Nanozymatic detection of thiocyanate through accelerating the growth of ultra-small gold nanoparticles/graphene quantum dots hybrids

Ahmed, Syed Rahin; Sherazee, Masoomeh; Srinivasan, Seshasai; Rajabzadeh, Amin Reza

doi:10.1016/j.foodchem.2022.132152

Cited by 19 publications

(6 citation statements)

References 41 publications

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“…The research and discovery of nanomaterials with enzyme-like activity (nanozymes) have been receiving a lot of focus among researchers because of their higher stability and greater cost efficiency. − The innovation of the peroxidase-like activity of iron oxide nanoparticles (Fe 3 O 4 NPs) has inspired many researchers to develop nanomaterials-based artificial enzymes . To date, a large number of nanomaterials have been identified as nanozymes, for example, palladium nanoparticles (Pd NPs), gold nanoparticles (Au NPs), platinum nanoparticles (Pt NPs), graphene, carbon nanotubes and many more nanomaterials .…”

Section: Introductionmentioning

confidence: 99%

“…Generally, smaller particles showed better nanozymatic activity because of the surface-to-volume ratio. Inspired by the size effect, some researchers have reported the nanozymatic activity of quantum dots (smaller in size than nanomaterials), for example, carbon dots, Fe 3 O 4 QDs, and graphdiyne QDs. ,, Also, the importance of the hydroxyl radical (•OH) scavenging ligands on the surface of nanozymes has been described in different articles. − Hence, the design of QDs with •OH radical attachment on the surface might be attractive to scientists across many research fields. Moreover, it is well-established that the intensity and time of color development in the nanozymatic reaction strongly influence the detection sensitivity and detection time in biosensing applications.…”

Section: Introductionmentioning

confidence: 99%

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Borophene Quantum Dots with Enhanced Nanozymatic Activity for the Detection of H₂O₂ and Cardiac Biomarkers

Ahmed,

Sherazee,

Das

et al. 2023

ACS Appl. Nano Mater.

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Quantum dots with unconventional properties can bring massive opportunities in multidirectional applications. Herein, borophene quantum dots (BQDs) have been synthesized that exhibit nanozymatic activity in addition to their conventional fluorescence emission nature and antibacterial activity. Fluorescence emission peak position and decay time were 450 nm and 2.8 ns, respectively. The average size of the BQDs was 5.2 nm. A significant 5-fold enhancement of the nanozymatic activity of BQDs was observed through an electrochemical process that enabled H 2 O 2 detection with an exceptional limit of detection (LOD) value of 3.5 nM. A mechanism study revealed that two factors, for example, radical scavenging and electroassisted oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) have played significant roles in enhancing detection sensitivity and reducing detection time. BQDs possessed over 80% radical scavenging ability and, under an electrochemical field, demonstrated a 50-fold increase in the oxidation reaction of TMB compared with the conventional method. These remarkable findings were further utilized for the quantification of cholesterol and choline in a simulated blood sample with LOD values of 0.13 and 0.38 μM, respectively. The groundbreaking results presented in this study have the potential to open a pathway to move from the conventional nanozymatic detection method to an electroassisted one in the future.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Borophene Quantum Dots with Enhanced Nanozymatic Activity for the Detection of H₂O₂ and Cardiac Biomarkers

Ahmed,

Sherazee,

Das

et al. 2023

ACS Appl. Nano Mater.

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“…The thiocyanate group scavenged the radical, allowed most of the oxidation reaction to happen at the surface of GDY QDs, and oxidized TMB through several oxidation reactions (Scheme ). Ultimately, the radical scavenging activity of the thiocyanate group played a vital role in boosting the nanozymatic activity by originating the radical chain reaction and TMB oxidation. , To confirm the • OH radical formation and scavenging nature of thiocyanate-capped GYD QDs, the TA and DPPH test was performed. As shown in Figure S5A, a strong fluorescence peak (415 nm) with thiocyanate-capped GYD QDs appeared, confirming the formation of the • OH radical in the reaction media that reacted with TA and formed the fluorescent product 2-hydroxy TA.…”

Section: Resultsmentioning

confidence: 99%

Graphdiyne Quantum Dots for H₂O₂ and Dopamine Detection

Ahmed

Cardoso

Cobas

et al. 2023

ACS Appl. Nano Mater.

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The fluorescence and nanozymatic nature of quantum dots (QDs) in a single entity provide an excellent opportunity for the development of sensitive fluorescence and colorimetric biosensing and bioimaging approaches. Herein, the hydrothermal synthesis method of fluorescent graphdiyne quantum dots (GDY QDs) from graphdiyne sheets is presented. This research reports, for the first time, the nanozymatic activity of GDY QDs besides their conventional fluorescent nature, which catalyzes the oxidation of H 2 O 2 through the peroxidase biomimetic nature and enables detection of H 2 O 2 and dopamine. The peaks of the ultraviolet−visible (UV−vis) spectrum and the fluorescence emission of GDY QDs are located at 395 and 450 nm, respectively. The X-ray photoelectron spectroscopic (XPS) results reveal that GDY and GDY QDs have similar carbon skeletons. Moreover, the intensity of C−O and C�O peaks in GDY QDs is stronger than that of GDY, suggesting the successful surface oxidation of GDY, which is crucial for hydrophilicity and catalytic activity. Kinetic analysis reveals that as-synthesized GDY QDs exhibit Michaelis−Menten kinetic behavior. The terephthalic acid and DPPH test confirms the hydroxyl radical formation and scavenging nature of GDY QDs, playing a significant role in enhancing the nanozymatic activity. The biomimetic nature of GDY QDs is applied for H 2 O 2 and dopamine detection, and limit of detection (LOD) values of 0.13 and 8.65 μM are obtained for H 2 O 2 and dopamine, respectively. The findings of this study will open a door to the development of carbon-based nanocrystals with an enzyme-mimicking nature that can lead to the development of analytical approaches, in particular, colorimetric nanobiosensors.

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“…Photoluminescent nanomaterials have drawn a great deal of interest due to their immense applicability for a variety of purposes. For quite some time, scientists have been focusing on the development and analysis of quantum dots (QDs)a class of semiconductor nanomaterials with many advantages over dyes. − In particular, the distinctive emitted color of the QDs can be easily tuned by adjusting the particle size of the prepared nanocrystals. , Since “QDs” frequently contain toxic metallic compounds, their applications are restricted, especially for medicinal purposes . Hence, scientists are working to discover other less toxic or nontoxic alternative for photoluminescent nanostructures.…”

Section: Introductionmentioning

confidence: 99%

Waste-Derived Sustainable Fluorescent Nanocarbon-Coated Breathable Functional Fabric for Antioxidant and Antimicrobial Applications

Das

Sherazee

Marvi

et al. 2023

ACS Appl. Mater. Interfaces

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Hospital-acquired (nosocomial) infections account for the majority of adverse health effects during care delivery, placing an immense financial strain on healthcare systems around the world. For the first time, the present article provides evidence of a straightforward pollution-free technique to fabricate a heteroatom-doped carbon dot immobilized fluorescent biopolymer composite for the development of functional textiles with antioxidant and antimicrobial properties. A simple, facile, and ecofriendly approach was devised to prepare heteroatom-doped carbon dots from waste green tea and a biopolymer. The carbon dots showed an excitation-dependent emission behavior, and the XPS data unveiled that they are co-doped with nitrogen and sulfur. A facile physical compounding strategy was adopted to fabricate a carbon dot reinforced biopolymeric composite followed by immobilization onto the textile. The composite textiles revealed excellent antioxidant activity, determined by 1,1-diphenyl-2picrylhydrazyl (>80%) and 2,2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid assays (>90%). The results of the disc diffusion assay indicated that the composite textiles substantially inhibited the growth of both tested bacteria Escherichia coli and Bacillus subtilis with increasing coating cycles. The time-dependent antibacterial experiments revealed that the nanocomposite can inhibit significant bacterial growth within a few hours. The present study could open up the possibility for the commercialization of inexpensive smart textile substrates for the prevention of microbial contamination used for the medical and healthcare field.

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Nanozymatic detection of thiocyanate through accelerating the growth of ultra-small gold nanoparticles/graphene quantum dots hybrids

Cited by 19 publications

References 41 publications

Borophene Quantum Dots with Enhanced Nanozymatic Activity for the Detection of H₂O₂ and Cardiac Biomarkers

Borophene Quantum Dots with Enhanced Nanozymatic Activity for the Detection of H₂O₂ and Cardiac Biomarkers

Graphdiyne Quantum Dots for H₂O₂ and Dopamine Detection

Waste-Derived Sustainable Fluorescent Nanocarbon-Coated Breathable Functional Fabric for Antioxidant and Antimicrobial Applications

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Nanozymatic detection of thiocyanate through accelerating the growth of ultra-small gold nanoparticles/graphene quantum dots hybrids

Cited by 19 publications

References 41 publications

Borophene Quantum Dots with Enhanced Nanozymatic Activity for the Detection of H2O2 and Cardiac Biomarkers

Borophene Quantum Dots with Enhanced Nanozymatic Activity for the Detection of H2O2 and Cardiac Biomarkers

Graphdiyne Quantum Dots for H2O2 and Dopamine Detection

Waste-Derived Sustainable Fluorescent Nanocarbon-Coated Breathable Functional Fabric for Antioxidant and Antimicrobial Applications

Contact Info

Product

Resources

About

Borophene Quantum Dots with Enhanced Nanozymatic Activity for the Detection of H₂O₂ and Cardiac Biomarkers

Borophene Quantum Dots with Enhanced Nanozymatic Activity for the Detection of H₂O₂ and Cardiac Biomarkers

Graphdiyne Quantum Dots for H₂O₂ and Dopamine Detection