Narkoseeinfl�sse auf akustisch evozierte Potentiale aus dem Colliculus inferior und dem auditiven Cortex beim Meerschweinchen

Dum, N.

doi:10.1007/bf00459912

Arch Otorhinolaryngol

1982

DOI: 10.1007/bf00459912

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Narkoseeinfl�sse auf akustisch evozierte Potentiale aus dem Colliculus inferior und dem auditiven Cortex beim Meerschweinchen

N. Dum

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1983

1991

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Cited by 4 publications

References 16 publications

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The influence of moderate-intensity noise on the click-evoked compound action potential of the guinea pig, Cavia porcellus

Walger

Schmidt

Wedel

1985

Arch Otorhinolaryngol

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Noise-induced alterations of the click-evoked compound potential (CAP) were studied by means of electrodes chronically implanted near the round window in 15 pigmented guinea pigs aged 3-6 months. The potentials were recorded before, during and after exposure to continuous pink noise maintained at an intensity of 80, 90 or 100 dB SPL for 120 h. During the exposure phase the CAP thresholds of all the animals tested increased exponentially, nearly leveling out by approximately 48 h to form an asymptotic threshold shift. Recovery after the end of exposure also occurred exponentially, with a return to the original threshold for neural excitation after at most 72 h. There was no detectable change in amplitude, latency or inter-peak interval of the CAP when correlated with the change in threshold.

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The influence of moderate-intensity noise on the click-evoked compound action potential of the guinea pig, Cavia porcellus

Walger

Schmidt

Wedel

1985

Arch Otorhinolaryngol

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Effects of age upon auditory evoked potentials from the inferior colliculus and cortex in the guinea pig

Dum

1983

Arch Otorhinolaryngol

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Auditory evoked potentials from the inferior colliculus and cortex were examined for evidence of the effect of aging in central regions of the auditory system of the guinea pig. The threshold was 25 dB higher in the responses from the inferior colliculus and 44 dB higher in the cortical potentials in old animals than in young animals. The latency of the collicular responses in the old group was greater by 1.5 ms and, in the high-frequency range, the amplitudes were smaller at all intensities tested. The latency of responses recorded from the auditory cortex in the old guinea pigs was 3.6 ms greater at threshold and the amplitudes were smaller. With stimuli well above threshold, the latency differences were no longer significant, whereas the amplitudes in old animals became significantly greater than those in the young.

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The value of fentanyl/diazepam anesthesia for experimental operations

Mertens

Müller-Deile

1991

Eur Arch Otorhinolaryngol

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Fentanyl/diazepam anesthesia is an appropriate combination for surgical operations on the guinea pig, since it ensures definitive anesthesia and analgesia without respiratory depression. Comparative investigations with pentobarbital and urethane were carried out to check their applicability for electrocochleographic recordings. We found that fentanyl/diazepam combination anesthesia is more suitable for electrocochleographic investigations than pentobarbital. We were thereby able to prove that pentobarbital has an attenuating effect on electrocochleographic recordings in contrast to the findings reported in the available literature. For this reason, and because the lowest rates of animal morbidity occurred with fentanyl/diazepam, this combination anesthesia should be used preferentially for electrophysiological experiments in guinea pigs.

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Narkoseeinfl�sse auf akustisch evozierte Potentiale aus dem Colliculus inferior und dem auditiven Cortex beim Meerschweinchen

Cited by 4 publications

References 16 publications

The influence of moderate-intensity noise on the click-evoked compound action potential of the guinea pig, Cavia porcellus

The influence of moderate-intensity noise on the click-evoked compound action potential of the guinea pig, Cavia porcellus

Effects of age upon auditory evoked potentials from the inferior colliculus and cortex in the guinea pig

The value of fentanyl/diazepam anesthesia for experimental operations

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