Naphthalimides and analogues as antitumor agents: A review on molecular design, bioactivity and mechanism of action

Chen, Zhuo; Xu, Yufang; Qian, Xuhong

doi:10.1016/j.cclet.2018.09.020

Cited by 41 publications

(10 citation statements)

References 110 publications

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“…1,8-Naphthylimine and its extended π-conjugated system are well known as multifunctional fluorescent molecules that have been widely used in oncology treatment ( Banerjee et al, 2013 ; Tandon et al, 2017 ; Kumari et al, 2019 ). 1,8-Naphthylimine conjugation with anticancer drugs can enhance the cytotoxicity of the drugs ( Chen et al, 2018 ; Shanmugaraju et al, 2018 ; Tomczyk and Walczak, 2018 ; Jia et al, 2019 ; Ma et al, 2019 ). Based on this, photoactive Pt(IV) azide complexes 29a-c with axial 1,8-naphthalimide derivatives were developed ( Shi et al, 2021 ).…”

Section: Exo-stimuli-responsive Pt- and Ru-based Anticancer Drugsmentioning

confidence: 99%

Stimuli-responsive platinum and ruthenium complexes for lung cancer therapy

Zhang

Kang²,

Wang³

et al. 2022

Front. Pharmacol.

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Lung cancer is the most common cause of cancer-related deaths worldwide. More efficient treatments are desperately needed. For decades, the success of platinum-based anticancer drugs has promoted the exploration of metal-based agents. Four ruthenium-based complexes have also entered clinical trials as candidates of anticancer metallodrugs. However, systemic toxicity, severe side effects and drug-resistance impeded their applications and efficacy. Stimuli-responsiveness of Pt- and Ru-based complexes provide a great chance to weaken the side effects and strengthen the clinical efficacy in drug design. This review provides an overview on the stimuli-responsive Pt- and Ru-based metallic anticancer drugs for lung cancer. They are categorized as endo-stimuli-responsive, exo-stimuli-responsive, and dual-stimuli-responsive prodrugs based on the nature of stimuli. We describe various representative examples of structure, response mechanism, and potential medical applications in lung cancer. In the end, we discuss the future opportunities and challenges in this field.

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Section: Exo-stimuli-responsive Pt- and Ru-based Anticancer Drugsmentioning

confidence: 99%

Stimuli-responsive platinum and ruthenium complexes for lung cancer therapy

Zhang

Kang²,

Wang³

et al. 2022

Front. Pharmacol.

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“…The biological activity of those compounds is diverse ‐ covering anticancer, anti‐inflammatory, antibacterial, etc. bioeffects 10–14 . On the other hand, depending on the nature of the electron‐donor substituents in the naphthalene nucleus, they can absorb light energy and emit it as fluorescence in a wide spectral range, what facilitates their usage as PSs for photodynamic deactivation of pathogens 15–17 …”

Section: Introductionmentioning

confidence: 99%

“…bioeffects. [10][11][12][13][14] On the other hand, depending on the nature of the electron-donor substituents in the naphthalene nucleus, they can absorb light energy and emit it as fluorescence in a wide spectral range, what facilitates their usage as PSs for photodynamic deactivation of pathogens. [15][16][17] The highly branched structure of dendrimers and their unique properties have been attracting scientists' interest in viewing their antibacterial potential against various pathogenic microorganisms.…”

Section: Introductionmentioning

confidence: 99%

Enhancing the antibacterial activity of PAMAM dendrimer modified with 1,8‐naphthalimides and its copper complex via light illumination

Staneva

Manov

Vasileva−Tonkova

et al. 2022

Polymers for Advanced Techs

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This work describes the synthesis of a new photoactive PAMAM dendrimer of first generation, modified with 4‐dimethylamino‐1,8‐naphthalimide units and its complexation with Cu2+ ions. The photophysical characteristics of the two compounds in organic solvents of different polarity have been determined. The impact of light on reactive oxygen species from the new compounds and on the cotton fabrics dyed with them has been investigated by an iodometric method, consisting of I− transformation into I3−, which absorbs light at 288 and 352 nm. It has been determined that their antibacterial activity towards Gram‐negative and Gram‐positive bacteria enhances upon light illumination, as a resultant synergic effect of the biological activity of the new dendrimers and of the reactive oxygen they generate. The copper complex has been found to be more active than the ligand. Upon their loading onto cotton fabrics both compounds retain their antibacterial activity.

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“…[ 24 ] Naphthalimides and analogues can be applied as antitumor agents with the different mechanisms of action. [ 25 ]…”

Section: Introductionmentioning

confidence: 99%

Naphthalimide‐Based Fluorescent Polymers for Molecular Detection

Oshchepkov

Oshchepkova

et al. 2021

Advanced Optical Materials

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The beginning of the 21st century was marked by the intensive development of fiber‐optic sensors. New functional materials with excellent sensory properties are required to design such sensors. Fluorescent probes for neutral and charged molecules are constantly developing. However, only a small part of the reported probes was successfully converted into functional sensing polymers and found real‐world applications. A great challenge is to retain the sensing properties of a probe in a polymer matrix. The purpose of this review is to understand how properties of a probe are changed upon incorporation into a polymer and to reveal successful approaches. The review focuses on the use of the naphthalimide‐based probes in the construction of sensing polymers. The literature overview is presented according to the nature of the guest molecules targeted for the quantitative detection: cations, anions, and small organic molecules.

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Naphthalimides and analogues as antitumor agents: A review on molecular design, bioactivity and mechanism of action

Cited by 41 publications

References 110 publications

Stimuli-responsive platinum and ruthenium complexes for lung cancer therapy

Stimuli-responsive platinum and ruthenium complexes for lung cancer therapy

Enhancing the antibacterial activity of PAMAM dendrimer modified with 1,8‐naphthalimides and its copper complex via light illumination

Naphthalimide‐Based Fluorescent Polymers for Molecular Detection

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