2015
DOI: 10.1007/s11743-015-1746-y
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Nanovesicles Based on Mixtures of a Biantennary Glycolipid with Ionic Co‐Surfactants

Abstract: A biantennary surfactant based on a synthetic C16‐maltoside was chosen to prepare vesicles for a potential vesicular drug delivery system. The synthesis comprised of three stages: Initial synthesis of β‐d‐maltose octaacetate was followed by glycosidation of 2‐hexyl‐decanol and final glycolipid deacetylation. Both α‐ and β‐anomers were prepared and their anomeric purity was evaluated by 1H NMR. Owing to the low water solubility of the glycolipid, addition of ionic co‐surfactants was believed to promote the surf… Show more

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Cited by 7 publications
(1 citation statement)
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“…This leads to a further novel approach as researchers can broaden their horizon in selecting the lipid components as the starting materials for more natural and greener products, such as cardanol, sugar-based surfactants, glycolipids, and biosurfactants. [302][303][304][305][306] However, the Cpp of the lipid surfactants must be acknowledged since the morphology prediction would determine the success of preparing any lipid-based nanoparticles. For example, non-ionic lipid surfactants that have (1/2 < Cpp < 1) would form vesicles (niosomes) in an aqueous medium but other types of non-ionic lipid surfactants with (1/3 < Cpp < 1/2) would form cylindrical micelles (nanoemulsions), [171][172][173] as discussed in Section 5.0.…”
Section: Future Prospects Of Lipid-based Nanoparticles In Pharmaceuti...mentioning
confidence: 99%
“…This leads to a further novel approach as researchers can broaden their horizon in selecting the lipid components as the starting materials for more natural and greener products, such as cardanol, sugar-based surfactants, glycolipids, and biosurfactants. [302][303][304][305][306] However, the Cpp of the lipid surfactants must be acknowledged since the morphology prediction would determine the success of preparing any lipid-based nanoparticles. For example, non-ionic lipid surfactants that have (1/2 < Cpp < 1) would form vesicles (niosomes) in an aqueous medium but other types of non-ionic lipid surfactants with (1/3 < Cpp < 1/2) would form cylindrical micelles (nanoemulsions), [171][172][173] as discussed in Section 5.0.…”
Section: Future Prospects Of Lipid-based Nanoparticles In Pharmaceuti...mentioning
confidence: 99%