Naringenin ameliorates diabetic neuropathic pain by modulation of oxidative-nitrosative stress, cytokines and MMP-9 levels

Singh, Pratishtha; Bansal, Seema; Kuhad, Anurag; Kumar, Anil; Chopra, Kanwaljit

doi:10.1039/c9fo00881k

Cited by 37 publications

(17 citation statements)

References 53 publications

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“…Evidence-Based Complementary and Alternative Medicine inflammatory, antioxidant, and neuroprotective effects that could improve neuropathic pain, neuronal damage, and injury [119,303,304]. Glycyrrhizin and naringenin reduce inflammatory and neuropathic pain-like behaviors by modulating the secretion of inflammation-associated cytokines and mediators, as well as the activities of cyclic guanosine monophosphate (cGMP) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signalings [120,301,[305][306][307][308][309][310][311][312][313][314]. Isoliquiritigenin was reported to possess analgesic, antispasmodic, and relaxant properties [315,316].…”

Section: Discussionmentioning

confidence: 99%

An Investigation of the Molecular Mechanisms Underlying the Analgesic Effect of Jakyak‐Gamcho Decoction: A Network Pharmacology Study

Lee¹,

Kang

Park³

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Herbal drugs have drawn substantial interest as effective analgesic agents; however, their therapeutic mechanisms remain to be fully understood. To address this question, we performed a network pharmacology study to explore the system-level mechanisms that underlie the analgesic activity of Jakyak-Gamcho decoction (JGd; Shaoyao-Gancao-Tang in Chinese and Shakuyaku-Kanzo-To in Japanese), an herbal prescription consisting of Paeonia lactiflora Pallas and Glycyrrhiza uralensis Fischer. Based on comprehensive information regarding the pharmacological and chemical properties of the herbal constituents of JGd, we identified 57 active chemical compounds and their 70 pain-associated targets. The JGd targets were determined to be involved in the regulation of diverse biological activities as follows: calcium- and cytokine-mediated signalings, calcium ion concentration and homeostasis, cellular behaviors of muscle and neuronal cells, inflammatory response, and response to chemical, cytokine, drug, and oxidative stress. The targets were further enriched in various pain-associated signalings, including the PI3K-Akt, estrogen, ErbB, neurotrophin, neuroactive ligand-receptor interaction, HIF-1, serotonergic synapse, JAK-STAT, and cAMP pathways. Thus, these data provide a systematic basis to understand the molecular mechanisms underlying the analgesic activity of herbal drugs.

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Section: Discussionmentioning

confidence: 99%

An Investigation of the Molecular Mechanisms Underlying the Analgesic Effect of Jakyak‐Gamcho Decoction: A Network Pharmacology Study

Lee¹,

Kang

Park³

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…Baicalein and naringenin ameliorate diabetic nephropathy by mitigating renal oxidative stress, normalizing serum pro-inflammatory cytokines levels, improving structural changes in renal tissues, and reducing apoptosis [120][121][122][123]. Besides, naringenin might also ameliorate diabetic vascular dysfunction, diabetic neuropathy, and diabetic retinopathy [124][125][126].…”

Section: Flavonoidsmentioning

confidence: 99%

A Systematic Review of Orthosiphon stamineus Benth. in the Treatment of Diabetes and Its Complications

Wang

et al. 2022

Molecules

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(1) Background: Orthosiphon stamineus Benth. is a traditional medicine used in the treatment of diabetes and chronic renal failure in southern China, Malaysia, and Thailand. Diabetes is a chronic metabolic disease and the number of diabetic patients in the world is increasing. This review aimed to systematically review the effects of O. stamineus in the treatment of diabetes and its complications and the pharmacodynamic material basis. (2) Methods: This systematic review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), using the databases ScienceDirect, PubMed, and Web of Science. (3) Results: Thirty-one articles related to O. stamineus and diabetes were included. The mechanisms of O. stamineus in the treatment of diabetes and its complications mainly included inhibiting α-amylase and α-glucosidase activities, antioxidant and anti-inflammatory activities, regulating lipid metabolism, promoting insulin secretion, ameliorating insulin resistance, increasing glucose uptake, promoting glycolysis, inhibiting gluconeogenesis, promoting glucagon-likepeptide-1 (GLP-1) secretion and antiglycation activity. Phenolic acids, flavonoids and triterpenoids might be the main components for hypoglycemia effects in O. stamineus. (4) Conclusion: O. stamineus could be an antidiabetic agent to treat diabetes and its complications. However, it needs further study on a pharmacodynamic substance basis and the mechanisms of effective constituents.

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“…Besides, there was currently no effective treatment to control oxaliplatin-induced NP optimally. Previous reports indicated that flavonoids could prevent the occurrence and development of chemotherapy-induced NP via suppressing apoptosis, oxidative stress, astrocyte and microglial activation, and inflammatory responses (Zhang Singh et al 2020;Xie et al 2020;Siddiqui et al 2021). Therefore, flavonoids may be a novel analgesic drug in the prevention and treatment of chemotherapy-induced NP.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the key targets and pharmacological mechanisms of rhamnocitrin against oxaliplatin-induced neuropathic pain based on network pharmacology approach and experimental validation

Cai¹,

Xu²

2022

gpb

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Naringenin ameliorates diabetic neuropathic pain by modulation of oxidative-nitrosative stress, cytokines and MMP-9 levels

Abstract: Diabetes mellitus is a serious debilitating epidemic affecting all social strata, imposing huge health, social and economic burdens.

Cited by 37 publications

References 53 publications

An Investigation of the Molecular Mechanisms Underlying the Analgesic Effect of Jakyak‐Gamcho Decoction: A Network Pharmacology Study

An Investigation of the Molecular Mechanisms Underlying the Analgesic Effect of Jakyak‐Gamcho Decoction: A Network Pharmacology Study

A Systematic Review of Orthosiphon stamineus Benth. in the Treatment of Diabetes and Its Complications

Investigation of the key targets and pharmacological mechanisms of rhamnocitrin against oxaliplatin-induced neuropathic pain based on network pharmacology approach and experimental validation

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