Nanotechnology in orthopedics: a clinically oriented review

Smith, Walter R.; Hudson, Parke; Ponce, Brent A.; Manoharan, Sakthivel Rajan Rajaram

doi:10.1186/s12891-018-1990-1

Cited by 59 publications

(36 citation statements)

References 85 publications

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“…In certain patient groups, disability rates remain unacceptably high even in spite of timely and proper diagnostics and treatment [ 2 , 3 , 4 , 5 ]. Therefore, harnessing of bone regeneration by using xenogeneic bone implants instead of ceramic or metal alternatives is still an unmet clinical need [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Native Bovine Hydroxyapatite Powder, Demineralised Bone Matrix Powder, and Purified Bone Collagen Membranes Are Efficient in Repair of Critical-Sized Rat Calvarial Defects

et al. 2020

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Here we evaluated the efficacy of bone repair using various native bovine biomaterials (refined hydroxyapatite (HA), demineralised bone matrix (DBM), and purified bone collagen (COLL)) as compared with commercially available bone mineral and bone autografts. We employed a conventional critical-sized (8 mm diameter) rat calvarial defect model (6-month-old male Sprague–Dawley rats, n = 72 in total). The artificial defect was repaired using HA, DBM, COLL, commercially available bone mineral powder, bone calvarial autograft, or remained unfilled (n = 12 animals per group). Rats were euthanised 4 or 12 weeks postimplantation (n = 6 per time point) with the subsequent examination to assess the extent, volume, area, and mineral density of the repaired tissue by means of microcomputed tomography and hematoxylin and eosin staining. Bovine HA and DBM powder exhibited excellent repair capability similar to the autografts and commercially available bone mineral powder while COLL showed higher bone repair rate. We suggest that HA and DBM powder obtained from bovine bone tissue can be equally applied for the repair of bone defects and demonstrate sufficient potential to be implemented into clinical studies.

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Section: Introductionmentioning

confidence: 99%

Native Bovine Hydroxyapatite Powder, Demineralised Bone Matrix Powder, and Purified Bone Collagen Membranes Are Efficient in Repair of Critical-Sized Rat Calvarial Defects

et al. 2020

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“…For instance, the repair of large bone defects resulting from trauma requires a mechanically competent scaffold (Masquelet et al, 2000). Arthroplasty, on the other hand, calls for strategies that improve implant lifespan, as the longevity of conventional materials remains a major limitation in this setting (Smith et al, 2018). For this application, the key to success lies in improving the osseointegration of existing implants through surface modifications (Serra et al, 2013;Puertolas and Kurtz, 2014).…”

Section: Discussionmentioning

confidence: 99%

Nanostructured Biomaterials for Bone Regeneration

Lyons

Plantz

Hsu

et al. 2020

Front. Bioeng. Biotechnol.

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This review article addresses the various aspects of nano-biomaterials used in or being pursued for the purpose of promoting bone regeneration. In the last decade, significant growth in the fields of polymer sciences, nanotechnology, and biotechnology has resulted in the development of new nano-biomaterials. These are extensively explored as drug delivery carriers and as implantable devices. At the interface of nanomaterials and biological systems, the organic and synthetic worlds have merged over the past two decades, forming a new scientific field incorporating nano-material design for biological applications. For this field to evolve, there is a need to understand the dynamic forces and molecular components that shape these interactions and influence function, while also considering safety. While there is still much to learn about the bio-physicochemical interactions at the interface, we are at a point where pockets of accumulated knowledge can provide a conceptual framework to guide further exploration and inform future product development. This review is intended as a resource for academics, scientists, and physicians working in the field of orthopedics and bone repair.

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“…Травмы и иные приобретенные, а также врожденные патологии опорно-двигательного аппарата до сих пор представляют собой распростран нную причину инвалидизации населения работоспособного возраста даже при успешном исходе оперативного вмешательства [2][3][4][5]. С целью решения этой проблемы идет активный поиск альтернативных решений для механического замещения костных дефектов [6][7][8].…”

Section: English введениеunclassified

Xenogeneic bone mineral is efficient for the repair of critical-sized rat calvarial defects

Веремеев

Болгарин²,

Нестеренко

et al. 2021

Fundamentalʹnaâ i kliničeskaâ medicina

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Aim. To evaluate the efficiency of bone repair on a critical-sized rat calvarial defect model using our original xenogeneic bone mineral, widely established Geistlich Bio-Oss®, and autologous bone graft.Materials and Methods. We created a critical-sized calvarial defect in Sprague-Dawley rats (n = 48) and then divided them into 4 groups (unfilled defect, autologous bone graft, Geistlich BioOss® and our original xenogeneic bone mineral, 12 rats per group). Rats were sacrificed upon 4 and 12 months (6 rats per time point) with the following excision of the implant and adjacent tissues. 3D structure, extent of mineralisation, and bone volume were measured by means of microcomputed tomography. Microanatomy of the explants and adjacent tissue was investigated by haematoxylin and eosin staining.Results. The highest and the lowest bone volume was expectedly detected when the defect was filled with the autologous bone graft or remained unfilled, respectively. Replacement of the defect by the original bone mineral entailed better regeneration as compared to Geistlich Bio-Oss. Bone mineral density, bone thickness and the extent of mineralisation did not differ significantly between the experimental groups and were close to the positive control values, indicating efficient bone repair.Conclusions. Original xenogeneic bone mineral promotes induction of bone regeneration as compared to Geistlich Bio-Oss®, a commercially available bone mineral widely used in the clinical practice.

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Nanotechnology in orthopedics: a clinically oriented review

Cited by 59 publications

References 85 publications

Native Bovine Hydroxyapatite Powder, Demineralised Bone Matrix Powder, and Purified Bone Collagen Membranes Are Efficient in Repair of Critical-Sized Rat Calvarial Defects

Native Bovine Hydroxyapatite Powder, Demineralised Bone Matrix Powder, and Purified Bone Collagen Membranes Are Efficient in Repair of Critical-Sized Rat Calvarial Defects

Nanostructured Biomaterials for Bone Regeneration

Xenogeneic bone mineral is efficient for the repair of critical-sized rat calvarial defects

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