Naproxen-Associated Linear IgA Bullous Dermatosis: Case Report and Review

Abstract

Linear IgA bullous dermatosis (LABD) is an acquired autoimmune subepidermal blistering disorder in which linear deposits of IgA are found along the basement membrane. Idiopathic, systemic disorder-related, and drug-induced forms of LABD have been described. Drug-induced LABD occurs in association with drug administration and resolves when the offending agent is discontinued. Other forms of LABD assume a more chronic course. The nonsteroidal anti-inflammatory drugs piroxicam and diclofenac have been previously reported to induce LABD. To our knowledge, this article describes the first documented case of LABD associated with naproxen administration, which resolved after discontinuation of the drug.

Linear IgA bullous dermatosis: report of five cases in Chile

“…LABD is classically idiopathic, but a drug‐induced variant seems to be individualized in which cutaneous lesions resolve spontaneously after cessation of the responsible drug 10 . The drug most frequently implicated is vancomycin, 11 but other drugs have been implicated, including phenytoin, 12 amiodarone, 13 captopril, 14 and non‐steroid inflammatory agents 15 . Our series confirms that association; two of our patients had a history of non‐steroid inflammatory consumption as the precipitant event for LABD.…”

Linear IgA bullous dermatosis: comparison between the drug-induced and spontaneous forms

“…5,6 LABD is usually spontaneous or drug induced, the first case of drug-induced LABD being described in 1981. 7 Vancomycin has been the most frequently reported culprit drug, 8,9 but other drugs have been incriminated, including amiodarone, 10 nonsteroidal anti-inflammatory drugs (piroxicam, naproxen), 11,12 acetaminophen 13 and antibiotics (ceftriaxone, penicillin), 14,15 with a 2-day to 4-week time to onset. Recently, the concept of drug-induced LABD was questioned.…”

Dermatosis ampollar por inmunoglobulina A lineal. Reporte de dos casos

“…[7][8][9] En algunos casos, se puede demostrar la relación causal con algún fármaco; el más frecuentemente implicado es la vancomicina, betalactámicos, antiinflamatorios o fenitoína, con reaparición de las lesiones al tomar de nuevo la droga sospechosa. [10][11][12] El curso clínico característico consiste en la aparición aguda de ampollas sobre zonas de piel inflamada o sana, con extensión hacia la zona periférica de lesiones más antiguas, lo que da un aspecto arrosariado. En pediatría, es típica la localización en el tronco, la cara, sobre todo perioral, las manos y los pies, y en especial, la zona baja del abdomen periné y la cara interna de los muslos.…”