Nanotubes for tissue engineering

Mikael, Paiyz E.; Wallace, Jason A.; Nukavarapu, Syam P.

doi:10.1533/9780857096449.3.460

Cited by 2 publications

(1 citation statement)

References 91 publications

(92 reference statements)

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“…Depending on the interacting biomolecules, they are functionalized by oxidizing them with strong acids and conjugating them with amino acids, or by coating them with amphiphilic molecules (like PEG, Poly Ethylene Glycol). 21 Today, their applications are being vigorously researched in a variety of biomedical engineering disciplines (imaging diagnostics, tissue engineering, drug delivery, and biosensors). 22 CNTs were introduced into the field of biomaterials due to their excellent mechanical, thermal, and electrical properties, as well as their durability.…”

Section: Polymer Based Fillersmentioning

confidence: 99%

Ceramic and Polymeric Composite Materials used in Reinforcing UHMWPE for Improved Mechanical and Tribological Properties in Orthopedic Applications

Balivada,

Nayak,

Johnson

et al. 2022

IJHTI

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UHMWPE is a popular choice of biomaterial for joint replacements, particularly in hip, knee, and shoulder replacement procedures, notably as sliding material in between the load bearing surfaces due to its superior biocompatibility, tensile yield, impact strength, and high crystallinity. Even though it has good mechanical qualities, it has a relatively low wear resistance, which causes wear particles to shred and trigger immunological reactions and possibly osteolysis. This also has an impact on the implant’s lifetime. The wear issue can be solved using a variety of approaches, including thermal therapy and antioxidant infusion. The mechanical qualities suffer as a result of these methods’ efficacy in addressing tribological problems. One such way of reducing wear and oxidation rates while preserving mechanical characteristics is reinforcing the conventional UHMWPE with various composite materials. In this review the tensile and tribological properties of such ceramic and polymeric materials like zirconia, hydroxyapatite, carbon nanotube and graphene are evaluated. This review will investigate several ceramic and polymer-based fillers as an alternative to currently used methods such as improved radiation cross-linking and antioxidant treatment. CNT reinforced UHMWPE is still in the testing stage and is not yet on the market due to biocompatibility concerns. However, when compared to their competitors, their tribological properties are adequate but not exceptional. The best tensile properties are found in hydroxyapatite reinforced UHMWPE (but only at high concentrations such as 30wt%), followed by CNT. They do not have biocompatibility issues like CNT because of their structural similarity to natural bone. They also outperform CNT and ATZ composites in terms of tribological properties. As a result, they are best suited for reinforcement (with UHMWPE).

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Section: Polymer Based Fillersmentioning

confidence: 99%

Ceramic and Polymeric Composite Materials used in Reinforcing UHMWPE for Improved Mechanical and Tribological Properties in Orthopedic Applications

Balivada,

Nayak,

Johnson

et al. 2022

IJHTI

View full text Add to dashboard Cite

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Controlled Release of Antimicrobial Small Molecules

Zilberman

Koren

Guez

et al. 2019

Antimicrobial Materials for Biomedical Applications

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Controlled release of antimicrobial small molecules is designed to be used for prevention and/or treatment infections associated with a large variety of wound occurrences, ranging from traumatic skin tears and burns to chronic ulcers and complications following surgery and device implantations. The main goal in treating infections is to decrease the bacterial load in the wound site to a level that enables wound healing processes to take place. Local delivery of antibiotics by either topical administration or a delivery device should enable the maintenance of a high local antibiotic concentration for an extended duration of release without exceeding systemic toxicity. The antimicrobial delivery system should be made of biocompatible and biodegradable materials, able to carry a sufficient drug concentration, and release the drug at the appropriate rate for an optimal treatment of the infected tissue. In recent years, various platforms have been developed in order to carry different types of antimicrobial small molecules and treat numerous organs and infections. This chapter describes the main types of these systems. These are based on nanoparticles, fibers, dendrimers, liposomes, nanotubes, and films. Emphasis is placed on processing techniques, nanostructure/microstructure, drug release profiles, biocompatibility and other relevant aspects necessary for advancing the therapeutic field of antimicrobial delivery devices. The final part of this chapter is dedicated to novel concepts in antibiotic-loaded bioresorbable films that we have developed. It focuses on structuring effects of dense and porous films, as well as novel soy protein based systems.

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Nanotubes for tissue engineering

Cited by 2 publications

References 91 publications

Ceramic and Polymeric Composite Materials used in Reinforcing UHMWPE for Improved Mechanical and Tribological Properties in Orthopedic Applications

Ceramic and Polymeric Composite Materials used in Reinforcing UHMWPE for Improved Mechanical and Tribological Properties in Orthopedic Applications

Controlled Release of Antimicrobial Small Molecules

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