Nanotechnology and sialic acid biology

Ghosh, Shyamasree

doi:10.1016/b978-0-12-816126-5.00011-1

Cited by 5 publications

(4 citation statements)

References 127 publications

(129 reference statements)

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“…pPS-NPs bind to the anionic headgroup of phospholipids or other negatively charged molecules such as sialic acids in membrane proteins . The sialic acid moiety is abundantly expressed in human alveolar cells and serves as the docking site for the viral entry . In comparison to nPS-NPs, the larger electrostatic interactions of pPS-NPs resulted in their more effective internalization followed by the increase in intracellular ROS levels.…”

Section: Discussionmentioning

confidence: 99%

Surface Charge-Dependent Cytotoxicity of Plastic Nanoparticles in Alveolar Cells under Cyclic Stretches

et al. 2020

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Polystyrene nanoparticles (PS-NPs) derived from both environmental and occupational sources are an important class of ultrafine particles associated with human pulmonary disorders. The effects of surface charges of particle internalization and toxicity to alveolar cells, especially under conditions comparable to those found during breathing, have not been examined. Here, we applied cyclic stretches (CS) to human alveolar cells during nanoparticle exposure and show an enhanced accumulation of positively charged polystyrene nanoparticles as compared to similar negatively charged particles. The cellular uptake of the positive particles into live cells was visualized with three-dimensional optical diffraction tomography (3-D ODT). The simultaneous application of both periodic stretching as well as positively charged nanoparticles led to blebbing morphology and activation of apoptotic signaling compared to control cells. Our findings provide a better understanding of how surface charge mediates the uptake and toxicity of nanoplastics under the dynamical mechanical conditions relevant for breathing exposures.

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Section: Discussionmentioning

confidence: 99%

Surface Charge-Dependent Cytotoxicity of Plastic Nanoparticles in Alveolar Cells under Cyclic Stretches

et al. 2020

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“…[86][87][88][89][90][91][92][93] Many different scaffolds have been used to chemically attach sialic acid, including antibodies, DNA, fullerenes, graphene, polyacrylamide, quantum dots, magnets, silver and gold nanoparticles, although biocompatibility and potential toxicological liabilities of all of these remain and none have progressed to approval for use in humans. 76,94 Controlling the spatial distribution and number of ligand-bearing units in these oligomers can also be sub-optimal and/or ill-defined, leading to reduced binding or promiscuous binding to other sialic acid receptors (Table 1). The lack of target specificity can lead to faster in vivo clearance rates and may also explain reported toxicities for many polymeric inhibitors.…”

Section: Sialic Acid Receptors Of Virusesmentioning

confidence: 99%

The therapeutic potential of sialylated Fc domains of human IgG

Pleass

2021

mAbs

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Pathogens frequently use multivalent binding to sialic acid to infect cells or to modulate immunity through interactions with human sialic acid-binding immunoglobulin-type lectins (Siglecs). Molecules that interfere with these interactions could be of interest as diagnostics, anti-infectives or as immune modulators. This review describes the development of molecular scaffolds based on the crystallizable fragment (Fc) region of immunoglobulin (Ig) G that deliver high-avidity binding to innate immune receptors, including sialic acid-dependent receptors. The ways in which the sialylated Fc may be engineered as immune modulators that mimic the anti-inflammatory properties of intravenous polyclonal Ig or as blockers of sialic-acid-dependent infectivity by viruses are also discussed.

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“…A promising alternative is the use of multivalent display of mimetics onto a nanoparticles, liposomes or polymers [ 96 ] ( Figure 7 ). Bio-orthogonal synthesis is enabling the presentation of modified sialic acids on nanoparticles, polymers, and living cells [ 97 , 98 ].…”

Section: Modified Sialic Acids Targeting Siglecsmentioning

confidence: 99%

Current Status on Therapeutic Molecules Targeting Siglec Receptors

Lenza

Atxabal

Oyenarte

et al. 2020

Cells

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The sialic acid-binding immunoglobulin-type of lectins (Siglecs) are receptors that recognize sialic acid-containing glycans. In the majority of the cases, Siglecs are expressed on immune cells and play a critical role in regulating immune cell signaling. Over the years, it has been shown that the sialic acid-Siglec axis participates in immunological homeostasis, and that any imbalance can trigger different pathologies, such as autoimmune diseases or cancer. For all this, different therapeutics have been developed that bind to Siglecs, either based on antibodies or being smaller molecules. In this review, we briefly introduce the Siglec family and we compile a description of glycan-based molecules and antibody-based therapies (including CAR-T and bispecific antibodies) that have been designed to therapeutically targeting Siglecs.

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Nanotechnology and sialic acid biology

Cited by 5 publications

References 127 publications

Surface Charge-Dependent Cytotoxicity of Plastic Nanoparticles in Alveolar Cells under Cyclic Stretches

Surface Charge-Dependent Cytotoxicity of Plastic Nanoparticles in Alveolar Cells under Cyclic Stretches

The therapeutic potential of sialylated Fc domains of human IgG

Current Status on Therapeutic Molecules Targeting Siglec Receptors

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