Naproxen release behaviour from graphene oxide/cellulose acetate composite nanofibers

Purnamasari, Wulan; Budiastanti, Titah Aldila; Aminatun, Aminatun; Rahmah, Ulfa Indah Laela; Sumarsih, Sri; Chang, Jia‐Yaw; Fahmi, Mochamad Zakki

doi:10.1039/d1ra09293f

Cited by 13 publications

(10 citation statements)

References 47 publications

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“…In 60 and 70% methanol aqueous solutions, the value of n is 0.3304 and 0.2630 ( n < 0.45) for the dissolution of the CD-MOF⊃FL crystal, respectively, implying that the dissolution of the CD-MOF⊃FL crystal maintained a Fickian behavior (case I transport) governed by tiny swelling and diffusion . In 75% methanol aqueous solution, n is 0.745 (0.45 < n < 0.89), indicating that the dissolution of the CD-MOF⊃FL crystal followed a non-Fickian behavior, controlled by both diffusion and erosion. , In 80 and 95% methanol aqueous solutions, n is 1.037 and 4.927 ( n > 0.89), respectively, indicating that the dissolution of the CD-MOF⊃FL crystal exhibited a Fickian behavior (case II transport) controlled by erosion …”

Section: Resultsmentioning

confidence: 99%

Tracking the Dissolution Surface Kinetics of a Single Fluorescent Cyclodextrin Metal–Organic Framework by Confocal Laser Scanning Microscopy

Zhou

Feng

et al. 2023

Langmuir

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The understanding of the dissolution processes of solids is important for the design and synthesis of solids in a controlled and precise manner and for predicting their fate in the aquatic environment. We report herein single-particle-based confocal laser scanning microscopy (CLSM) for tracking the dissolution surface kinetics of a single fluorescent cyclodextrin metal−organic framework (CD-MOF). As a proof of concept, CD-MOF containing fluorescein, named as CD-MOF⊃FL, was synthesized by encapsulating fluorescein into the interior of CD-MOF via a vapor diffusion method and used as a single-particle dissolution model because of its high FL efficiency and unique structure. The morphology of CD-MOF⊃FL and the distribution of fluorescein within CD-MOF⊃FL were characterized. The growth and dissolution processes of CD-MOF⊃FL at the single-particle level were visualized and quantified for the first time by recording the change of the fluorescence emission. Three processes, including nucleation, germination growth, and saturation stage, were found in the growth of CD-MOF⊃FL, and the growth kinetics followed Avrami's model. The dissolution rate at the face of a single CD-MOF⊃FL crystal was slower than that of its arris, and the dissolution rate of the CD-MOF⊃FL crystal was increased with the increase of the water amount in methanol solution. The dissolution process of the CD-MOF⊃FL crystal was a competitive process of erosion and diffusion in different methanol aqueous solutions, and the dissolution kinetics followed the Korsmeyer−Peppas model. These results offer new insights into the nature of dissolution kinetics of CD-MOF⊃FL and provide new venues for the quantitative analysis of solid dissolution and growth at the single-particle level.

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Section: Resultsmentioning

confidence: 99%

Tracking the Dissolution Surface Kinetics of a Single Fluorescent Cyclodextrin Metal–Organic Framework by Confocal Laser Scanning Microscopy

Zhou

Feng

et al. 2023

Langmuir

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“…The antimicrobial activity took place through the combined capability of TiO 2 and GO of increasing the ROS-mediated oxidative stress and leading to cell death [ 141 ] on one hand; and the possible interference of Cur with the FtsZ protein functions, involved in bacterial cytokinesis, on the other hand, resulting in the bacterial growth inhibition [ 142 , 143 ]. Finally, the GO/TiO 2 /CA nanofibers not only proved to be biocompatible, but above all they demonstrated to promote the NIH3T3 fibroblasts proliferation and migration, helping in the closure of wounds of 77% already at 12 h. On the other hand, Purnamasari et al investigated the potential improvements achieved by simultaneous incorporation of GO and a commercial drug, such as Naproxen (NA), in CA-based hydrogel formulation processed in the form of nanofibers by electrospinning [ 132 ]. GO fillers enhanced the mechanical strength of the fibres, driving the production of fibres with a lower diameter (≈447 nm), higher conductivity (1.5 µS/cm) and keeping the NA onto the nanofiber.…”

Section: Go-functionalised Cellulose-based Nanocomposites For Wound H...mentioning

confidence: 99%

Advances in the Physico-Chemical, Antimicrobial and Angiogenic Properties of Graphene-Oxide/Cellulose Nanocomposites for Wound Healing

et al. 2023

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Graphene oxide (GO) and its reduced form (rGO) have recently attracted a fascinating interest due to their physico-chemical properties, which have opened up new and interesting opportunities in a wide range of biomedical applications, such as wound healing. It is worth noting that GO and rGO may offer a convenient access to its ready dispersion within various polymeric matrices (such as cellulose and its derivative forms), owing to their large surface area, based on a carbon skeleton with many functional groups (i.e., hydroxyl, carboxyl, epoxy bridge, and carbonyl moieties). This results in new synergic properties due to the presence of both components (GO or rGO and polymers), acting at different length-scales. Furthermore, they have shown efficient antimicrobial and angiogenic properties, mostly related to the intracellular formation of reactive oxygen species (ROS), which are advantageous in wound care management. For this reason, GO or rGO integration in cellulose-based matrixes have allowed for designing highly advanced multifunctional hybrid nanocomposites with tailored properties. The current review aims to discuss a potential relationship between structural and physico-chemical properties (i.e., size, edge density, surface chemistry, hydrophilicity) of the nanocomposites with antimicrobials and angiogenic mechanisms that synergically influence the wound healing phenomenon, by paying particular attention to recent findings of GO or rGO/cellulose nanocomposites. Accordingly, after providing a general overview of cellulose and its derivatives, the production methods used for GO and rGO synthesis, the mechanisms that guide antimicrobial and angiogenic processes of tissue repair, as well as the most recent and remarkable outcomes on GO/cellulose scaffolds in wound healing applications, will be presented.

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“…Spinning techniques such as wet-spinning and electrospinning were recently applied to produce functionalized GO/CNFs hybrids. 173,181 For example, using a wet-spinning process, Yu et al produced a hybrid using GO and carboxymethyl cellulose nanofibrils. They assessed it as an adsorbent for elimination of heavy metal ions in wastewater treatment.…”

Section: Strategies To Prepare Functionalized Cnfs/gnms Hybrids Their...mentioning

confidence: 99%

Cellulose nanofibrils–graphene hybrids: recent advances in fabrication, properties, and applications

et al. 2022

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Naproxen release behaviour from graphene oxide/cellulose acetate composite nanofibers

Abstract: The present study investigated the effect of graphene oxide in cellulose acetate-based composite nanofibers on the transdermal delivery of naproxen.

Cited by 13 publications

References 47 publications

Tracking the Dissolution Surface Kinetics of a Single Fluorescent Cyclodextrin Metal–Organic Framework by Confocal Laser Scanning Microscopy

Tracking the Dissolution Surface Kinetics of a Single Fluorescent Cyclodextrin Metal–Organic Framework by Confocal Laser Scanning Microscopy

Advances in the Physico-Chemical, Antimicrobial and Angiogenic Properties of Graphene-Oxide/Cellulose Nanocomposites for Wound Healing

Cellulose nanofibrils–graphene hybrids: recent advances in fabrication, properties, and applications

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