Neuroprotective efficacy of naringin on 3-nitropropionic acid-induced mitochondrial dysfunction through the modulation of Nrf2 signaling pathway in PC12 cells

Gopinath, Kulasekaran; Sudhandiran, Ganapasam

doi:10.1007/s11010-015-2525-9

Cited by 58 publications

(34 citation statements)

References 69 publications

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“…The presence of naringin may have triggered the activation Nrf2 signalling pathway reducing the DOX induced oxidative stress. 80 …”

Section: Discussionmentioning

confidence: 99%

Treatment of Mice with Naringin Alleviates the Doxorubicin-Induced Oxidative Stress in the Liver of Swiss Albino Mice

Ch¹,

Jagetia²,

Lalrinengi³

2017

MOJAP

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Doxorubicin a photosensitive antibiotic is frequently used to treat various malignancies in clinics; however, doxorubicin is also taken up by the normal cells of the body leading to increased oxidative stress and subsequently DNA damage and dysfunction in the cells. The agents which can reduce the adverse effect of doxorubicin will of great value. The present study has attempted to study the effect of naringin a citrus flavonoid on the doxorubicininduced oxidative stress in mice liver. The mice were administered with 0, 1, 5 or 10mg/ kg body weight of doxorubicin and treated with 10mg/kg body weight of naringin before or after doxorubicin treatment. The glutathione concentration and lipid peroxidation and activities of glutathione-s-transferase, catalase and super oxide dismutase were studied at 0.5, 1, 2 and 4h post-treatment in the mouse liver. The doxorubicin increased the lipid peroxidation in a dose dependent manner at all the post treatment times. Conversely, it attenuated the activities of glutathione-s-transferase, catalase and super oxide dismutase in dose dependent fashion and time dependent manner. A similar effect was observed for glutathione concentration. Treatment of mice with naringin before or after doxorubicin treatment elevated all the antioxidants and reduced the doxorubicin -induced lipid peroxidation. The effect of naringin pretreatment was more effective when compared to its post treatment. The naringin was very effective in reducing the oxidative stress induced by doxorubicin as indicated by the elevated levels of glutathione concentration, glutathiones-transferase, catalase and super oxide dismutase. The pretreatment of naringin was better than its post treatment.

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“…The presence of naringin may have triggered the activation Nrf2 signalling pathway reducing the DOX induced oxidative stress. 80 …”

Section: Discussionmentioning

confidence: 99%

Treatment of Mice with Naringin Alleviates the Doxorubicin-Induced Oxidative Stress in the Liver of Swiss Albino Mice

Ch¹,

Jagetia²,

Lalrinengi³

2017

MOJAP

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“…Naringin ameliorates cognitive deficits via oxidative stress, proinflammatory factors and the PPARγ signaling pathway in a type 2 diabetic rat model (Qi et al 2015). Naringin protects neural cells on 3-nitropropionic acid-induced mitochondrial dysfunction through modulation of Nrf2 signaling pathway (Kulasekaran and Ganapasam 2015). Naringin induces autophagy-mediated growth inhibition by downregulating the PI3K/Akt/mTOR cascade via activation of MAPK pathways in AGS cancer cells (Raha et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Naringin, a natural dietary compound, prevents intestinal tumorigenesis in Apc Min/+ mouse model

Zhang

Wang

et al. 2015

J Cancer Res Clin Oncol

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“…The PC12 cell line is a widely used experimental model for neuroprotection and neurodegeneration analysis, particularly in the contexts of excitotoxicity [30,31], whereas 3-nitropropionic acid is usually applied as a neurotoxic agent trigger for mitochondrial dysfunction [13]. We used both in our in vitro study for the examination of the potential protective action of the ethanolic extract of A. asphodeloides against neurotoxic agents.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, 3-NP is a specific inhibitor of the mitochondrial complex II electron transport chain, so it consequently leads to an excessive ROS production, mitochondrial DNA damage, and loss of the physiological function of mitochondria. Hence, 3-NP induces cell death, via necrosis or apoptosis, especially these in the nervous system [13,14]. Some in vivo research has indicated that 3-NP acts on cortical activity, but its overall effect is complex, involving elements of depression and excitation, which is important in neurodegenerative pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

Anemarrhenae asphodeloides rhizoma Extract Enriched in Mangiferin Protects PC12 Cells against a Neurotoxic Agent-3-Nitropropionic Acid

Piwowar

Rembiałkowska

Rorbach-Dolata

et al. 2020

IJMS

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The rhizome of Anemarrhena asphodeloides Bunge, used in Traditional Chinese Medicine as a brain function-improving herb, is a promising source of neuroprotective substances. The aim of this study was to evaluate the protective action of xanthones from A. asphodeloides rhizomes on the PC12 cell line exposed to the neurotoxic agent—3-nitropropionic acid (3-NP). The xanthone-enriched fraction of the ethanolic extract of A. asphodeloides (abbreviated from now on as XF, for the Xanthone Fraction), rich in polyphenolic xanthone glycosides, in concentrations from 5 to 100 μg/mL, and 3-NP in concentrations from 2.5 to 15 mM, were examined. After 8, 16, 24, 48, and 72 h of exposure of cells to various combinations of 3-NP and XF, the MTT viability assay was performed and morphological changes were estimated by confocal fluorescence microscopy. The obtained results showed a significant increase in the number of cells surviving after treatment with XF with exposure to neurotoxic 3-NP and decreased morphological changes in PC12 cells in a dose and time dependent manner. The most effective protective action was observed when PC12 cells were pre-incubated with the XF. This effect may contribute to the traditional indications of this herb for neurological and cognitive complaints. However, a significant cytotoxicity observed at higher XF concentrations (over 10 µg/mL) and longer incubation time (48 h) requires caution in future research and thorough investigation into potential adverse effects.

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Neuroprotective efficacy of naringin on 3-nitropropionic acid-induced mitochondrial dysfunction through the modulation of Nrf2 signaling pathway in PC12 cells

Cited by 58 publications

References 69 publications

Treatment of Mice with Naringin Alleviates the Doxorubicin-Induced Oxidative Stress in the Liver of Swiss Albino Mice

Treatment of Mice with Naringin Alleviates the Doxorubicin-Induced Oxidative Stress in the Liver of Swiss Albino Mice

Naringin, a natural dietary compound, prevents intestinal tumorigenesis in Apc Min/+ mouse model

Anemarrhenae asphodeloides rhizoma Extract Enriched in Mangiferin Protects PC12 Cells against a Neurotoxic Agent-3-Nitropropionic Acid

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