Nanotechnology for Early Cancer Detection

Choi, Yun Sung; Kwak, Ju-Won; Park, Chong-Yun

doi:10.3390/s100100428

Cited by 291 publications

(170 citation statements)

References 146 publications

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“…Cancer is a heterogeneous disease that rapidly progresses to an uncontrollable stage after onset [12,13]. Thus, the survival and quality of life of patients depend directly on the stage at which the cancer has been detected; the most important factor in cancer management therefore is the detection of cancer cells at an early stage.…”

Section: Nanoscale Diagnosis: Molecular and Cellular Selectionmentioning

confidence: 99%

The potential legacy of cancer nanotechnology: cellular selection

Patra

Turner

2014

Trends in Biotechnology

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Overexpression of oncogenes or loss of tumour suppressors can transform a normal cell to a cancerous one, resulting in uncontrolled regulation of intracellular signaling pathways and immunity to stresses, which both pose therapeutic challenges.Conventional approaches to cancer therapy, although they are effective at killing cancer cells, may still fail due to inadequate biodistribution and unwanted side effects.Nanotechnology-based approaches provide a promising alternative, with the possibility of targeting cells at an early stage, during their transformation into cancer cells. This review considers techniques that specifically target those molecular changes, which begin in only a very small percentage of normal cells as they undergo transformation. These techniques are crucial for 'early-stage' diagnosis and therapy.3

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Section: Nanoscale Diagnosis: Molecular and Cellular Selectionmentioning

confidence: 99%

The potential legacy of cancer nanotechnology: cellular selection

Patra

Turner

2014

Trends in Biotechnology

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“…In these sensors, receptor molecules with high specificity and strong binding affinity are anchored to the surface of CNTs to recognize the target biomarkers. Upon the binding of the biomarkers, the conductance of the semiconducting CNTs changes allowing them to sense biomarkers electrochemically (Choi et al, 2010). In general, FETs tend to be more sensitive than CRs due to their ability to tune the conductance of CNTs by controlling the gate voltage.…”

Section: Carbon Nanotubes (Cnts)mentioning

confidence: 99%

Detection of Cancer Biomarkers With Nanotechnology

Zhang

et al. 2013

American Journal of Biochemistry and Biotechnology

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Early detection of cancer biomarkers with high precision is critically important for cancer therapy. A variety of sensors based on different nanostructured materials have attracted intensive research interest due to their potential for highly sensitive and selective detection of cancer biomarkers. This review covers the use of a variety of nanostructured materials, including carbon nanotubes, silicon nanowires, gold nanoparticles and quantum dots, in the fabrication of sensors. Emphases are placed on how the detection systems work and what detection limits can be achieved. Some assays described in this review outperform established methods for cancer biomarker detection. It is highly promising that these sensors would soon move into commercial-scale production and find routine use in hospitals.

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“…Sensors based on nanoparticles or nanowires can detect proteins related to specific types of cancer cells in blood samples [31]. It allows early detection of cancer.…”

Section: Nanomedicine In Early Cancer Detectionmentioning

confidence: 99%

Nanomedicine - the Future of Cancer Treatment: A Review

Sebastian¹

2017

JCPCR

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Conventional cancer therapies are limited to surgery, radiation, and chemotherapy. Conventional treatments come with significant adverse effects. Modern cancer treatments focus on precise drug delivery to the cancer tissues and minimize adverse effects on healthy cells. Researchers have been working on an improved technique for delivering chemotherapeutic agents precisely at the molecular level in the tumor tissue. It has led to the use of nanotechnology in cancer treatment. Nanotechnology is the science and engineering of controlling matter, at the molecular scale, to create devices with novel chemical, physical and biological properties. Nanoscale objects are used themselves or as part of larger devices containing multiple nanoscale objects. Almost every field of Biosciences uses nanotechnology and all of which have an impact on biomedicine. It has the potential to change the current methods to diagnose and treat cancer. There has been real progress in translating nano-based cancer therapies and diagnostics into the clinic, and much more are in development. Nanoparticles are mainly used as nanocarriers to deliver the cytotoxic drugs to the tumor tissue. Use of nanoparticles is based on different concepts of pharmacology. Nanomedicine also is utilized to deliver multiple drugs at the cancer site at the same time for a better cytotoxic effect. CytImmune Sciences is a developing field of nanomedicine for targeted chemotherapy method. They selectively deliver the drug at the cancer site because of the increased permeability of the blood vessels at the tumor site. This article reviews various nanomedicine-based cancer therapeutics.

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Nanotechnology for Early Cancer Detection

Cited by 291 publications

References 146 publications

The potential legacy of cancer nanotechnology: cellular selection

The potential legacy of cancer nanotechnology: cellular selection

Detection of Cancer Biomarkers With Nanotechnology

Nanomedicine - the Future of Cancer Treatment: A Review

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