Naringin sensitizes human prostate cancer cells to paclitaxel therapy

Erdoğan, Suat; Doğanlar, Oğuzhan; Doğanlar, Zeynep Banu; Turkekul, Kader

doi:10.1016/j.prnil.2017.11.001

Cited by 59 publications

(32 citation statements)

References 33 publications

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“…Our results proved that naringin repressed the development of the endothelial HUVEC cells in a concentration-dependent manner with a lesser IC50ccompared with that raised on U87 glioma cells. Such IC50 was already reported for naringin with other cancers such as osteosarcoma [17], prostate cancer [18], intestinal cancer [19] and glioma [20] suggesting that extended surgery with naringin could be possibly advantageous strategy for gliomas prevention and treatment.…”

Section: Discussionmentioning

confidence: 56%

Natural dietary compound naringin inhibits glioblastoma cancer neoangiogenesis

Aroui

Fetoui

Kénani

2020

BMC Pharmacol Toxicol

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Background: Flavonoids, which existed nearly in all fruits and vegetables, are considered as a class of plantsecondary metabolites with a polyphenolic structure and have properties with health-improving potential. Yet, not so many experimental focus on the benefits of flavonoid in vivo after external application. Here we assessed the impacts of naringin in vitro and in vivo in the human glioma U-87 cells implanted into athymic mice. Methods: Tumor size and animal survival time were followed in naringin-treated mice bearing subcutaneous gliomas. To define the effects of naringin on angiogenesis, in vitro, tube formation and migration were assayed using endothelial HUVEC cell line. Results: Low concentration of naringin remarkably inhibited tubulogenesis and reduced cell invasion. Moreover, naringin has been shown to have a toxicity effect on U-87 cells in a dose-dependent way. Furthermore, naringin administration (120 mg/kg/day) applies serious anti-cancer belongings on glioblastoma, as demonstrated by a slow cancer progression. Conclusions: Our study has provided the first evidence on the antitumor effect of naringin, which is somehow due to the inhibition of invasion and angiogenesis.

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Section: Discussionmentioning

confidence: 56%

Natural dietary compound naringin inhibits glioblastoma cancer neoangiogenesis

Aroui

Fetoui

Kénani

2020

BMC Pharmacol Toxicol

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“…According to a recent research, naringin inhibits cell viability and induces apoptosis in PC-3, LNCaP, and DU145 cells. Furthermore, naringin synergistically increases the effect of paclitaxel in the treatment of prostate cancer cells [49]. Korean Angelica gigas…”

Section: Discussionmentioning

confidence: 98%

HMT Inhibits Prostate Cancer Progression by Targeting PAK-1.

Lee¹,

Xu²,

Lee³

et al. 2020

Preprint

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Background: Heamatang (HMT) is a classic medicinal formula used in traditional Chinese and Korean medicine; it contains seven distinct components, mainly of herbal origin. HMT is used as an anti-aging remedy, in the treatment of urinary disorders, and to increase energy and vitality. However, the therapeutic applications of this formula have not been evaluated with evidence-based science. Methods: Therefore, we assessed HMT through various in vitro methods, including cell viability assay, fluorescence-activated cell sorting assay (FACS), western blotting, migration assay, three-dimensional (3D) cell culture, siRNA-mediated PAK-1 knockdown, and crystal violet assays. Results: HMT decreased PAK-1 expression in PC-3 cells and inhibited cell viability, growth, and motility. The inhibition of cell motility by HMT was correlated with PAK-1-mediated inhibition of Lim domain kinase (LIMK) and cofilin. HMT induced G1 arrest and apoptosis through the transcriptional regulation of cell cycle regulatory proteins (inhibition of cyclin-dependent kinase (CDK) 4, 6, and cyclin D1) and apoptosis-related proteins (increase in cleaved caspase-3 (c-cas3) and inhibition of poly ADP-ribose polymerase (PARP) and B-cell lymphoma 2 (BCL-2)). Moreover, HMT suppressed P21-activated kinase (PAK-1) expression, leading to the inhibition of AKT activities. Finally, we showed that Decursin was the active ingredient involved in the inhibitory effect of HMT on PAK-1. Conclusion: Our findings demonstrated that HMT exerts its anticancer influence through the inhibition of PAK-1 expression. The HMT formula could be applied in various fields, including functional health food and pharmaceutical development.

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“…Loss of PTEN expression leads to the activation of AKT and PI3K, which in turn promotes β-catenin phosphorylation and the malignant proliferation of cancer cells, which is common in cases of CRC (36)(37)(38). However, naringin can inhibit this reaction to some extent (39).…”

Section: Discussionmentioning

confidence: 99%

Naringin inhibits colorectal cancer cell growth by repressing the PI3K/AKT/mTOR signaling pathway

et al. 2020

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In recent years, the incidence of colorectal cancer (CRC) has increased and research into new treatment methods for CRC has become a hot topic. Naringin has an inhibitory effect on the PI3k/AKT/mTOR signaling pathway in various tumor cell types and the effect of naringin is closely related to the occurrence and proliferation of tumor cells. The aim of this present study was to investigate whether naringin could inhibit the proliferation of CRC cells by inhibiting the PI3K/AKT/mTOR signaling pathway. This could provide a more mechanism-based treatment for CRC. MTT assays were used to detect the proliferation of CRC cells treated with various concentrations of naringin. The degree of apoptosis and the expression of apoptosis-related proteins (Bcl-2 and Bax) in CRC cells stimulated by naringin was detected using flow cytometry and western blot assays, respectively. The expression levels of PI3K/AKT/mTOR-related proteins [PI3K, AKT, mTOR, phosphorylated (p)-PI3K, p-AKT and p-mTOR] after naringin stimulation in CRC cells were detected using western blot assays. Naringin inhibited the proliferation of CRC cells in a dose-dependent manner. Naringin promoted the apoptosis of CRC cells and inhibited the activation of the PI3K/AKT/mTOR signaling pathway in a dose-dependent manner. The results demonstrated that naringin may be a promising therapeutic agent for the treatment of CRC, which may inhibit the proliferation of CRC cells and induce apoptosis by inhibiting the PI3K/AKT/mTOR signaling pathway.

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Naringin sensitizes human prostate cancer cells to paclitaxel therapy

Cited by 59 publications

References 33 publications

Natural dietary compound naringin inhibits glioblastoma cancer neoangiogenesis

Natural dietary compound naringin inhibits glioblastoma cancer neoangiogenesis

HMT Inhibits Prostate Cancer Progression by Targeting PAK-1.

Naringin inhibits colorectal cancer cell growth by repressing the PI3K/AKT/mTOR signaling pathway

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