Naphthohydroquinones, naphthoquinones, anthraquinones, and a naphthohydroquinone dimer isolated from the aerial parts of Morinda parvifolia and their cytotoxic effects through up-regulation of p53

Kang, Jie; Zhang, Peng; Gao, Zhuye; Zhang, Jian; Zheng, Yan; Wang, Hongqing; Chen, Ruo-Yun

doi:10.1016/j.phytochem.2016.04.001

Cited by 23 publications

(7 citation statements)

References 21 publications

(21 reference statements)

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“…Methods applied for extracting quinones include maceration [116], reflux [117], Soxhlet [118,119], microwave assisted [118,120,121], ultrasonic assisted [118,122], ultrasonic-microwave assisted [123], enzyme assisted [37,124], supercritical fluid [125], sublimation assisted [38], and pressurised liquid [121,126] extractions. The applicability, requirements and results vary considerably among these methods.…”

Section: Extraction Methodsmentioning

confidence: 99%

“…Anthraquinone sources under active study for dyeing purposes include Rubia cordifolia, and Rubia tinctorum which contains alizarin, purpurin, emodin and rhein as common pigments [36,37]; Rheum emodi which contains contains emodin and physcion colourants [38]; Cassia nodosa, which contains rhein [39]; and Morinda angustifolia, which contains rhein and emodin dye compounds [40]. Anthraquinone pigments have been isolated in concentrations in excess of 30 mg/(g dw) (dw: dry weight) from Morinda citrifolia, R. emodi, Rheum undulatum, Rubia cardigolia and Tectona grandis [38,41,42].…”

Section: Occurrencementioning

confidence: 99%

See 1 more Smart Citation

Natural Quinone Dyes: A Review on Structure, Extraction Techniques, Analysis and Application Potential

Dulo

Phan

Githaiga

et al. 2021

Waste Biomass Valor

105

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Synthetic dyes are by far the most widely applied colourants in industry. However, environmental and sustainability considerations have led to an increasing efforts to substitute them with safer and more sustainable equivalents. One promising class of alternatives is the natural quinones; these are class of cyclic organic compounds characterized by a saturated (C6) ring that contains two oxygen atoms that are bonded to carbonyls and have sufficient conjugation to show color. Therefore, this study looks at the potential of isolating and applying quinone dye molecules from a sustainable source as a possible replacement for synthetic dyes. It presents an in-depth description of the three main classes of quinoid compounds in terms of their structure, occurrence biogenesis and toxicology. Extraction and purification strategies, as well as analytical methods, are then discussed. Finally, current dyeing applications are summarised. The literature review shows that natural quinone dye compounds are ubiquitous, albeit in moderate quantities, but all have a possibility of enhanced production. They also display better dyeability, stability, brightness and fastness compared to other alternative natural dyes, such as anthocyanins and carotenoids. Furthermore, they are safer for the environment than are many synthetic counterparts. Their extraction, purification and analysis are simple and fast, making them potential substitutes for their synthetic equivalents. Graphic Abstract

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Section: Extraction Methodsmentioning

confidence: 99%

Section: Occurrencementioning

confidence: 99%

Natural Quinone Dyes: A Review on Structure, Extraction Techniques, Analysis and Application Potential

Dulo

Phan

Githaiga

et al. 2021

Waste Biomass Valor

105

View full text Add to dashboard Cite

show abstract

“…Its fruits are of compound berry type (Ruan, ; Table ). The decoction of aerial parts is used in enhancement of the body functions and activities (Kang et al, ; Table ). The distribution of M. reticulata has been reported from the Kearla and Tamil Nadu states of India (Nair & Gangaprasad, ).…”

Section: Botany and Ethnomedicinal Uses Of Indian Morinda Speciesmentioning

confidence: 99%

Indian Morinda species: A review

Singh

Sharma

2019

Phytotherapy Research

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Morinda is a largest genus of Rubiaceae family, and its 11 species are found in India.In India, plant species are known by several common names as great morinda, Indian mulberry, noni, beach mulberry and cheese fruit. Various Morinda products (capsules, tablets, skin products and fruit juices) are available in the market, used by people for treatment of several health complaints. A diversity of phytochemicals including iridoids, flavonoids, flavonoid glycosides, anthraquinones, coumarins, lignanas, noniosides, phenolics and triterpenoids have been reported from Morinda species. Morinda species are used in the treatment of inflammation, cancer, diabetes, psyquiatric disorders, and bacterial and viral infections. The noni fruit juice (Morinda citrifolia) and its products are used clinically in the treatment of cancer, hypertension and cervical spondylosis affecting patients. M. citrifolia fuit juice, with different doses, is used in the maintaining blood pressure and reducing of superoxides, HDL and LDL levels. Similarly, oligosaccharide capsules and tablets of root extract of M. officinalis are recommended as medicine for the treatment of kidney problems and sexual dysfunctions of patients. The toxicological studies revealed that higher doses of fruit juice (4,000 or 5,000 mg/kg) of M. citrifolia for 2 or more months cause toxic effects on liver and kidneys. M. officinalis root extracts (ethanolic and aqueous) are found fully safe during treatment of diseases. A large number of reviews are available on M. citrifolia but very few studies are conducted on other Indian Morinda species. This review reports the comprehensive knowledge on state-wise distribution, botany, ethnomedicinal uses, phytochemistry, pharmacological activities, clinical applications and toxicological evaluations of 11 species of Morinda found in India.

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“…Bourgou and colleagues reported that the EAF is effective against cell proliferation in HeLa cell [30]. This is primarily due to the presence of cytotoxic compounds in EAF including caffeoylquinic acid derivatives such as di and tri-caffeoylquinic acid, napthoquinone derivatives [74], and santonin -a sesquiterpene lactone [75]. The mechanism of EAF anticancer activity is through the production of ROS and the induction of apoptosis via the mitochondria dependent pathway [30].…”

Section: Ethyl Acetate Fraction (Eaf) Of Artemisia Herba Alba: Lc-esi-tof-ms and Gc-ei-ms Profiling Of Artemisiamentioning

confidence: 99%

Functional foods’ bioactive components and their chemoprevention mechanism in cervical, breast, and liver cancers: A systematic review

Teibo

Ayinde

Olaoba

et al. 2021

FFHD

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The invasiveness and low survivability on the part of patients associated with cancer continues to raise global concern. Different approaches have been used in the treatment and restoration of normalcy in cancer patients. However, most of the therapeutic strategies employed are challenged with high cost, low efficacy, high toxicity, and multiple side effects. In recent times, emergent studies have provided evidence that functional foods and their bioactive components serve roles as potential agents in the prevention and treatment of cancers. Moreover, global interest has focused on how this chemoprevention potential of functional foods can be explored as plant-based medicines for drug development. Although, the literature is replete with the mechanism of chemoprevention elicited by individual components of functional foods, there are limited reports on their overall anti-cancer mechanisms. Therefore, this systematic review aims to unify the anti-cancer mechanisms of functional foods in cervical, breast, and liver cancers which were selected due to their high incidence and mortality globally. We reviewed articles from NCBI/PUBMED from 2010 until February 2020. Three different search words used include “Functional food and cervical cancer”; “Functional foods and breast cancer”; “Functional foods and hepatocarcinoma”. Consequently, 434 scientific papers resulted from the three search words. However, after applying the inclusion/exclusion criteria, 37 articles were selected: 14 on cervical cancer, 10 on breast cancer, and 13 on hepatocellular carcinoma. We subsequently emphasize the anti-cancer mechanisms of various functional foods in the studies selected and these include induction of apoptosis, cell cycle arrest, disruption of microtubular network, downregulation of anti-apoptotic Bcl-2 family expression, induction of autophagy, modulation of signaling cascades, ROS generation, and suppression of specific genes. Therefore, functional foods possess effective chemoprevention mechanisms which can be explored in drug development. Keywords: Cervical cancer, Breast cancer, Liver cancer, Cancer prevention, Functional foods, Bioactive compounds

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Naphthohydroquinones, naphthoquinones, anthraquinones, and a naphthohydroquinone dimer isolated from the aerial parts of Morinda parvifolia and their cytotoxic effects through up-regulation of p53

Cited by 23 publications

References 21 publications

Natural Quinone Dyes: A Review on Structure, Extraction Techniques, Analysis and Application Potential

Natural Quinone Dyes: A Review on Structure, Extraction Techniques, Analysis and Application Potential

Indian Morinda species: A review

Functional foods’ bioactive components and their chemoprevention mechanism in cervical, breast, and liver cancers: A systematic review

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