Nanovaccines formulation and applications-a review

Yadav, Hemant Kumar; Dibi, Manar; Mohammad, Alyazya; Srouji, Abrar E.

doi:10.1016/j.jddst.2018.01.015

Cited by 30 publications

(20 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While some vaccines mitigate this risk using inactivated pathogens instead, these induce a weaker immune response. Nanovaccines, due to the aforementioned properties, can overcome these issues and work across a broad-spectrum of immunity [48] .…”

Section: Nanovaccinesmentioning

confidence: 99%

See 1 more Smart Citation

Nanoparticles as delivery vehicles for antiviral therapeutic drugs

Maus

Strait

Zhu

2021

Engineered Regeneration

View full text Add to dashboard Cite

With the ongoing COVID-19 pandemic still escalating, many researchers are turning to nanotechnology as a method of treatment not only for this pandemic, but in preparation for the pandemics of the future. Given both a wide variety of biomaterials at their disposal and the recent rise of nanotechnology, scientists now have the means to release and distribute therapeutic drugs in a variety of ways. Such a variety permits medical professionals the ability to choose biomaterials and methods that would provide the best release and treatment methodologies for the viral ailment they are attempting to remedy. This integrative review discusses context of previous pandemics, viral pathogenesis, issues associated with the current state of antiviral delivery systems, numerous biomaterials used for this purpose, and further information regarding the ongoing global COVID-19 pandemic.

show abstract

Section: Nanovaccinesmentioning

confidence: 99%

“…They are surface modified to carry the vaccines antigens or express the epitomes to target antigen-presenting cells. In terms of metallic systems, sulfide or thiolate gold chemistry have shown promising results regarding successful presentation of antigenic epitopes [48] .…”

Section: Nanovaccinesmentioning

confidence: 99%

Nanoparticles as delivery vehicles for antiviral therapeutic drugs

Maus

Strait

Zhu

2021

Engineered Regeneration

View full text Add to dashboard Cite

show abstract

“…In infectious diseases, dendrimers can support the development of vaccines by acting as antigens carrier, providing stability, safety, and a sustained release. In addition, they can serve as adjuvants or can promote the uptake of the antigen by the antigen-presenting cells, thus enhancing its recognition and improving the effectiveness of the vaccine [ 45 ].…”

Section: Dendrimers: Synthesis Uses and Challenges To Face In Bimentioning

confidence: 99%

Dendrimers and Dendritic Materials: From Laboratory to Medical Practice in Infectious Diseases

et al. 2020

View full text Add to dashboard Cite

Infectious diseases are one of the main global public health risks, predominantly caused by viruses, bacteria, fungi, and parasites. The control of infections is founded on three main pillars: prevention, treatment, and diagnosis. However, the appearance of microbial resistance has challenged traditional strategies and demands new approaches. Dendrimers are a type of polymeric nanoparticles whose nanometric size, multivalency, biocompatibility, and structural perfection offer boundless possibilities in multiple biomedical applications. This review provides the reader a general overview about the uses of dendrimers and dendritic materials in the treatment, prevention, and diagnosis of highly prevalent infectious diseases, and their advantages compared to traditional approaches. Examples of dendrimers as antimicrobial agents per se, as nanocarriers of antimicrobial drugs, as well as their uses in gene transfection, in vaccines or as contrast agents in imaging assays are presented. Despite the need to address some challenges in order to be used in the clinic, dendritic materials appear as an innovative tool with a brilliant future ahead in the clinical management of infectious diseases and many other health issues.

show abstract

“…Despite recent progress, improvements are still required due to concerns about weak immunogenicity, intrinsic instability, and toxicity in vivo, besides the need for multiple administrations. To overcome these limitations, nanotechnology platforms have been recently introduced in vaccine development for the prevention and treatment of infectious diseases [134]. Plasmid DNA (pDNA) vaccines have been shown to act against a wide range of diseases but have low efficacy and require multiple administrations due to their poor cell uptake and rapid degradation by the nucleases [135].…”

Section: Biocompatible Nanocarrier-loaded Poloxamer 407 Hydrogelsmentioning

confidence: 99%

Drug-Loaded Biocompatible Nanocarriers Embedded in Poloxamer 407 Hydrogels as Therapeutic Formulations

et al. 2018

View full text Add to dashboard Cite

Hydrogels are three-dimensional networks of hydrophilic polymers able to absorb and retain a considerable amount of water or biological fluid while maintaining their structure. Among these, thermo-sensitive hydrogels, characterized by a temperature-dependent sol–gel transition, have been massively used as drug delivery systems for the controlled release of various bioactives. Poloxamer 407 (P407) is an ABA-type triblock copolymer with a center block of hydrophobic polypropylene oxide (PPO) between two hydrophilic polyethyleneoxide (PEO) lateral chains. Due to its unique thermo-reversible gelation properties, P407 has been widely investigated as a temperature-responsive material. The gelation phenomenon of P407 aqueous solutions is reversible and characterized by a sol–gel transition temperature. The nanoencapsulation of drugs within biocompatible delivery systems dispersed in P407 hydrogels is a strategy used to increase the local residence time of various bioactives at the injection site. In this mini-review, the state of the art of the most important mixed systems made up of colloidal carriers localized within a P407 hydrogel will be provided in order to illustrate the possibility of obtaining a controlled release of the entrapped drugs and an increase in their therapeutic efficacy as a function of the biomaterial used.

show abstract

Nanovaccines formulation and applications-a review

Cited by 30 publications

References 45 publications

Nanoparticles as delivery vehicles for antiviral therapeutic drugs

Nanoparticles as delivery vehicles for antiviral therapeutic drugs

Dendrimers and Dendritic Materials: From Laboratory to Medical Practice in Infectious Diseases

Drug-Loaded Biocompatible Nanocarriers Embedded in Poloxamer 407 Hydrogels as Therapeutic Formulations

Contact Info

Product

Resources

About