Nanotechnology shows promise for next-generation vaccines in the fight against COVID-19

Mufamadi, Maluta Steven

doi:10.1557/mrs.2020.307

Cited by 10 publications

(6 citation statements)

References 7 publications

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“…Nanocarriers protect and shield the DNA vaccine from degradation by DNases and other enzymes (Cai et al 2018 ). Liposomes or lipid nanoparticles, polymers, chitosan-based, functionalized silica nanoparticles can be employed in DNA vaccine delivery systems, as revealed in various animal experiments (Mucker et al 2020 ; Tatlow et al 2020 ; Theobald 2020 ; Zhao et al 2013 ; Zhao et al 2021 ). The alternative ways to increase the efficiency of DNA vaccine delivery could be the addition of adjuvants and applying a transcutaneous microneedle delivery system.…”

Section: Nano-based Vaccines In the Development Of A Potential Covid-19 Vaccinementioning

confidence: 99%

COVID-19 phase 4 vaccine candidates, effectiveness on SARS-CoV-2 variants, neutralizing antibody, rare side effects, traditional and nano-based vaccine platforms: a review

Simnani

Singh

Kaur³

2021

3 Biotech

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The COVID-19 pandemic has endangered world health and the economy. As the number of cases is increasing, different companies have started developing potential vaccines using both traditional and nano-based platforms to overcome the pandemic. Several countries have approved a few vaccine candidates for emergency use authorization (EUA), showing significant effectiveness and inducing a robust immune response. Oxford-AstraZeneca, Pfizer-BioNTech’s BNT162, Moderna’s mRNA-1273, Sinovac’s CoronaVac, Johnson & Johnson, Sputnik-V, and Sinopharm’s vaccine candidates are leading the race. However, the SARS-CoV-2 is constantly mutating, making the vaccines less effective, possibly by escaping immune response for some variants. Besides, some EUA vaccines have been reported to induce rare side effects such as blood clots, cardiac injury, anaphylaxis, and some neurological effects. Although the COVID-19 vaccine candidates promise to overcome the pandemic, a more significant and clear understanding is needed. In this review, we brief about the clinical trial of some leading candidates, their effectiveness, and their neutralizing effect on SARS-CoV-2 variants. Further, we have discussed the rare side effects, different traditional and nano-based platforms to understand the scope of future development.

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Section: Nano-based Vaccines In the Development Of A Potential Covid-19 Vaccinementioning

confidence: 99%

COVID-19 phase 4 vaccine candidates, effectiveness on SARS-CoV-2 variants, neutralizing antibody, rare side effects, traditional and nano-based vaccine platforms: a review

Simnani

Singh

Kaur³

2021

3 Biotech

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“…Human minds are set to be nanorobotically connected to the cloud and to computers within the next few decades; individuals are set to be injected with “knowledge” and “facts”; digitised minds that are transferred to the cloud systems would be stored everywhere to be easily accessed; nanobots are helping to scan and upload the human minds; mind transfer would involve separating the consciousness of a person and transferring it to a new medium such as those mediums which are being developed by private companies in Silicon Valley and by the European Union; information about a person is copied and then uploaded to a synthetic substrate such as a robot or a digital computer; thus, humans are being taught that they would evade death by transferring their consciousness or minds to the cloud system and to technological substrates or by uploading their minds into cyberspace or silicone bodies (Martins et al, 2019 ; Martin, 2019 ; Laakasuo et al, 2018 ; Osinski, 2021 ; Bamford & Danaher, 2017 ; Bett, 2022 ; Bell, 2018 ; Edache, 2021 ). While it is noted that scanning the human brains is done through nanobots or nanorobots, the same nanobots or nanorobots and nanotechnologies, more generally, are already being used in producing COVID-19 vaccines that are being injected into human bodies and many people are already suffering memory loss following COVID-19 (vaccinations) (Feng et al, 2022 ; Mufamadi, 2020 ; Singh et al, 2021 ; Chaurasia et al, 2022 ; Davies, 2022 ; van Beusekom, 2022 ; Reuters, 2022 ; Soraas et al, 2021 ; Zlotnik et al, 2022 ; Hellewell, 2022 ; Strain et al, 2022 ). The transhumanist idea in all these processes, as Harari ( 2016 ) notes, is to usher in Dataism which connects everything including biological and nonbiological things.…”

Section: Dispossessed Of Their African Voices and Mindsmentioning

confidence: 99%

Kukumirwa Semombe Dzamavhu: When Voices Begin to Erupt from Bottoms, African Anthropology Becomes Colonial

Nhemachena

2022

J Afr Am St

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On a continent where Africans suffered crises of dispossession, it is inaccurate to describe such crises as crises in representations. Drawing on Shona (people of Zimbabwe) proverb kukumirwa semombe dzamavhu (being mooed for as if one is a cow made of clay), this paper argues that colonial anthropology did not only generate crises in representations but anthropologists took it upon themselves to ‘moo’ for Africans. Similarly, emergent futures herald human minds being nanotechnologically scanned and transferred to clouds and into technological substrates. In this sense, crises of dispossession will worsen when humans are dispossessed of their minds, so scanned and transferred from biological brains to clouds and into technological substrates. Contributing insights to the anthropology of science and technology studies, this paper argues that with minds transferred from the biological brains, in the guise of defying mortality, Africans will be dispossessed of their voices and their minds.

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“…Cationic polymers and LNPs are employed to carry plasmid DNA into the nucleus of host cells in lung tissues, where it promotes a particular immune response. In human testing [55], NVX-CoV2373 is a recombinant protein nanotech vaccine. In a mouse model of acute lung damage, hAFS cells were tagged with dual polymer-coated nanoparticles.…”

Section: Regeneration Of Lung Tissues Using Biopolymeric Nanoparticles For Covid-19 Patientsmentioning

confidence: 99%

The Potential Contribution of Biopolymeric Particles in Lung Tissue Regeneration of COVID-19 Patients

et al. 2021

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The lung is a vital organ that houses the alveoli, which is where gas exchange takes place. The COVID-19 illness attacks lung cells directly, creating significant inflammation and resulting in their inability to function. To return to the nature of their job, it may be essential to rejuvenate the afflicted lung cells. This is difficult because lung cells need a long time to rebuild and resume their function. Biopolymeric particles are the most effective means to transfer developing treatments to airway epithelial cells and then regenerate infected lung cells, which is one of the most significant symptoms connected with COVID-19. Delivering biocompatible and degradable natural biological materials, chemotherapeutic drugs, vaccines, proteins, antibodies, nucleic acids, and diagnostic agents are all examples of these molecules‘ usage. Furthermore, they are created by using several structural components, which allows them to effectively connect with these cells. We highlight their most recent uses in lung tissue regeneration in this review. These particles are classified into three groups: biopolymeric nanoparticles, biopolymeric stem cell materials, and biopolymeric scaffolds. The techniques and processes for regenerating lung tissue will be thoroughly explored.

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Nanotechnology shows promise for next-generation vaccines in the fight against COVID-19

Cited by 10 publications

References 7 publications

COVID-19 phase 4 vaccine candidates, effectiveness on SARS-CoV-2 variants, neutralizing antibody, rare side effects, traditional and nano-based vaccine platforms: a review

COVID-19 phase 4 vaccine candidates, effectiveness on SARS-CoV-2 variants, neutralizing antibody, rare side effects, traditional and nano-based vaccine platforms: a review

Kukumirwa Semombe Dzamavhu: When Voices Begin to Erupt from Bottoms, African Anthropology Becomes Colonial

The Potential Contribution of Biopolymeric Particles in Lung Tissue Regeneration of COVID-19 Patients

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