Nanotechnology in Cancer Drug Therapy: A Biocomputational Approach

Frieboes, Hermann B.; Sinek, John P.; Nalcioğlu, Orhan; Fruehauf, John P.; Cristini, Vittorio

doi:10.1007/978-0-387-25842-3_15

Cited by 20 publications

(11 citation statements)

References 67 publications

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“…To this end, mathematical modeling and computational simulation have been applied to help elucidate the effects of transport and diffusion of nanotherapeutics in the tumor microenvironment [1][2][3][4][5][6][7][8][9][10][11][12][13]. In particular, the dynamic interaction between generic nanoparticle vascular extravasation, uptake and distribution with heterogeneous tumor interstitial, vascular and lymphatic conditions was recently studied [7].…”

mentioning

confidence: 99%

An Interdisciplinary Computational/Experimental Approach to Evaluate Drug-Loaded Gold Nanoparticle Tumor Cytotoxicity

Curtis

England

et al. 2016

Nanomedicine (Lond.)

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Aim: Clinical translation of cancer nanotherapy has largely failed due to the infeasibility of optimizing the complex interaction of nano/drug/tumor/patient parameters. We develop an interdisciplinary approach modeling diffusive transport of drug-loaded gold nanoparticles in heterogeneously-vascularized tumors. Materials & methods: Evaluated lung cancer cytotoxicity to paclitaxel/cisplatin using novel two-layer (hexadecanethiol/phosphatidylcholine) and three-layer (with high-densitylipoprotein) nanoparticles. Computer simulations calibrated to in-vitro data simulated nanotherapy of heterogeneously-vascularized tumors. Results: Evaluation of freedrug cytotoxicity between monolayer/spheroid cultures demonstrates a substantial differential, with increased resistance conferred by diffusive transport. Nanoparticles had significantly higher efficacy than free-drug. Simulations of nanotherapy demonstrate 9.5% (cisplatin) and 41.3% (paclitaxel) tumor radius decrease. Conclusion: Interdisciplinary approach evaluating gold nanoparticle cytotoxicity and diffusive transport may provide insight into cancer nanotherapy.

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confidence: 99%

An Interdisciplinary Computational/Experimental Approach to Evaluate Drug-Loaded Gold Nanoparticle Tumor Cytotoxicity

Curtis

England

et al. 2016

Nanomedicine (Lond.)

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“…Chemotherapy is the systemic administration of anticancer drugs that travel throughout the body via the blood circulatory system. A signifi cant proportion of research investment is focused on improving the effi cacy of chemotherapy, which is often the only hope in treating a cancer patient (Frieboes et al 2006). While cancers are diverse, Hanahan and Weinberg (2000) have suggested that most, if not all, human cancers have acquired six basic capabilities: (i) self-suffi ciency in growth signals, (ii) insensitivity to growth-inhibitory signals, (iii) evasion of programmed cell death, (iv) limitless replicative potential, (v) sustained angiogenesis, and (vi) tissue invasion and metastasis.…”

Section: Introductionmentioning

confidence: 99%

Spatio-temporal tumour model for analysis and mechanism of action of intracellular drug accumulation

Mishra

Katiyar

2008

J Biosci

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We have developed a one-dimensional tumour simulator to describe the biodistribution of chemotherapeutic drugs to a tumoral lesion and the tumour cell's response to therapy. A three-compartment model is used for drug dynamics within the tumour. The first compartment represents the extracellular space in which cells move, the second corresponds to the intracellular fluid space (including cell membrane) which is in direct equilibrium with the extracellular space, and the third is a non-exchangeable compartment that represents sequestered drug which is trapped in the nucleus to damage the cellular DNA,directly triggering cell death. Analytical and numerical techniques (Finite Element Method) are used to describe the tumour's response to therapy and the effect of parameter variation on the drug concentration profiles in the three compartments.

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“…Mathematical models [8–9] and computer simulations [10–12] have been widely used to study the drug delivery mechanism. Previous models that have been proposed to study NP adhesion kinetics are mainly based on either the equilibrium approach [13–14] or kinetics approach[15].…”

Section: Introductionmentioning

confidence: 99%

Coupled particulate and continuum model for nanoparticle targeted delivery

Tan

Wang

Yang

et al. 2013

Computers & Structures

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Prediction of nanoparticle (NP) distribution in a vasculature involves transport phenomena at various scales and is crucial for the evaluation of NP delivery efficiency. A combined particulate and continuum model is developed to model NP transport and delivery processes. In the particulate model ligand-receptor binding kinetics is coupled with Brownian dynamics to study NP binding on a microscale. An analytical formula is derived to link molecular level binding parameters to particulate level adhesion and detachment rates. The obtained NP adhesion rates are then coupled with a convection-diffusion-reaction model to study NP transport and delivery at macroscale. The binding results of the continuum model agree well with those from the particulate model. The effects of shear rate, particle size and vascular geometry on NP adhesion are investigated. Attachment rates predicted by the analytical formula also agree reasonably well with the experimental data reported in literature. The developed coupled model that links ligand-receptor binding dynamics to NP adhesion rate along with macroscale transport and delivery processes may serve as a faster evaluation and prediction tool to determine NP distribution in complex vascular networks.

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Nanotechnology in Cancer Drug Therapy: A Biocomputational Approach

Cited by 20 publications

References 67 publications

An Interdisciplinary Computational/Experimental Approach to Evaluate Drug-Loaded Gold Nanoparticle Tumor Cytotoxicity

An Interdisciplinary Computational/Experimental Approach to Evaluate Drug-Loaded Gold Nanoparticle Tumor Cytotoxicity

Spatio-temporal tumour model for analysis and mechanism of action of intracellular drug accumulation

Coupled particulate and continuum model for nanoparticle targeted delivery

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