Nanotechnology for delivery of natural therapeutic substances: a review

Raju, S.; Chella, Naveen

doi:10.1007/s10311-020-01103-9

Cited by 49 publications

(23 citation statements)

References 59 publications

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“…Over past decades, resistance to antibiotics has become increasingly widespread and resulted in noteworthy deaths of humans. The emergence and re-emergence of pathogens have become a major public health concern worldwide, and the rapid emergence of antibiotic-resistant Gram-positive and Gram-negative pathogenic germs is a major public health concern [130][131][132][133][134]. The long list of drug-resistant bacteria includes macrolideresistant Streptococcus pyogenes, sulfonamide, penicillin, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus, penicillin-resistant Streptococcus pneumoniae, multi-drug resistant Mycobacterium tuberculosis (MDR-M. tuberculosis), penicillinresistant Neisseria gonorrhoeae (PRNG), E. coli, E. cloacae, K. pneumoniae, Salmonella enterica, Shigella flexneri, Acinetobacter baumannii, Vibrio cholerae, P. aeruginosa, and beta-lactamaseexpressing Haemophilus influenzae.…”

Section: Applications Of Phytofabricated Nps As Nanoantibioticsmentioning

confidence: 99%

Recent Advances in Green Synthesis, Characterization, and Applications of Bioactive Metallic Nanoparticles

Begum

Pratibha²,

Rawat

et al. 2022

Pharmaceuticals

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Nanoparticles (NPs) are elements derived from a cluster of atoms with one or more dimensions in the nanometer scale in the range of 1–100 nm. The bio nanofabrication of metallic NPs is now an important dynamic area of research, with major significance in applied research. Biogenic synthesis of NPs is more desirable than physical and chemical synthesis due to its eco-friendliness, non-toxicity, lower energy consumption, and multifunctional nature. Plants outperform microorganisms as reducing agents as they contain large secondary biomolecules that accelerate the reduction and stability of the NPs. The produced NPs can then be studied spectroscopically (UV-Visible, XRD, Raman, IR, etc.) and microscopically (SEM, TEM, AFM, etc.). The biological reduction of a metallic ion or its oxide to a nanoparticle is quick, simple, and may be scaled up at room temperature and pressure. The rise in multi-drug resistant (MDR) microbes due to the immoderate use of antibiotics in non-infected patients is a major cause of morbidity and mortality in humans. The contemporary development of a new class of antibiotics with different mechanisms of action to kill microbes is crucial. Metals and their oxides are extremely toxic to microbes at unprecedentedly low concentrations. In addition, prevailing infections in plants and animals are raising significant concerns across the globe. NPs’ wide range of bioactivity makes them ideal antimicrobial agents in agricultural and medical fields. The present review outlines the synthesis of metallic NPs from botanicals, which enables the metals to be in a stabilized form even after ionization. It also presents a valuable database on the biofunctionalization of synthesized NPs for further drug development.

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Section: Applications Of Phytofabricated Nps As Nanoantibioticsmentioning

confidence: 99%

Recent Advances in Green Synthesis, Characterization, and Applications of Bioactive Metallic Nanoparticles

Begum

Pratibha²,

Rawat

et al. 2022

Pharmaceuticals

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“…Nanotechnology is a new field of interdisciplinary investigation, and has been widely used in the diagnosis and treatment of diseases (Saka and Chella, 2020). MPEG and PLGA are two biodegradable materials approved by the United Satates Food and Drug Administration for human use.…”

Section: Discussionmentioning

confidence: 99%

Curcumin-Loaded mPEG-PLGA Nanoparticles Attenuates the Apoptosis and Corticosteroid Resistance Induced by Cigarette Smoke Extract

et al. 2022

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The present study was aim to prepare curcumin-loaded methoxypolyethylene-glycols-poly (lactic-co-glycolic acid) nanoparticles (Cur-mPEG-PLGA-NPs) and investigate curcumin’s effect on reversing corticosteroid resistance induced by cigarette smoke extract (CSE) in rat tracheal epithelial (RTE) cells. The Cur-mPEG-PLGA-NPs were spherical, regular in shape with smooth surfaces, and well distributed and Cur-mPEG-PLGA-NP suspensions had good water solubility and presented prolonged release. Furthermore, we found that Cur-mPEG-PLGA-NPs were internalized more than curcumin into the cells and significantly alleviated apoptosis in RTE cells. In addition, 10% CSE reduced the maximal inhibition percentage and increased the half-inhibitory concentration of budesonide (BUD) on IL-8 secretion, and curcumin restored the efficacy of BUD inhibition. BUD in combination with Cur-mPEG-PLGA-NPs showed higher inhibitory rates for LPS- and CSE-induced IL-8 secretion than that in combination with curcumin. Moverover, the relative expression levels of HDAC2 was reduced after CSE exposure and curcumin could improve HDAC2 expression and reverse CSE-induced corticosteroid resistance. Curcumin in high concentration and Cur-mPEG-PLGA-NPs restored HDAC2 levels in RTE cells and thus Cur-mPEG-PCL-NPs have higher biological activity than curcumin.

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“…Diverse strategies have been used to optimise the bioavailability of natural products (Dragicevic & Maibach 2016;Jain & Chella 2020;Paroha et al 2020;Saka et al 2020). They are mainly chemical strategies producing semisynthetic compounds or synthetic analogues (Fang & Leu 2006;Ita 2016), but recently there is an increasing interest in developing appropriate formulations, specifically nanodelivery systems, which present numerous advantages in comparison to conventional drug formulations, such as controlled release kinetics, targeted delivery, enhanced solubility and permeation, increased chemical and physical stability, and…”

Section: Introductionmentioning

confidence: 99%

Recent strategies in nanodelivery systems for natural products: a review

Vanti

2021

Environ Chem Lett

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Natural products are major molecules for drug discovery due to their structural diversity and their interaction with various biological targets, yet their clinical application is limited by poor water solubility or low lipophilicity, inappropriate molecular size, low dissolution rate and permeation, instability, high metabolic rate and rapid clearance. These issues can be solved by nanomedicine, by improving bioavailability and therapeutic efficacy. Here we review nanocarriers made of polymer or lipid constituents. Specifically, we describe the technological characteristics of each nanosystem, with examples of application to single natural constituents or plant extracts, and possible routes of administration. We report in vitro and in vivo studies and we conclude with the potential advantages of nanodelivery systems in terms of increased stability and solubility, improved biodistribution and efficacy, reduced adverse effects and toxicity.

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Nanotechnology for delivery of natural therapeutic substances: a review

Cited by 49 publications

References 59 publications

Recent Advances in Green Synthesis, Characterization, and Applications of Bioactive Metallic Nanoparticles

Recent Advances in Green Synthesis, Characterization, and Applications of Bioactive Metallic Nanoparticles

Curcumin-Loaded mPEG-PLGA Nanoparticles Attenuates the Apoptosis and Corticosteroid Resistance Induced by Cigarette Smoke Extract

Recent strategies in nanodelivery systems for natural products: a review

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