Nanotechnology-based photoimmunological therapies for cancer

Li, Yong; Li, Xiaosong; Zhou, Feifan; Doughty, Austin; Hoover, Ashley R.; Nordquist, Robert E.; Chen, Wei R.

doi:10.1016/j.canlet.2018.10.044

Cited by 68 publications

(39 citation statements)

References 121 publications

(117 reference statements)

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“…Light has been used in the clinical setting since the beginning of the 20th century, and phototherapies have been widely used to treat skin diseases (such as lupus) and cancers [109,110]. Currently, phototherapies are divided into photodynamic therapy (PDT) and photothermal therapy (PTT).…”

Section: Photo-chemotherapymentioning

confidence: 99%

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

et al. 2020

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Nanogel-based nanoplatforms have become a tremendously promising system of drug delivery. Nanogels constructed by chemical crosslinking or physical self-assembly exhibit the ability to encapsulate hydrophilic or hydrophobic therapeutics, including but not limited to small-molecule compounds and proteins, DNA/RNA sequences, and even ultrasmall nanoparticles, within their 3D polymer network. The nanosized nature of the carriers endows them with a specific surface area and inner space, increasing the stability of loaded drugs and prolonging their circulation time. Reactions or the cleavage of chemical bonds in the structure of drug-loaded nanogels have been shown to trigger the controlled or sustained drug release. Through the design of specific chemical structures and different methods of production, nanogels can realize diverse responsiveness (temperature-sensitive, pH-sensitive and redox-sensitive), and enable the stimuli-responsive release of drugs in the microenvironments of various diseases. To improve therapeutic outcomes and increase the precision of therapy, nanogels can be modified by specific ligands to achieve active targeting and enhance the drug accumulation in disease sites. Moreover, the biomembrane-camouflaged nanogels exhibit additional intelligent targeted delivery features. Consequently, the targeted delivery of therapeutic agents, as well as the combinational therapy strategy, result in the improved efficacy of disease treatments, though the introduction of a multifunctional nanogel-based drug delivery system.

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Section: Photo-chemotherapymentioning

confidence: 99%

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

et al. 2020

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“…A safe and effective immunotherapy with great controllability and sensitivity can be achieved by developing novel drug delivery platforms based on nanotechnology and material science. [264][265][266][267][268][269][270] The cascaded synergistic effects of photodynamic-immunotherapy can provide a promising strategy to inhibit both primary lesions and distant metastases, which can be hardly achieved by conventional PDT with limited immunologic effects. [256] Moreover, the combination of immunotherapy and PDT has attracted an increasing attention due to the potential systematic antitumor immunity after PDT.…”

Section: Postoperative Immunotherapy For Long-term Antitumor Effectsmentioning

confidence: 99%

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

et al. 2019

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Surgical resection is the primary and most effective treatment for most patients with solid tumors. However, patients suffer from postoperative recurrence and metastasis. In the past years, emerging nanotechnology has led the way to minimally invasive, precision and intelligent oncological surgery after the rapid development of minimally invasive surgical technology. Advanced nanotechnology in the construction of nanomaterials (NMs) for precision imaging-guided surgery (IGS) as well as surgery-assisted synergistic therapy is summarized, thereby unlocking the advantages of nanotechnology in multimodal IGS-assisted precision synergistic cancer therapy. First, mechanisms and principles of NMs to surgical targets are briefly introduced. Multimodal imaging based on molecular imaging technologies provides a practical method to achieve intraoperative visualization with high resolution and deep tissue penetration. Moreover, multifunctional NMs synergize surgery with adjuvant therapy (e.g., chemotherapy, immunotherapy, phototherapy) to eliminate residual lesions. Finally, key issues in the development of ideal theranostic NMs associated with surgical applications and challenges of clinical transformation are discussed to push forward further development of NMs for multimodal IGS-assisted precision synergistic cancer therapy.

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“…When summarizing a large number of reports from photothermal‐immunotherapy, we found that control of photothermal temperature was very important for enhancing the immunogenicity of the tumor. It was generally believed that 39–42°C was beneficial for the induction of ICD (Li, Li, et al, ; Toraya‐Brown & Fiering, ). When the temperature was higher (>50°C), it showed no selection in killing cancer cells and non‐cancerous stromal cells (Toraya‐Brown & Fiering, ).…”

Section: Nanomaterials For the Regulation Of Cancer Immunity Cyclementioning

confidence: 99%

Regulation of cancer‐immunity cycle and tumor microenvironment by nanobiomaterials to enhance tumor immunotherapy

Yang

Zhang

2020

WIREs Nanomed Nanobiotechnol

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In the past decade, we have witnessed the revolution in cancer therapy, especially in the rapid development of cancer immunotherapy. In particular, the introduction of nanomedicine has achieved great improvement in breaking the limitations of and immunological tolerance caused by clinic‐approved immunotherapies (cancer vaccine, CAR‐T, and immune checkpoint blockade) to enhance immunogenicity, antigen presentation and T lymphocyte infiltration for eradicating the primary tumors and distant metastases simultaneously. However, some fundamental but significant issues still need to be thoroughly clarified before the combination of nanomedicine and immunotherapy moves toward clinical translation such as biological safety and synergistic mechanisms of nanomaterials in the systematic immune responses. Therefore, in this review, the role of nanomaterials in cancer immunotherapy is summarized, mainly focusing on the effective activation and long‐term stimulation of both the innate and the adaptive immune responses and regulation of or remodeling the tumor microenvironment, especially the tumor immunosuppressive microenvironment. Also, we elaborate on the targets and challenges of nanomaterials in the cancer‐immunity cycle, summarize several main strategies to convert the cold tumor immune microenvironment to the hot one, and illustrate the progress in regulation of tumor immune microenvironment by targeting specific immunosuppressive cells. Finally, we prospect the nano‐combined immunotherapy strategies in tumor‐targeting, normalization of tumor immune environment and modification of macrophages. This article is characterized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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Nanotechnology-based photoimmunological therapies for cancer

Cited by 68 publications

References 121 publications

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

Regulation of cancer‐immunity cycle and tumor microenvironment by nanobiomaterials to enhance tumor immunotherapy

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