Naringin: Nanotechnological Strategies for Potential Pharmaceutical Applications

Ravetti, Soledad; Garro, Ariel G.; Gaitán, Agustina; Murature, Mariano; Galiano, Mariela; Brignone, Sofía Gisella; Palma, Santiago Daniel

doi:10.3390/pharmaceutics15030863

Cited by 25 publications

(9 citation statements)

References 90 publications

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“… Flavanones , especially naringenin and hesperidin, are inserted into TP with an anti-inflammatory purpose. They are used for atopic dermatitis, WD nanoemulsions or nanogels on different polymeric supports, or lipidic nanocarriers [ 186 , 187 , 188 ]. Flavones represented by apigenin, which is a hydrophobic flavone, have been used in several formulations so far for TD, including liposomes, nanocrystal gel formulations, and self-micro-emulsifying delivery systems for anti-inflammatory and breast cancer treatment [ 189 , 190 ].…”

Section: Natural Products From Plants Used In Medical Devicesmentioning

confidence: 99%

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From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

Isopencu,

Covaliu-Mierlă,

Deleanu

2023

Plants

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Transdermal delivery devices and wound dressing materials are constantly improved and upgraded with the aim of enhancing their beneficial effects, biocompatibility, biodegradability, and cost effectiveness. Therefore, researchers in the field have shown an increasing interest in using natural compounds as constituents for such systems. Plants, as an important source of so-called “natural products” with an enormous variety and structural diversity that still exceeds the capacity of present-day sciences to define or even discover them, have been part of medicine since ancient times. However, their benefits are just at the beginning of being fully exploited in modern dermal and transdermal delivery systems. Thus, plant-based primary compounds, with or without biological activity, contained in gums and mucilages, traditionally used as gelling and texturing agents in the food industry, are now being explored as valuable and cost-effective natural components in the biomedical field. Their biodegradability, biocompatibility, and non-toxicity compensate for local availability and compositional variations. Also, secondary metabolites, classified based on their chemical structure, are being intensively investigated for their wide pharmacological and toxicological effects. Their impact on medicine is highlighted in detail through the most recent reported studies. Innovative isolation and purification techniques, new drug delivery devices and systems, and advanced evaluation procedures are presented.

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Section: Natural Products From Plants Used In Medical Devicesmentioning

confidence: 99%

Section: Natural Products From Plants Used In Medical Devicesmentioning

confidence: 99%

From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

Isopencu,

Covaliu-Mierlă,

Deleanu

2023

Plants

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“…We previously found that Si-Ni-San, a traditional Chinese medicine formula, was capable of promoting estrogen metabolism in the liver, and naringenin (NAR) has been identified as a potential bioactive compound targeting EST [ 23 ]. However, the poor solubility and bioavailability of NAR limits its efficacy [ 24 ]. In the past decades, nanoparticle-based drug delivery systems have emerged as a powerful tool for cancer therapy, such as photothermal therapy [ 25 ], sonodynamics [ 26 , 27 ], and redox targeting strategies [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Developing liver-targeted naringenin nanoparticles for breast cancer endocrine therapy by promoting estrogen metabolism

Zhao,

Tan,

Zhang

et al. 2024

J Nanobiotechnol

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Endocrine therapy is standard for hormone receptor–positive (HR+) breast cancer treatment. However, current strategies targeting estrogen signaling pay little attention to estradiol metabolism in the liver and is usually challenged by treatment failure. In a previous study, we demonstrated that the natural compound naringenin (NAR) inhibited HR+ breast cancer growth by activating estrogen sulfotransferase (EST) expression in the liver. Nevertheless, the poor water solubility, low bio-barrier permeability, and non-specific distribution limited its clinical application, particularly for oral administration. Here, a novel nano endocrine drug NAR-cell penetrating peptide-galactose nanoparticles (NCG) is reported. We demonstrated that NCG presented specific liver targeting and increased intestinal barrier permeability in both cell and zebrafish xenotransplantation models. Furthermore, NCG showed liver targeting and enterohepatic circulation in mouse breast cancer xenografts following oral administration. Notably, the cancer inhibition efficacy of NCG was superior to that of both NAR and the positive control tamoxifen, and was accompanied by increased hepatic EST expression and reduced estradiol levels in the liver, blood, and tumor tissue. Moreover, few side effects were observed after NCG treatment. Our findings reveal NCG as a promising candidate for endocrine therapy and highlight hepatic EST targeting as a novel therapeutic strategy for HR+ breast cancer. Graphical Abstract

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“…Icariin shows promising characteristics in biomedicine and bone/cartilage tissue engineering [10]. Naringin (4 , 5,7-trihydroxy flavanone-7-rhamnoglucoside, Figure 1) is a flavonoid glycoside that is found in the extract of citrus fruits [11] and rhizoma drynariae [12]. Naringin possesses several pharmacological effects, including anti-inflammation, anti-oxidation, anti-cancer, anti-bacteria, liver protection, and bone/cartilage protection [13,14].…”

Section: Introductionmentioning

confidence: 99%

The Development of Naringin for Use against Bone and Cartilage Disorders

Gan

Deng

et al. 2023

Molecules

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Bone and cartilage disorders are the leading causes of musculoskeletal disability. There is no absolute cure for all bone and cartilage disorders. The exploration of natural compounds for the potential therapeutic use against bone and cartilage disorders is proving promising. Among these natural chemicals, naringin, a flavanone glycoside, is a potential candidate due to its multifaceted pharmacological activities in bone and cartilage tissues. Emerging studies indicate that naringin may promote osteogenic differentiation, inhibit osteoclast formation, and exhibit protective effects against osteoporosis in vivo and in vitro. Many signaling pathways, such as BMP-2, Wnt/β-catenin, and VEGF/VEGFR, participate in the biological actions of naringin in mediating the pathological development of osteoporosis. In addition, the anti-inflammatory, anti-oxidative stress, and anti-apoptosis abilities of naringin also demonstrate its beneficial effects against bone and cartilage disorders, including intervertebral disc degeneration, osteoarthritis, rheumatoid arthritis, bone and cartilage tumors, and tibial dyschondroplasia. Naringin exhibits protective effects against bone and cartilage disorders. However, more efforts are still needed due to, at least in part, the uncertainty of drug targets. Further biological and pharmacological evaluations of naringin and its applications in bone tissue engineering, particularly its therapeutic effects against osteoporosis, might result in developing potential drug candidates.

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Naringin: Nanotechnological Strategies for Potential Pharmaceutical Applications

Cited by 25 publications

References 90 publications

From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

Developing liver-targeted naringenin nanoparticles for breast cancer endocrine therapy by promoting estrogen metabolism

The Development of Naringin for Use against Bone and Cartilage Disorders

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