Naproxen premedication reduces postoperative tubal ligation pain

Comfort, V. Kim; Code, William E.; Rooney, Michael E.; Yip, Raymond W.

doi:10.1007/bf03009045

Cited by 84 publications

(23 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…7 Diclofenac has been shown to provide effective pain relief in inflammatory joint disease, renal colic and, more recently, in the control of pain following surgery. [8][9][10][11][12][13] Since post-laparoscopy pain may be due to distention of the peritoneal cavity resulting in peritoneal inflammation, 2 diclofenac may act not only through its analgesic but also its anti-inflammatory properties. This hypothesis is further supported because only the late pain was affected by diclofenac and that ketorolac (NSAID with less anti-inflammatory properties than diclofenac) failed to reduce post-laparoscopy pain.…”

Section: Discussionmentioning

confidence: 99%

Preoperative diclofenac sodium reduces postlaparoscopy pain

Gillberg¹,

Harsten²,

Stähl³

1993

Can J Anaesth

View full text Add to dashboard Cite

Post-laparoseopy pain can increase recovery time and delay patient discharge. While previous studies have focused on the problems of nausea and vomiting, the purpose of this study was to assess the effect of diclofenac (a non-steroidal antiinflammatory drug) Krisfianstad County Council provided financial support. Ciba-Geigy, Sweden, supplied the diclofenac and placebo used in this study.Accepted for publication 5th January, 1993. Le diclofdnac produit un meilleur soulagement it 24 hres (1,0 vs 2,5, P < 0,05) et diminue le nombre de patientes qui ont besoin d'analgdsiques additionnels (7 vs 15, P < 0,05). 17 n'y a pas de difference dans Hncidence des effets secondaires. Ces donn~es suggbrent que le diclofdnac diminue la douleur postlaparoscopie et les besoins postop~ratoires d'analg~siques.In many patients post-laparoscopy pain is severe and difficult to manage. ~ In a recent study, peritoneal biopsy, performed two or three days after laparoscopy, showed peritoneal inflammation resulting from capillaries which were torn at the time that the abdomen was distended with gas. In the same study a linear relationship was found between abdominal compliance at the time of laparoscopy and the severity of postoperative pain. 2 Postoperative pain control using non-steroidal antiinflammatory drugs (NSAIDs) may reduce peritoneal inflammation and consequently reduce the pain. The purpose of this study was to assess the analgesic efficacy of rectally administered diclofenac before surgery on postoperative pain following gynaecological laparoscopy. MethodsAfter approval of the protocol by the Ethical Committee of the Faculty of Medicine of the University of Lund, informed written consent was obtained from 49 women, ASA I-II, who required laparoscopic surgery. If laparotomy was performed, the patient was excluded from the study. Each patient was allocated to one of the study groups according to a random number sequence. ProcedureAll patients underwent laparoscopy with general anaesthesia. Sixty minutes before induction of anaesthesia meperidine 75 mg (Petidin, Kabi, Sweden) was given On. At the same time diclofenac sodium 50 mg (Voltaren/ Voltarol, Ciba-Geigy, Basle) or placebo was administered pr to the patient in a randomized double-blind manner. The ECG monitored continuously. After glycopyrrolate 3 ~g" kg -I (Robinul, Robins, UK) anaesthesia was induced with fentanyl, 1 ~tg. kg -I (Leptanal, Janssen Pharmaceutica, Belgium), followed by thiopentone, 4-5 mg. kg -1 (Pentothal, Abbot, US). Tracheal intubation CAN J ANAESTH 1993 / 40:5 / pp406--8

show abstract

Section: Discussionmentioning

confidence: 99%

Preoperative diclofenac sodium reduces postlaparoscopy pain

Gillberg¹,

Harsten²,

Stähl³

1993

Can J Anaesth

View full text Add to dashboard Cite

show abstract

“…2-4 However, it is well established that pain therapy should begin as early as possible in the postoperative period, if not preemptively before surgery. 5,6 Morphine is widely used for postoperative pain relief. However, drug requirements to obtain analgesia show great interindividual variability.…”

Section: Ce Travail Prospectif Avait Pour Objectif D~valuer L'efficacmentioning

confidence: 99%

Can immediate opioid requirements in the post-anaesthesia care unit be used to determine analgesic requirements on the ward?

1995

View full text Add to dashboard Cite

Can immediate opioid requirements in the post-anaesthesia care unit be used to determine analgesic requirements on the wardg.The aim of this prospective study was to evaluate the efficacy of two dosage regimens of (ira) morphine calculated from an initial (iv) titrated dose in the early postoperative period. Seventy ASA 1-111 patients who underwent general anaesthesia (GA) (n = 58), regional anaesthesia (RA) (n = 10) or GA + RA (n = 2) for orthopaedic (n = 54), urological (n = 11) or abdominal surgery (n = 5) received iv titrated morphine in the post-anaesthesia care unit (PACU). Titration consisted of 3 mg morphine iv every ten minutes until patients had a visual analogue pain scale (VAS) <3, without marked sedation. Seventeen patients did not complain at all or had good analgesiawith an initial iv dose _<6 mg of morphine followed by paracetamol only. Patients who needed more than 6 mg iv morphine were randomly assigned to a "high-dose" or a "low-dose" group and received a systematic im morphine regimen calculated from the initial titrated dose. Pain was assessed by VAS before each im injection and the next morning. One patient had respiratory depression and one marked sedation in the PACU These patients were excluded from the rest of the study. Only 16patients had a VAS >3 at least once during the study period and only three needed rescue analgesia which was avail-

show abstract

“…Mixed results from preceding studies have been unable to unanimously support the preemptive use of NSAIDs with this surgical population (Brodie & Casper, 1985;Cabell, 2000;Cade & Kakulas, 1995;Comfort, Code, Rooney, & Yip, 1992;Edwards et al, 1991;Higgins, Givogre, Marco, Blumenthal, & Furman, 1994;Kelly et al, 1994). Information gleaned fi-om this study pertaining to the preemptive effects of ketorolac and ibuprofen could have clinical implications.…”

Section: Significancementioning

confidence: 93%

“…If the suppositories had been given at least one hour prior to induction, there may have been an even greater reduction in the amount of pain postoperatively. Comfort et al (1992) undertook a similar double-blind, randomized, placebocontrolled clinical trial on patients undergoing outpatient laparoscopic tubal ligations.…”

Section: Pain From Tubal Sterilizationmentioning

confidence: 99%

A Comparison of Postoperative Pain With Preemptive Administration of Intravenous Ketorolac Versus Oral Ibuprofen in Patients Undergoing Interval Laparoscopic Bilateral Tubal Sterilization

Harm¹,

Gibbons²

2000

PsycEXTRA Dataset

View full text Add to dashboard Cite

Public fepprting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing date sources, gathering Bird maintaining the data needed, and comp'eting end reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of iniormfltion, including suggestions for reducing this burden, to WasNngton Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arfington, VA 22202-4302, and to the Office of Management and Budget, Paperwork Reduction Project (0704-0188), Washington, DC 20503. AGENCY USE ONLY (Leave blank)2. REPORT DATE October 2000 REPORT TYPE AND DATES COVEREDOctober 1999 -September 2000 TITLE AND SUBTITLEA comparison of postoperative pain with reemptive administration of intravenous ketorolac versus oral ibuprofen in patients undergoing interval lapatoscopic bilateral tubal sterilization AUTHDRIS)CPT Patricia S. Harm CPT Michael T. Gibbons FUNDING NUMBERS PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES)University A major goal of anesthesia practitioners is to provide a comfortable and expedient recovery from the effects of surgery and anesthesia. This includes the challenge fostered by managed-care of facilitating earlier discharges while also managing postoperative pain. Moreover, consumer knowledge and techological advances are pressing the health care community to seek higher levels of patient satisfaction and cost containment. Elective surgery patients are acquirmg greater expectations regarding the perioperative care they receive, which includes absence of recall, minmial pain or discomfort, and absence of nausea following surgery. Each year over 10 million women m the United States alone elect to have surgical sterilization. This is usuall accomplished laparoscopically despite the problems of post-laparoscopic pain, which ca|Ebe servre enough to warrant an unplanned admission. Ketorolac and ibuprofen have both been studied in this patient popAion when given preemptively with mixed results; presently there is no conclusive evidence as to which drug is mor^fpfective. This prospective, randomized, double-blind clinic trial compared the effects over time when these patie|i received ketorolac or ibuprofen preemptively. The sam was comprised of 44 subjects undergoing laparoscopic tubal ligaibn under general endotracheal anesthesia at a regional military medical center for the Pacific Rim. The patients were either ASA category I or II and at least 18 years of age assigned to one of two treatment groups. Group I received 800 mg ibuprofen orally and a 1 ml saline placebo intravenously; conversely. Group II received an oral placebo and ketorolac 30 mg intravenously. Postoperative pain was assessed using an 11 point Numeric Rating Scale (NRS) at seven time intervals. A major goal of anesthesia practitioners is to provide a comfortable and expedient recovery from the effects of surgery and anesthesia....

show abstract

Naproxen premedication reduces postoperative tubal ligation pain

Cited by 84 publications

References 8 publications

Preoperative diclofenac sodium reduces postlaparoscopy pain

Preoperative diclofenac sodium reduces postlaparoscopy pain

Can immediate opioid requirements in the post-anaesthesia care unit be used to determine analgesic requirements on the ward?

A Comparison of Postoperative Pain With Preemptive Administration of Intravenous Ketorolac Versus Oral Ibuprofen in Patients Undergoing Interval Laparoscopic Bilateral Tubal Sterilization

Contact Info

Product

Resources

About