Naringenin attenuates cisplatin nephrotoxicity in rats

Nephroprotective activity ofMacrothelypteris oligophlebiarhizomes ethanol extract

“…These six known flavonoids obtained from EMO were isolated for the first time from this plant. Naringenin and protoapigenone have been shown to possess antioxidant, nephroprotective, neuroprotective and antitumor activities (Badary et al, 2005;Youdim & Bakhle, 2006;Huang et al, 2010). In this study, the nephroprotective activity of ethanol extract of M. oligophlebia rhizomes was evaluated for the first time.…”

“…The decreased SOD activity is not enough to scavenge the superoxide anion produced during the normal metabolic process and cause the initiation and propagation of lipid peroxidation in GM-treated group (Nitha & Janardhanan, 2008). The activities of CAT and GSH-Px also decreased in the GM-treated group, which resulted in the decreased ability of renal to scavenge toxic hydrogen peroxide and lipid peroxidation (Badary et al, 2005;Nitha & Janardhanan, 2008). Therefore, the significant increase in the level of MDA, as marker of lipid peroxidation, was observed in the GM-treated group.…”

Cisplatin-induced nephrotoxicity and targets of nephroprotection: an update

“…Experimental studies have reported the protective effects of natural compounds such as vitamins C (Tarladacalisir et al 2008), E (Ajith et al 2009), and A (Dillioglugil et al 2005); resveratrol (Do Amaral et al 2008), quercetin (Francescato et al 2004), and caffeic acid phenethyl ester (Ozen et al 2004); naringenin (Badary et al 2005) and lycopene (Atessahin et al 2005), as well as synthetic compounds such as DMTU (Santos et al 2008), DMSO (Jones et al 1991), carvedilol (Rodrigues et al 2010), allopurinol plus ebselem (Lynch et al 2005), edaravone (Satoh et al 2003;Iguchi et al 2004), desferrioxamine (DFO) (Kadikoylu et al 2004), and many others. Antioxidants protect kidneys from cisplatin damage mainly by free radical scavenging or iron chelation (Koyner et al 2008).…”

Ameliorative effect ofApodytes dimidiataon cisplatin-induced nephrotoxicity in Wistar rats

“…However, the clinical usefulness of this drug is limited due to its side effects including nephrotoxicity. When cisplatin accumulates in renal epithelial cells, the GSH concentration and antioxidant enzymes activities become depleted which eventually leads to the hike in intracellular concentrations of ROS (Badary et al 2005). Cisplatin also enhances Ca ++ independent nitric oxide synthase activity leading to the increased production of nitric oxide (Srivastava et al 1996).…”