Nanotechnology application in drug delivery to osteoarthritis (OA), rheumatoid arthritis (RA), and osteoporosis (OSP)

Rabiei, Morteza; Kashanian, Soheila; Samavati, Seyedeh Sabereh; Derakhshankhah, Hossein; Jamasb, Shahriar; McInnes, Steven J. P.

doi:10.1016/j.jddst.2020.102011

Cited by 40 publications

(22 citation statements)

References 69 publications

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“…All methods have many drawbacks such as low precision, poor image resolution, and high cost, despite the extensive use of conventional methods in the diagnosis of arthritis. However, important progress in nanomedicine has been made recently and new platforms for high precision diagnosis of inflammatory arthritis can be introduced by nanotechnology [ 97 , 98 ].…”

Section: Nanomaterials For the Diagnosis Of Inflammatory Arthritismentioning

confidence: 99%

“…For example, RF and anti-CCP are used for inflammatory arthritis diagnosis based on EULAR 2010 guidelines [ 115 ]. The most promising alternative for the future diagnosis and treatment of inflammatory arthritis are actually NPs [ 97 ]. Nanomaterials such as quantum dots, carbon nanoallotropes, micelles, and liposomes will be discussed in following paragraphs ( Figure 1 ).…”

Section: Nanomaterials For the Diagnosis Of Inflammatory Arthritismentioning

confidence: 99%

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Nanomaterials for the Diagnosis and Treatment of Inflammatory Arthritis

Hosseinikhah

Barani

Rahdar

et al. 2021

IJMS

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Nanomaterials have received increasing attention due to their unique chemical and physical properties for the treatment of rheumatoid arthritis (RA), the most common complex multifactorial joint-associated autoimmune inflammatory disorder. RA is characterized by an inflammation of the synovium with increased production of proinflammatory cytokines (IL-1, IL-6, IL-8, and IL-10) and by the destruction of the articular cartilage and bone, and it is associated with the development of cardiovascular disorders such as heart attack and stroke. While a number of imaging tools allow for the monitoring and diagnosis of inflammatory arthritis, and despite ongoing work to enhance their sensitivity and precision, the proper assessment of RA remains difficult particularly in the early stages of the disease. Our goal here is to describe the benefits of applying various nanomaterials as next-generation RA imaging and detection tools using contrast agents and nanosensors and as improved drug delivery systems for the effective treatment of the disease.

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Section: Nanomaterials For the Diagnosis Of Inflammatory Arthritismentioning

confidence: 99%

Section: Nanomaterials For the Diagnosis Of Inflammatory Arthritismentioning

confidence: 99%

Nanomaterials for the Diagnosis and Treatment of Inflammatory Arthritis

Hosseinikhah

Barani

Rahdar

et al. 2021

IJMS

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“…Natural polymers possess intrinsic properties to mimic biological system and specifically interact with receptors so can be utilized for targeting therapy. 40 Hyaluronic acid (HA) specifically targets CD44 receptors overexpressed in synovial fluid utilized for delivery of salmon calcitonin. HA enhanced retention of calcitonin at inflamed joint and enhanced osteoprotective function as compared to free drug in animal models.…”

Section: Figure 3: Drug Penetration Pathways Through the Skin Nanocarriers For Transdermal Delivery Of Nsaidsmentioning

confidence: 99%

Emerging role of chondroitin sulfate based nanocarriers in improving the therapeutic outcome of NSAIDs in the treatment of osteoarthritis through the TDDDS

Gul

Jahan

Naseer

2021

JSTMU

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Osteoarthritis is characterized by joint destruction followed by severe inflammation caused by variety of proinflammatory mediators released due to upregulation of nuclear translocation of nuclear factor (NF-kB). Current treatment involves chronic administration of non-steroidal anti-inflammatory drugs (NSAIDs) that is associated with bewildering array of systemic adverse effects. Transdermal drug delivery system address challenges of systemic toxicities but toxic chemical penetration enhancers limit its utility. Novel drug delivery system explores the potential of bio-inspired materials for designing of safe and effective carriers that specifically deliver drug to site of action with enhanced transdermal penetration of the drug. Chondroitin sulfate, a biopolymer that mimic extracellular matrix, binds specifically with its overexpressed receptors (CD44, RHAMM and ICAM-I) at inflammatory site, biodegradable and possess intrinsic anti-inflammatory properties. These attributes render chondroitin sulfate an ideal carrier for the drug delivery in osteoarthritis. Chondroitin sulfate based nanocarriers serve as a potential drug delivery system that not only deliver anti-arthritis drug through the skin but also produce synergistic effect to improve therapeutic outcome. In this review, molecular mechanism of intrinsic anti-inflammatory effects of chondroitin sulfate in osteoarthritis is discussed in detail. Moreover, potential of chondroitin sulfate to perform dual role of therapeutic agent as well as serve as nanocarrier in transdermal drug delivery for the treatment of osteoarthritis is elaborated.

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“…The most recurrent symptom associated with RA (an autoimmune disorder) is joint pain, leading to decreased motility, sleep disturbance, physical disability, increased health-related costs, and ultimately to lifelong inflammatory complications. 2 , 3 Several pro-inflammatory cytokines including TNF-α, IL-1β and IL-6 are activated in RA. 4 The effective treatment of active RA relies on the biological targeting of these cytokines with a suitable drug regimen.…”

Section: Introductionmentioning

confidence: 99%

Nanoemulgel, an Innovative Carrier for Diflunisal Topical Delivery with Profound Anti-Inflammatory Effect: in vitro and in vivo Evaluation

Bashir

Ahmad

Asif

et al. 2021

IJN

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Purpose Rheumatoid arthritis is an autoimmune disorder that directly affects joints. However, other body organs including heart, eyes, skin, blood vessels and lungs may also be affected. The purpose of this study was to design and evaluate a nanoemulgel formulation of diflunisal (DIF) and solubility enhanced diflunisal (DIF-IC) for enhanced topical anti-inflammatory activity. Methodology Nanoemulsion formulations of both DIF and DIF-IC were prepared and incorporated in three different gelling agents, namely carboxymethylcellulose sodium (CMC-Na), sodium alginate (Na-ALG) and xanthan gum (XG). All the formulations were evaluated in term of particle size, pH, conductivity, viscosity, zeta potential and in vitro drug release. The formulation 2 (NE2) of both DIF and DIF-IC which expressed optimum release and satisfactory physicochemical properties was incorporated with gelling agents to produce final nanoemulgel formulations. The optimized nanoemulgel formulation was subjected to three different in vivo anti-inflammatory models including carrageenan-induced paw edema model, histamine-induced paw edema model and formalin-induced paw edema model. Results DIF-IC-loaded nanoemulgel formulations yielded significantly enhanced in vitro skin permeation than DIF-loaded nanoemulgel. The nanoemulgel formulation of DIF-IC formulated with XG produced improved in vivo anti-inflammatory activity. Conclusion It was recommended that DIF-IC-based nanoemulgel formulation prepared with XG could be a better option for effective topical treatment of inflammatory conditions.

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Nanotechnology application in drug delivery to osteoarthritis (OA), rheumatoid arthritis (RA), and osteoporosis (OSP)

Cited by 40 publications

References 69 publications

Nanomaterials for the Diagnosis and Treatment of Inflammatory Arthritis

Nanomaterials for the Diagnosis and Treatment of Inflammatory Arthritis

Emerging role of chondroitin sulfate based nanocarriers in improving the therapeutic outcome of NSAIDs in the treatment of osteoarthritis through the TDDDS

Nanoemulgel, an Innovative Carrier for Diflunisal Topical Delivery with Profound Anti-Inflammatory Effect: in vitro and in vivo Evaluation

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