Naringenin attenuates cell viability and migration of C6 glioblastoma cell line: a possible role of hedgehog signaling pathway

Sargazi, Marzieh Lotfian; Juybari, Kobra Bahrampour; Tarzi, Mojdeh Esmaeili; Amirkhosravi, Arian; Nematollahi, Mohammad Hadi; Mirzamohammdi, Solmaz; Mehrbani, Mehrzad; Mehrabani, Mehrnaz; Mehrabani, Mitra

doi:10.1007/s11033-021-06641-1

Cited by 34 publications

(14 citation statements)

References 35 publications

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“…Although hedgehog signaling is implicated in cancer and viral infections, its exact role in glioma remains unclear. A recent in vitro study showed that naringenin could attenuate glioblastoma cell viability and migration by suppressing the hedgehog signaling pathway ( Sargazi et al, 2021 ); however, to date, no in vivo studies have been carried out. Therefore, it would be beneficial to investigate the role of these new targets in the treatment of gliomas in preclinical and clinical studies.…”

Section: Discussionmentioning

confidence: 99%

m6A Regulatory Gene-Mediated Methylation Modification in Glioma Survival Prediction

Zhang

Zheng

et al. 2022

Front. Genet.

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The median survival of patients with gliomas is relatively short. To investigate the epigenetic mechanisms associated with poor survival, we analyzed publicly available datasets from patients with glioma. This analysis revealed 12 prognosis-related m6A regulatory genes that may be responsible for poor prognosis. These genes may be involved in genomic changes inherent to oxidative phosphorylation, adipogenesis, hedgehog signaling, and Myc signaling. We reconstructed a risk model with univariate and multivariate Cox analyses and identified older age and the m6A risk score as independent risk factors for predicting the prognosis of glioma patients, which is associated with glioma immune infiltration. In conclusion, m6A regulatory genes may serve as both reliable biomarkers and potential targets to increase the chance of survival of patients with glioma.

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Section: Discussionmentioning

confidence: 99%

m6A Regulatory Gene-Mediated Methylation Modification in Glioma Survival Prediction

Zhang

Zheng

et al. 2022

Front. Genet.

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“…When naringenin was combined with TMZ, there was a greater increase in the levels of caspase-8 and caspase-3, while the levels of Bcl-2 were downregulated [ 90 , 91 ]. Other than that, naringenin also decreased the expression of Gli-1 and Smo and upregulated the expression of Sufu to prevent proliferation and metastasis in C6 cells [ 92 ].…”

Section: Flavonoids and The Mechanism Of Action Against High-grade Ad...mentioning

confidence: 99%

Anticancer Mechanism of Flavonoids on High-Grade Adult-Type Diffuse Gliomas

2023

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High-grade adult-type diffuse gliomas are the most common and deadliest malignant adult tumors of the central nervous system. Despite the advancements in the multimodality treatment of high-grade adult-type diffuse gliomas, the five-year survival rates still remain poor. The biggest challenge in treating high-grade adult-type diffuse gliomas is the intra-tumor heterogeneity feature of the glioma tumors. Introducing dietary flavonoids to the current high-grade adult-type diffuse glioma treatment strategies is crucial to overcome this challenge, as flavonoids can target several molecular targets. This review discusses the anticancer mechanism of flavonoids (quercetin, rutin, chrysin, apigenin, naringenin, silibinin, EGCG, genistein, biochanin A and C3G) through targeting molecules associated with high-grade adult-type diffuse glioma cell proliferation, apoptosis, oxidative stress, cell cycle arrest, migration, invasion, autophagy and DNA repair. In addition, the common molecules targeted by the flavonoids such as Bax, Bcl-2, MMP-2, MMP-9, caspase-8, caspase-3, p53, p38, Erk, JNK, p38, beclin-1 and LC3B were also discussed. Moreover, the clinical relevance of flavonoid molecular targets in high-grade adult-type diffuse gliomas is discussed with comparison to small molecules inhibitors: ralimetinib, AMG232, marimastat, hydroxychloroquine and chloroquine. Despite the positive pre-clinical results, further investigations in clinical studies are warranted to substantiate the efficacy and safety of the use of flavonoids on high-grade adult-type diffuse glioma patients.

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“…The chemical activities of 5-pentylresorcinol were investigated against these enzymes. As the chemical and natural compounds have potential anti-cancer activities 24,25) , the anti-cancer activity of 5-pentylresorcinol was assessed against breast cancer by investigation of the compound s activity against the BRCT repeat region from the breast cancer-associated protein (BRCA1) ( PDB ID: 1JNX) . The structures of the enzymes and protein were downloaded from the PDB database (http://www.rcsb.org/pdb) , prepared by performing the protein preparation module of the Schrödinger Suite 26) .…”

Section: Molecular Docking Studymentioning

confidence: 99%

Anti-breast Adenocarcinoma and Anti-urease Anti-tyrosinase Properties of 5-Pentylresorcinol as Natural Compound with Molecular Docking Studies

Yang

Zhao

et al. 2022

J. Oleo Sci.

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IntroductionNatural compounds play a significant role in cancer treatment with substantial numbers of anticancer factors utilized in the clinic being either derived or natural from important products from various sources like animals, plants, and microorganisms 1) . 5-Pentylresorcinol (Fig. 1) compound is a naturally happening organic molecule. It is recorded in particular species of lichens that can be readily extracted, also, it is also a precursor in various syntheses of tetrahydrocannabinol. This compound was used as a template molecule in the synthesis of molecularly imprinted polymer. It was also used as an inhibitor of (S) -mephenytoin 4′ -hydroxylase activity of recombinant CYP2C19 2) . Additionally, it is also produced by several insects, either # means Xiaopeng Yang and Zhenyu Zhao have contributed equally to this work.

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Naringenin attenuates cell viability and migration of C6 glioblastoma cell line: a possible role of hedgehog signaling pathway

Cited by 34 publications

References 35 publications

m6A Regulatory Gene-Mediated Methylation Modification in Glioma Survival Prediction

m6A Regulatory Gene-Mediated Methylation Modification in Glioma Survival Prediction

Anticancer Mechanism of Flavonoids on High-Grade Adult-Type Diffuse Gliomas

Anti-breast Adenocarcinoma and Anti-urease Anti-tyrosinase Properties of 5-Pentylresorcinol as Natural Compound with Molecular Docking Studies

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