¹,

Macedo²,

Santini³

et al. 2014

JFR

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St. John's Wort (SJW) has been intensively studied in the last years with respect to its pharmacological properties and to understand the mechanism of action of its bioactive compounds. In fact, it is currently used for the treatment of several disorders. Nevertheless, only recently nanotechnology has been applied for the delivery of SJW extract in vivo, to enhance its neuroprotective properties. In the present review, the advantages, the chemical characterization and the special biological features of SJW extract are discussed, underlining the potential use of nanotechnology in the development of drug carrier systems based on lipid nanoparticles. A special focus is given to solid lipid nanoparticles (SLN) and to nanostructured lipid carriers (NLC) given their versatility for a wide range of bioactive compounds.

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Section: Lipid Nanoparticles and Nervous Systemmentioning

confidence: 99%

Section: Lipid Nanoparticles and Nervous Systemmentioning

confidence: 99%

Novel Neuroprotective Formulations Based on St. John’s Wort Extract

Vazzana¹,

Macedo²,

Santini³

et al. 2014

JFR

View full text Add to dashboard Cite

show abstract

“…Intranasal administration has the potential to circumvent the BBB via intracellular or extracellular pathways. The intracellular pathways include endocytosis (adsorptive or receptor mediated) into olfactory sensory neurons followed by intraneuronal transport (transcytosis) into trigeminal nerves whereas, extracellular pathways include paracellular diffusion to the lamina propria through perineural or perivascular channels [88,89]. Intranasal administrations offer benefits like rapid onset of action and reduced systemic toxicities for delivering the therapeutics to the brain.…”

Section: Routes Of Administration To Enhance Drug Delivery Across Bbbmentioning

confidence: 99%

Nanotechnology platforms in Parkinson’s Disease

2015

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Parkinson's disease (PD) remains a serious concern due to its effects on the quality of life of patients and its socioeconomic burden to society. Present day management of PD has limitations in both diagnosis and treatment. Nanotechnology may provide smart solutions to this problem. The present review highlights the recent advancements in the development of nanotechnology platforms for PD. The review focuses on the use of such platforms in diagnostics, treatments, deep brain stimulation, neurosurgery and other

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“…32 As a drug carrier, SLNs offer unique properties such as small size, large surface area, and high loading properties, and are attractive for their potential to improve the performance of oral pharmaceuticals against stroke. 38 …”

Section: Nano-carriers For Cns Drug Deliverymentioning

confidence: 99%

Therapeutic Potential of Natural Product-Based Oral Nanomedicines for Stroke Prevention

Mutoh

Taki

et al. 2016

Journal of Medicinal Food

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Cerebral stroke is the leading cause of death and permanent disability in elderly persons. The impaired glucose and oxygen transport to the brain during ischemia causes bioenergetic failure, leading to oxidative stress, inflammation, bloodbrain barrier dysfunction, and eventually cell death. However, the development of effective therapies against stroke has been hampered by insufficient oral absorption of pharmaceuticals and subsequent delivery to the brain. Nanotechnology has emerged as a new method of treating cerebral diseases, with the potential to fundamentally change currently available therapeutic approaches using compounds with low bioavailability. This perspective review provides an overview of the therapeutic potential of oral nanomedicines for stroke, focusing on novel natural product-loaded delivery system with potent antioxidant and anti-inflammatory effects.

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Nanotechnological advances for the delivery of CNS therapeutics

Cited by 442 publications

References 197 publications

Novel Neuroprotective Formulations Based on St. John’s Wort Extract

Novel Neuroprotective Formulations Based on St. John’s Wort Extract

Nanotechnology platforms in Parkinson’s Disease

Therapeutic Potential of Natural Product-Based Oral Nanomedicines for Stroke Prevention

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