Nanotherapeutic Potential of Antibacterial Folic Acid-Functionalized Nanoceria for Wound-Healing Applications

Sarkar, Kunal; Dutta, Kaushik; Chatterjee, Arindam; Sarkar, Jit; Das, Dipankar; Prasad, Arbind; Chattopadhyay, Dipankar; Acharya, Krishnendu; Das, Madhusudan; Verma, Suresh K.; De, S. S.

doi:10.2217/nnm-2022-0233

Cited by 14 publications

(4 citation statements)

References 39 publications

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“…Intracellular ROS generation was measured by DCFDA staining according to [ 44 ]. Cells were divided into five groups and treated according to the doses as previously mentioned in Sect.…”

Section: Methodsmentioning

confidence: 99%

Hyaluronic acid-graphene oxide quantum dots nanoconjugate as dual purpose drug delivery and therapeutic agent in meta-inflammation

et al. 2023

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Type 2 diabetes mellitus (T2DM) predominantly considered a metabolic disease is now being considered an inflammatory disease as well due to the involvement of meta-inflammation. Obesity-induced adipose tissue inflammation (ATI) is one of the earliest phenomena in the case of meta-inflammation, leading to the advent of insulin resistance (IR) and T2DM. The key events of ATI are orchestrated by macrophages, which aggravate the inflammatory state in the tissue upon activation, ultimately leading to systemic chronic low-grade inflammation and Non-Alcoholic Steatohepatitis (NASH) through the involvement of proinflammatory cytokines. The CD44 receptor on macrophages is overexpressed in ATI, NASH, and IR. Therefore, we developed a CD44 targeted Hyaluronic Acid functionalized Graphene Oxide Quantum Dots (GOQD-HA) nanocomposite for tissue-specific delivery of metformin. Metformin-loaded GOQD-HA (GOQD-HA-Met) successfully downregulated the expression of proinflammatory cytokines and restored antioxidant status at lower doses than free metformin in both palmitic acid-induced RAW264.7 cells and diet induced obese mice. Our study revealed that the GOQD-HA nanocarrier enhanced the efficacy of Metformin primarily by acting as a therapeutic agent apart from being a drug delivery platform. The therapeutic properties of GOQD-HA stem from both HA and GOQD having anti-inflammatory and antioxidant properties respectively. This study unravels the function of GOQD-HA as a targeted drug delivery option for metformin in meta-inflammation where the nanocarrier itself acts as a therapeutic agent. Graphical Abstract

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“…Intracellular ROS generation was measured by DCFDA staining according to [ 44 ]. Cells were divided into five groups and treated according to the doses as previously mentioned in Sect.…”

Section: Methodsmentioning

confidence: 99%

Hyaluronic acid-graphene oxide quantum dots nanoconjugate as dual purpose drug delivery and therapeutic agent in meta-inflammation

et al. 2023

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“…They found that the bactericidal and biofilm inhibition effects of the folate-decorated liposomes incorporating vancomycin was higher compared to direct vancomycin application, suggesting superior MRSA targeting and delivery of the drug [90]. The targeting potential of folate functionalization was also confirmed by the superior targeting and antibacterial enhancement of the efficacy of folate-functionalized cerium NPs [91]. This has been widely exploited in PDT studies.…”

Section: Antibacterial Photodynamic Therapy Folate Targetingmentioning

confidence: 97%

Important Advances in Antibacterial Nanoparticle-Mediated Photodynamic Therapy

Phinda Songca

2024

Recent Advances in Bacterial Biofilm Studies - Formation, Regulation, and Eradication in Human Infections

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Earlier applications of photodynamic therapy (PDT) were accomplished by direct or intravenous injection of the photosensitizer, followed by preferential accumulation in cancerous tissues after systemic circulation. Nowadays, nanoparticles are used as carriers and delivery systems, which also facilitate combinations of PDT with other non-invasive technologies. PDT has expanded to disease types other than cancers. Nanoparticle-mediated target specific PDT can reduce the emergence of resistance, and has introduced chemotherapy combinations with PDT, and potential repurposing of chemotherapy drugs that are being used less because of resistance. The novel discoveries of inorganic and organic dye nanoconjugate photosensitizers discussed in this chapter have enhancement PDT efficacy. This review describes the type I and II mechanisms of PDT, some of the first- and second-generation photosensitizers in the market, and the roles played by nanomaterials across the PDT clinical translation value chain. It discusses nanoparticles as delivery systems for photosensitizers, smart stimulus-responsive, and disease-targeting nanoparticles, focusing on folate, glycan-based, pH, and external stimulus-responsive targeting. Well-known in anticancer applications, folate targeting is now debuting in antibacterial applications. Other targeting technologies are discussed. Nanoparticles applications as agents for combining PDT with other therapies are discussed. The World Health Organization has identified PDT as a promising new technology.

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“…ZnO NPs were seen to reduce the expression of IL-1β, IL-6, and TNF-α in a dose-dependent manner in RAW 264.7 cells. ROS causes inflammation by initiating lipid peroxidation in the phospholipid membrane [169,170]. Controlling ROS formation, therefore, helps ZnO NP anti-inflammatory activity ZnO NPs reduce the expression of pro-inflammatory genes and proteins, allowing for the treatment of inflammatory illnesses.…”

Section: Doxorubicin Hepg2 Cellsmentioning

confidence: 99%

Emerging Trends in the Application of Green Synthesized Biocompatible ZnO Nanoparticles for Translational Paradigm in Cancer Therapy

Naser,

Ghosh,

Simnani

et al. 2023

JNT

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Zinc oxide nanomaterials have been the cynosure of this decade because of their immense potential in different biomedical applications. It includes their usage in the prognosis and treatment of different infectious and cellular diseases, owing to their peculiar physiochemical properties such as variable shape, size, and surface charge etc. Increasing demand and usage of the ZnO nanomaterials raise concerns about their cellular and molecular toxicity and their biocompatibility with human cells. This review comprehensively details their physiochemical properties for usage in biomedical applications. Furthermore, the toxicological concerns of ZnO nanomaterials with different types of cellular systems have been reviewed. Moreover, the biomedical and biocompatible efficacy of ZnO nanomaterials for cancer specific pathways has been discussed. This review offers insights into the current scenario of ZnO nanomaterials usage and signifies their potential future extension usage on different types of biomedical and environmental applications.

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Nanotherapeutic Potential of Antibacterial Folic Acid-Functionalized Nanoceria for Wound-Healing Applications

Cited by 14 publications

References 39 publications

Hyaluronic acid-graphene oxide quantum dots nanoconjugate as dual purpose drug delivery and therapeutic agent in meta-inflammation

Hyaluronic acid-graphene oxide quantum dots nanoconjugate as dual purpose drug delivery and therapeutic agent in meta-inflammation

Important Advances in Antibacterial Nanoparticle-Mediated Photodynamic Therapy

Emerging Trends in the Application of Green Synthesized Biocompatible ZnO Nanoparticles for Translational Paradigm in Cancer Therapy

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