Naringin ameliorates pentylenetetrazol-induced seizures and associated oxidative stress, inflammation, and cognitive impairment in rats: Possible mechanisms of neuroprotection

Golechha, Mahaveer; Sarangal, Vikas; Bhatia, Jagriti; Chaudhry, Uma; Saluja, Daman; Arya, Dharamvir Singh

doi:10.1016/j.yebeh.2014.09.058

Cited by 60 publications

(31 citation statements)

References 34 publications

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“…The present results showed that naringin attenuates NF-κB p65 unit, TNF-α, IL-1β and IL-6 activity in AS mice. These results are consistent with a previous study in which naringin was shown to ameliorate oxidative stress and inflammation in mice (28). In addition, it has been suggested that naringin may exert anti-inflammatory effects in the adult brain (29).…”

Section: A B a Bsupporting

confidence: 93%

Protective effect of naringin against ankylosing spondylitis via ossification, inflammation and oxidative stress in mice

Liu

Shi

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Naringin is an abundant flavanone in pomelo, grapefruit as well as lime and its variants, has been shown to exhibit certain antioxidative, anti-inflammatory, anti-cancer and hypoglycemic effects. The aim of the current study was to evaluate the protective effects of naringin against ankylosing spondylitis (AS) and to elucidate the potential underlying mechanism. Firstly, a mouse model of ankylosing spondylitis (AS) was established. Next, osteocalcin (OC), alkaline phosphatase (ALP) and triglyceride (TG) activity values, inflammatory factor and oxidative stress were evaluated in the AS mice. Then, the Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) protein expression levels in the AS mice were investigated using western blot analysis. The results showed that naringin increased OC, ALP and TG activity values in the AS mouse model. Furthermore, inflammatory factor and oxidative stress levels in the AS mice were restrained by treatment with naringin. Furthermore, JAK2 and STAT3 protein expression levels were reduced by treatment with naringin. In conclusion, the present results indicated that the protective effects of naringin against AS are exerted via the induction of ossification, suppression of inflammation and oxidative stress and the downregulation of JAK2/STAT3 in mice.

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Section: A B a Bsupporting

confidence: 93%

Protective effect of naringin against ankylosing spondylitis via ossification, inflammation and oxidative stress in mice

Liu

Shi

et al. 2016

Experimental and Therapeutic Medicine

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“…In pentylenetetrazole-induced seizure rats, naringin reduces oxidative stress by binding free radicals and regulating the GSH level. Pretreatment with naringin for several hours has been shown to significantly attenuate pentylenetetrazole-induced elevations in the brain malondialdehyde and TNF-a level and to conserve GSH (Golechha et al 2014). In diabetic rats, naringinreduced diabetes-induced lipid peroxidation and ROS accumulation in sperm and curbed the reduction in the GSH:oxidized GSH ratio (Bakheet & Attia 2011).…”

Section: Effects On Oxidative Stressmentioning

confidence: 99%

Therapeutic potential of naringin: an overview

Chen

Wang

et al. 2016

Pharmaceutical Biology

313

166

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Context: Naringin is a natural flavanone glycoside that is found in the Chinese herbal medicines and citrus fruits. Studies have demonstrated that naringin possesses numerous biological and pharmacological properties, but few reviews of these studies have been performed. Objective: The present review gathers the fragmented information available in the literature describing the extraction of naringin, its pharmacology and its controlled release formulations. Current research progress and the therapeutic potential of naringin are also discussed. Methods: A literature survey for relevant information regarding the biological and pharmacological properties of naringin was conducted using Pubmed, Sciencedirect, MEDLINE, Springerlink and Google Scholar electronic databases from the year 2007-2015. Results: Naringin modulates signalling pathways and interacts with signalling molecules and thus has a wide range of pharmacological activities, including anti-inflammatory, anti-cancer activities, as well as effects on bone regeneration, metabolic syndrome, oxidative stress, genetic damage and central nervous system (CNS) diseases. Information was gathered that showed the extraction of naringin can be improved using several modifications. There has been some progress in the development of controlled release formulations of naringin. Conclusion: Naringin is a promising candidate for further in vivo studies and clinical use. More detailed studies regarding its mechanism of action are required. ARTICLE HISTORY

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“…Recent studies have suggested that the flavonoids exhibit protection against neurodegeneration [19,20]. Naringin, a well-known flavanone glycoside of grape fruits, e.g., Citrus paradise, Citrus unshiu, and Citrus sinensis, has been reported to attenuate the oxidative stress, apoptosis, and inflammation, demonstrated to possess neuroprotective effect [21,22]. Further, naringin has been reported to possess various biological and pharmacological properties including antioxidant, anti-carcinogenic, and anti-atherogenic properties [23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective efficacy of naringin on 3-nitropropionic acid-induced mitochondrial dysfunction through the modulation of Nrf2 signaling pathway in PC12 cells

Gopinath

Sudhandiran

2015

Mol Cell Biochem

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Naringin ameliorates pentylenetetrazol-induced seizures and associated oxidative stress, inflammation, and cognitive impairment in rats: Possible mechanisms of neuroprotection

Cited by 60 publications

References 34 publications

Protective effect of naringin against ankylosing spondylitis via ossification, inflammation and oxidative stress in mice

Protective effect of naringin against ankylosing spondylitis via ossification, inflammation and oxidative stress in mice

Therapeutic potential of naringin: an overview

Neuroprotective efficacy of naringin on 3-nitropropionic acid-induced mitochondrial dysfunction through the modulation of Nrf2 signaling pathway in PC12 cells

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