2011
DOI: 10.1002/wnan.172
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Nanowired drug delivery for neuroprotection in central nervous system injuries: modulation by environmental temperature, intoxication of nanoparticles, and comorbidity factors

Abstract: Recent developments in nanomedicine resulted in targeted drug delivery of active compounds into the central nervous system (CNS) either through encapsulated material or attached to nanowires. Nanodrug delivery by any means is supposed to enhance neuroprotection due to rapid accumulation of drugs within the target area and a slow metabolism of the compound. These two factors enhance neuroprotection than the conventions drug delivery. However, this is still uncertain whether nanodrug delivery could alter the pha… Show more

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Cited by 60 publications
(15 citation statements)
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References 108 publications
(365 reference statements)
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“…It is possible that smaller NPs have a higher mobility and penetrability across cell membranes in vivo explaining, at least in part, their greater damaging capability in SD [66,67]. Alternatively, since SD has already opened the BBB due to stress, smaller-sized NPs could penetrate deeper into the brain, leading to more stress and cellular damage [46][47][48]65]. Damage to circulating platelets by smaller-sized NPs could induce additional release of 5-HT that may reach brain tissues due to breakdown in the BBB, leading to higher brain 5-HT levels in NP-intoxicated SD groups [68][69][70].…”
Section: Discussionmentioning
confidence: 99%
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“…It is possible that smaller NPs have a higher mobility and penetrability across cell membranes in vivo explaining, at least in part, their greater damaging capability in SD [66,67]. Alternatively, since SD has already opened the BBB due to stress, smaller-sized NPs could penetrate deeper into the brain, leading to more stress and cellular damage [46][47][48]65]. Damage to circulating platelets by smaller-sized NPs could induce additional release of 5-HT that may reach brain tissues due to breakdown in the BBB, leading to higher brain 5-HT levels in NP-intoxicated SD groups [68][69][70].…”
Section: Discussionmentioning
confidence: 99%
“…Damage to circulating platelets by smaller-sized NPs could induce additional release of 5-HT that may reach brain tissues due to breakdown in the BBB, leading to higher brain 5-HT levels in NP-intoxicated SD groups [68][69][70]. That Ag NPs of same size as Cu NPs produce greater damage suggests that the inherent properties of NPs are also important in bringing about oxidative stress or cellular damage [46][47][48].…”
Section: Discussionmentioning
confidence: 99%
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“…105,107 In particular, a recent study 69 demonstrates that the administration of polyamidoamine (PAMAM) dendrimers could be taken up in the brain of injured animals and selectively localize in the injured neurons and microglia in the brain. Besides, these dendrimers were also able to deliver two clinically approved drugs, N-acetyl cysteine (attenuating neuroinflammation) and valproic acid (attenuating excitotoxicity), building on positive outcomes in a rabbit model of perinatal brain injury.…”
Section: Traumatic Brain Injurymentioning
confidence: 99%
“…19,20 Only a few novel nanodelivery systems, such as solid lipid nanoparticles, nano-phytosome, and nanoemulsion, have shown good efficacy in the delivery of phytobioactive compounds. Very recently controlled delivery of drugs was studied using nanowire systems, [21][22][23] and their efficacy in delivery of drugs to the diabetic model is still limited. The current review presents the potential use of various nanoscale drug delivery systems for phyto-based bioactive compounds to treat T2DM and its associated complications.…”
Section: Introductionmentioning
confidence: 99%