2020
DOI: 10.1016/j.ejphar.2020.173535
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Naringenin and naringin in cardiovascular disease prevention: A preclinical review

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Cited by 140 publications
(76 citation statements)
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“…The major compound detected on the GC-MS was naringenin, a flavanone, which has received considerable attention regarding its pharmacodynamic activities [39,40]. These include: antioxidant activity, through the increase of antioxidant enzymes [41]; anti-inflammatory activity [42]; anticancer activity, namely by the suppressive effect on TGF-β signaling pathway, and so cytotoxic effect in many cell lines, such as colon, pancreas, leukemia, stomach, liver and breast [43,44]; anti-diabetic activity [45]; and effects on central nervous system and on cardiovascular system [46][47][48][49][50]. According to the literature, naringenin is a flavonoid compound present in elderflower extracts.…”
Section: Chemical Composition Of S Nigra Extractmentioning
confidence: 99%
“…The major compound detected on the GC-MS was naringenin, a flavanone, which has received considerable attention regarding its pharmacodynamic activities [39,40]. These include: antioxidant activity, through the increase of antioxidant enzymes [41]; anti-inflammatory activity [42]; anticancer activity, namely by the suppressive effect on TGF-β signaling pathway, and so cytotoxic effect in many cell lines, such as colon, pancreas, leukemia, stomach, liver and breast [43,44]; anti-diabetic activity [45]; and effects on central nervous system and on cardiovascular system [46][47][48][49][50]. According to the literature, naringenin is a flavonoid compound present in elderflower extracts.…”
Section: Chemical Composition Of S Nigra Extractmentioning
confidence: 99%
“…[37][38][39][40] Moreover, naringenin could protect the recovery of ischemia/reperfusion (I/R) injury by inhibiting atherosclerotic and could improve the cardiac function and structure in the diabetic mice model. 41 Based on above biochemical and pharmacological characteristics of naringenin, it is possible to have a co-administration of naringenin with rivaroxaban in clinic, especially for the treatment of cardiovascular disease. Therefore, investigating the DDIs between naringenin and rivaroxaban might have significant theoretical and clinical application value.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, naringin has great potential for the treatment of cardiovascular disease because many in vitro studies and in vivo animal models have demonstrated that naringenin played an active role in the inhibition of atherosclerotic 37–40 . Moreover, naringenin could protect the recovery of ischemia/reperfusion (I/R) injury by inhibiting atherosclerotic and could improve the cardiac function and structure in the diabetic mice model 41 . Based on above biochemical and pharmacological characteristics of naringenin, it is possible to have a co‐administration of naringenin with rivaroxaban in clinic, especially for the treatment of cardiovascular disease.…”
Section: Discussionmentioning
confidence: 99%
“…It has anti-inflammatory, antioxidant, and antiapoptotic properties; it can regulate both autophagy and gluconeogenesis [ 97 ]. In addition, NRG can regulate molecular targets such as HMG-CoA reductase, NF- κ B, AMPK, Nrf2, and ROS [ 98 ]. NRG exhibits anti-bone resorption and antifat effects, enhances bone features, improves the bone microenvironment, and helps reconstruct bone structure [ 99 ].…”
Section: Natural Pharmacological Productsmentioning
confidence: 99%