Naphthofluorescein-based organic nanoparticles with superior stability for near-infrared photothermal therapy

An, Jing; Tang, Shanliang; Feng, Enmin; Tian, Mingyu; Chen, Wenlong; Chen, Miaomiao; Hong, Gaobo; Peng, Xiaojun; Song, Fengling

doi:10.1039/d2nr02284b

Nanoscale

2022

DOI: 10.1039/d2nr02284b

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Naphthofluorescein-based organic nanoparticles with superior stability for near-infrared photothermal therapy

Jing An

Shanliang Tang

Enmin Feng

et al.

Abstract: Photothermal agents (PTAs) based on organic small molecules with near-infrared (NIR) absorption (700 – 900 nm) have attracted increasing attention in cancer photothermal therapy (PTT). However, NIR organic PTAs often...

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Cited by 5 publications

References 49 publications

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Ultrabright Dibenzofluoran‐Based Polymer Dots with NIR‐IIa Emission Maxima and Unusual Large Stokes Shifts for 3D Rotational Stereo Imaging

Chowdhury,

Lu,

et al. 2024

Adv Healthcare Materials

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Emerging organic molecules with emissions in the NIR‐II region are garnering significant attention. Unfortunately, achieving accountable organic emission intensity over the NIR‐IIa (1300 nm) region faces challenges due to the intrinsic energy gap law. Up to current stage, all reported organic NIR‐IIa emitters belong to polymethine‐based dyes with small Stokes shifts (< 50 nm) and low quantum yield (≤ 0.015%). However, such polymethines have proved to cause self‐absorption with constrained emission brightness, limiting advanced development in deep‐tissue imaging. Here we design a new NIR‐IIa scaffold based on rigid and highly conjugated dibenzofluoran core terminated by amino‐containing moieties that reveal emission peaks of 1230–1305 nm. The quantum yield is at least 10 times higher than all synthesized or reported NIR‐IIa polymethines (Figure 1) with extraordinarily large Stokes shifts of 370–446 nm. DBF‐BJ was further prepared as a polymer dot to demonstrate its in vivo 3D stereo imaging of mouse vasculature with a 1400 nm long‐pass filter.This article is protected by copyright. All rights reserved

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Ultrabright Dibenzofluoran‐Based Polymer Dots with NIR‐IIa Emission Maxima and Unusual Large Stokes Shifts for 3D Rotational Stereo Imaging

Chowdhury,

Lu,

et al. 2024

Adv Healthcare Materials

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Easy but Efficient: Facile Approach to Molecule with Theoretically Justified Donor–Acceptor Structure for Effective Photothermal Conversion and Intravenous Photothermal Therapy

Zhong,

Huang,

Zhao

et al. 2024

Advanced Science

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To accelerate the pace in the field of photothermal therapy (PTT), it is urged to develop easily accessible photothermal agents (PTAs) showing high photothermal conversion efficiency (PCE). As a proof‐of‐concept, hereby a conventional strategy is presented to prepare donor–acceptor (D–A) structured PTAs through cycloaddition‐retroelectrocyclization (CA–RE) reaction, and the resultant PTAs give high PCE upon near‐infrared (NIR) irradiation. By joint experimental‐theoretical study, these PTAs exhibit prominent D–A structure with strong intramolecular charge transfer (ICT) characteristics and significantly twisting between D and A units which account for the high PCEs. Among them, the DMA‐TCNQ exhibits the strongest absorption in NIR range as well as the highest PCE of 91.3% upon irradiation by 760‐nm LED lamp (1.2 W cm−2). In vitro and in vivo experimental results revealed that DMA‐TCNQ exhibits low dark toxicity and high phototoxicity after IR irradiation along with nude mice tumor inhibition up to 81.0% through intravenous therapy. The findings demonstrate CA–RE reaction as a convenient approach to obtain twisted D–A structured PTAs for effective PTT and probably promote the progress of cancer therapies.

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Recent advances in the design of organic photothermal agents for cancer treatment: A review

Lee,

Min,

Kim

et al. 2024

Coordination Chemistry Reviews

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Naphthofluorescein-based organic nanoparticles with superior stability for near-infrared photothermal therapy

Abstract: Photothermal agents (PTAs) based on organic small molecules with near-infrared (NIR) absorption (700 – 900 nm) have attracted increasing attention in cancer photothermal therapy (PTT). However, NIR organic PTAs often...

Cited by 5 publications

References 49 publications

Ultrabright Dibenzofluoran‐Based Polymer Dots with NIR‐IIa Emission Maxima and Unusual Large Stokes Shifts for 3D Rotational Stereo Imaging

Ultrabright Dibenzofluoran‐Based Polymer Dots with NIR‐IIa Emission Maxima and Unusual Large Stokes Shifts for 3D Rotational Stereo Imaging

Easy but Efficient: Facile Approach to Molecule with Theoretically Justified Donor–Acceptor Structure for Effective Photothermal Conversion and Intravenous Photothermal Therapy

Recent advances in the design of organic photothermal agents for cancer treatment: A review

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