Nanotechnologies in Drug Delivery - An Industrial Perspective

Bazile, Didier

doi:10.1016/s1773-2247(14)50002-0

Cited by 31 publications

(28 citation statements)

References 80 publications

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“…It is recommended to design nanosystems using the simplest procedure/platform possible, and taking into account the ADME parameters, since this is fundamental to ensuring the safety and efficacy of the nanomaterial (absorption, distribution, metabolism, and elimination) [7,33]. An efficient methodology to perform the physicochemical characterization of nanomaterials is applying chemical manufacturing and control (CMC) practices to ensure the quality of the nanoproduct, although CMC practices applied to nanomedicine products do not already exist [33].…”

Section: Development Of Novel Nanomedicinesmentioning

confidence: 99%

“…In this context, nanomedicines can be included in the field of “precision medicine,” which consists of a very sensitive diagnosis and targeted treatment of diseases [3]. Nanomedicines are also reported as nanodrugs, nanocarriers, nanoconstructs, nanoparticles, nanomaterials, or nanotherapeutics [7,8,9,10,11,12,13]. In general, the terms “nanomaterial” and “nanosystem” include a wide variety of objects with at least one dimension in the nanometric scale (typically 1–1000 nm) (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

“…In general, the terms “nanomaterial” and “nanosystem” include a wide variety of objects with at least one dimension in the nanometric scale (typically 1–1000 nm) (Figure 1). The term nanomedicine appeared in the 1990s, and since then, its interest has experienced an exponential increase within the scientific community, notably during the last 20 years, after the government of the United States announced that it was starting to fund nanomedicinal studies [7,8,14,15,16,17,18,19,20,21]. More recently, the European Technology platform on Nanomedicine (ETPN) defined the term “nanomedicine” as: “The application of nanotechnology to achieve breakthroughs in healthcare that exploits the improved and often novel physical, chemical and biological properties of materials at the nanometer scale” [4].…”

Section: Introductionmentioning

confidence: 99%

“…In Europe, the first nanomedicine product approved by the EMA was AmBisome, a liposomal nanoformulation encapsulating amphotericin B for the treatment of fungal infections [4,7,34,36,37]. Since then, the number of nanomedicine studies has increased exponentially and, currently, papers and patents are numerous.…”

Section: Introductionmentioning

confidence: 99%

“…Doxil is still one of the most used nowadays, but many other anticancer nanoformulations have been approved, such as Oncoprex, a lipid nanoparticle containing plasmid DNA that encodes for TUSC2 , a tumor suppressor gene, in Phase II for the treatment of lung cancer in combination with Erlotinib; and Abraxane, albumin nanoparticles encapsulating paclitaxel for the treatment of various types of tumors (see Table 2) [7,12,32,33,34,43,44,45]. …”

Section: Introductionmentioning

confidence: 99%

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Personalized Nanomedicine: A Revolution at the Nanoscale

Fornaguera

García-Celma

2017

JPM

132

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Nanomedicine is an interdisciplinary research field that results from the application of nanotechnology to medicine and has the potential to significantly improve some current treatments. Specifically, in the field of personalized medicine, it is expected to have a great impact in the near future due to its multiple advantages, namely its versatility to adapt a drug to a cohort of patients. In the present review, the properties and requirements of pharmaceutical dosage forms at the nanoscale, so-called nanomedicines, are been highlighted. An overview of the main current nanomedicines in pre-clinical and clinical development is presented, detailing the challenges to the personalization of these therapies. Next, the process of development of novel nanomedicines is described, from their design in research labs to their arrival on the market, including considerations for the design of nanomedicines adapted to the requirements of the market to achieve safe, effective, and quality products. Finally, attention is given to the point of view of the pharmaceutical industry, including regulation issues applied to the specific case of personalized medicine. The authors expect this review to be a useful overview of the current state of the art of nanomedicine research and industrial production, and the future opportunities of personalized medicine in the upcoming years. The authors encourage the development and marketing of novel personalized nanomedicines.

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Section: Development Of Novel Nanomedicinesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Personalized Nanomedicine: A Revolution at the Nanoscale

Fornaguera

García-Celma

2017

JPM

132

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Biohybrid Nanoparticles to Negotiate with Biological Barriers

Mohammadi

Corbo

Molinaro

et al. 2019

Small

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Incapability of effective cross-talk with biological environments has partly impaired the in vivo functionality of nanoparticles (NPs). Homing, biodistribution, and function of NPs could be engineered through regulating their interactions with in vivo niches. Inspired by communications in biological systems, endowing a "biological identity" to synthetic NPs is one approach to control their biodistribution, and immunonegotiation profiles. This syntheticbiological combination is referred to as biohybrid NPs, which comprise both i) engineerable, readily producible, and trackable synthetic NPs as well as ii) biological moieties with the capability to cross-talk with immunological barriers. Here, the latest understanding on the in vivo interactions of NPs, biological barriers they face, and emerging methods for quantitative measurements of NPs' biodistribution are reviewed. Some key biomolecules that have emerged as negotiators with the immune system in the context of cancer and autoimmunity, and their inspirations on biohybrid NPs are introduced. Critical design considerations for efficient cross-talk between NPs and innate and adaptive immunity followed by hybridization methods are also discussed. Finally, clinical translation challenges and future perspectives regarding biohybrid NPs are discussed.

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