Nanozyme-Modified Metal–Organic Frameworks with Multienzymes Activity as Biomimetic Catalysts and Electrocatalytic Interfaces

Abstract

Many metal−organic frameworks have been designed and synthesized for biosensors because of high surface area and porosity, suitable size, and good biocompatibility. Despite recent advances, however, most of them are only used as a nanocarrier. In this work, a new artificial nanozyme was constructed on a metalloporphyrinic metal−organic framework (PMOF(Fe)), which was formed by Fe porphyrin and Zr 4+ ions. Then, ultrasmall Pt nanoparticles (Pt NPs) were loaded on the surface of PMOF(Fe) to form Pt@ PMOF(Fe). Because of the high surface area and exposed Fe activity center, PMOF(Fe) works as a nanocarrier to hinder the Pt NP aggregation and exhibits high peroxidase-mimicking activity. Hence, Pt NPs decorated on the surface of PMOF(Fe) possessed high stability and exhibited high activity. Due to the synergistic effect between PMOF(Fe) and Pt NPs, Pt@PMOF(Fe) exhibits superior catalase-and peroxidase-like activities. Moreover, Pt@PMOF(Fe) possesses high electrocatalytic activity toward the reduction of H 2 O 2 and the oxygen reduction reaction (ORR). This strategy may serve as a strong foundation to design MOF-based artificial nanozymes and develop an ideal platform for MOFs and nanozymes toward artificial enzymatic catalytic systems, fuel cells and new analytical applications.

Functionalized Graphene Fiber Modified With MOF-Derived Rime-Like Hierarchical Nanozyme for Electrochemical Biosensing of H2O2 in Cancer Cells

“…Then, the generated Cu 2 (OH)NO 3 are oxidized again to Cu 2 (OH) 3 NO 3 in the presence of H 2 O 2 . The mechanism process of Cu 2 (OH) 3 NO 3 @ZnO/AGF to catalyze the decomposition of H 2 O 2 can be presented as follows ( Ling et al, 2020 ): …”

The Application of Wearable Glucose Sensors in Point-of-Care Testing

“…Apart from colorimetric measurements ( Tian et al, 2016 ; de Castro et al, 2019 ), the non-enzymatic electrocatalytic reaction based on the metal–organic framework (MOF) is another stable way for glucose sensing, which displays higher sensitivity ( Ling et al, 2020 ; Wang et al, 2020 ). In particular, Wei group has made significant progress toward non-enzymatic quantitative detection of glucose ( Wei et al, 2021 ).…”

Synthesis, Catalytic Properties and Application in Biosensorics of Nanozymes and Electronanocatalysts: A Review

“…MOFs have high surface area and porosity, exposed active sites and good biocompatibility, and for these reasons they attact wide attention as a blooming alternative material. A multifunctional artificial enzyme was synthesized through a combination of the chemical reduction method and electrodeposition technique by modifying PtNPs on the metalloporphyrin MOF [40]. In the Pt@PMOF(Fe) complex, PMOF(Fe) could prevent the aggregation of PtNPs, leading to high stability of the Pt NPs.…”

“…Development of new nanocatalysts, including NZs, with higher catalytic activity expands their applications in bioanalytics. As a rule, the activity of NZs is lower than that of enzymes and their catalytic performance strongly depends on: (1) the method of synthesis (pH, reaction time and temperature) [25]; the composition of the nanomaterial [16,65]; the shape, size, dispersity and final morphology [66]; the mass ratio of the components in the nanocomposite [67]; and surface functionalization [40,[68][69][70].…”