Narrative review on potential role of gut microbiota in certain substance addiction

Qin, Chenyuan; Hu, Jiawei; Wan, Yiming; Cai, Mengyao; Wang, Zhenting; Zhao, Peng; Liao, Yixiang; Li, Dan; Yao, Ping; Liu, Liegang; Rong, Shuang; Bao, Wei; Xu, Guoqing; Yang, Wei

doi:10.1016/j.pnpbp.2020.110093

Cited by 22 publications

(9 citation statements)

References 176 publications

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“…In recent years, there has been an increasing interest in the gut microbiota as a potential target for novel therapeutics, due to its tremendous impact on the brain, behavior, and health ( Cryan et al., 2019 ). While the majority of work concerning the role of the gut microbiota in neuropsychiatric conditions has focused on autism spectrum disorder ( Sharon et al., 2019 ; Wang et al., 2019 ), Alzheimer’s disease ( Vogt et al., 2017 ; Bulgart et al., 2020 ), Parkinson’s disease ( Petrov et al., 2017 ; Aho et al., 2019 ), depression ( Bastiaanssen et al., 2020 ; Yang et al., 2020 ), anxiety ( Jiang et al., 2018 ) and schizophrenia ( Zhu et al., 2019 ; Golofast and Vales, 2020 ), the evidence of interactions between the gut microbiota and substance use has been relatively limited ( Qin et al., 2021 ; Salavrakos et al., 2021 ), and even less is known in the context of METH use.…”

Section: Introductionmentioning

confidence: 99%

“…For MUD, the interaction between gut microbiota and the host immune system has been assumed to be one of the key mechanisms. It was hypothesized that METH-induced pro-inflammatory microbiota profile and gut barrier dysfunction might allow the translocation of bacteria and bacterial components into the circulation, thus exacerbate systemic inflammation, abnormal immune response and neuroinflammation, leading to aberrant brain function and behaviors ( Prakash et al., 2017 ; Qin et al., 2021 ), but no definitive evidence currently exists to prove this hypothesis. Indeed, studies have shown that METH elicits dysregulation in the innate and adaptive immune response, causing changes to both pro- and anti- inflammatory cytokines ( Papageorgiou et al., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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Altered Fecal Microbiota Correlated With Systemic Inflammation in Male Subjects With Methamphetamine Use Disorder

Deng

Song

et al. 2021

Front. Cell. Infect. Microbiol.

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Methamphetamine use disorder (MUD) is a major public health problem worldwide with limited effective treatment options. Previous studies have reported methamphetamine-associated alterations in gut microbiota. A potential role of gut microbiota in regulating methamphetamine-induced brain dysfunction through interactions with the host immune system has been proposed, but evidence for this hypothesis is limited. The present study aimed to investigate the alterations in the fecal microbiota and explore its relationship with systemic inflammation in MUD. Fecal samples were obtained from 26 male subjects with MUD and 17 sex- and age- matched healthy controls. Fecal microbial profiles were analyzed by 16S rRNA sequencing. Plasma inflammatory markers were measured using enzyme-linked immunosorbent assay. Associations between fecal microbiota, systemic inflammatory markers and clinical characteristics were examined by Spearman partial correlation analysis while controlling for possible confounders. Compared with healthy controls, individuals with MUD showed no difference in fecal microbial diversity, but exhibited differences in the relative abundance of several microbial taxa. At the genus level, a higher abundance of Collinsella, Odoribacter and Megasphaera and lower levels of Faecalibacterium, Blautia, Dorea and Streptococcus were detected in subjects with MUD. More importantly, altered fecal microbiota was found to be correlated with plasma levels of CRP, IL-2, IL-6 and IL-10. The order Lactobacillales, exhibiting lower abundance in participants with MUD, was positively related to the duration of methamphetamine abstinence and the plasma level of anti-inflammatory cytokine IL-10. This study is the first to provide evidence for a link between altered fecal microbiota and systemic inflammation in MUD. Further elucidation of interactions between gut microbiota and the host immune system may be beneficial for the development of novel therapeutic approaches for MUD.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Altered Fecal Microbiota Correlated With Systemic Inflammation in Male Subjects With Methamphetamine Use Disorder

Deng

Song

et al. 2021

Front. Cell. Infect. Microbiol.

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“…Microbial functional analysis revealed that equids in captivity exhibited significant enrichment in nutrient metabolisms such as amino acid, lipid, cofactors, and vitamins metabolism, implying again that the food of captive equids is of higher nutritional value and more abundant food resources. Gut microbes play an essential role in addiction formation ( Qin et al, 2021 ). The increase in the “substance dependence” pathway in captive populations may be related to gut microbiota disturbance caused by excess antibiotics and anthelmintics interventions.…”

Section: Discussionmentioning

confidence: 99%

Wild and Captive Environments Drive the Convergence of Gut Microbiota and Impact Health in Threatened Equids

et al. 2022

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To explore how the living environment influences the establishment of gut microbiota in different species, as well as the extent to which changes in the living environment caused by captive breeding affect wildlife’s gut microbiota and health, we used 16S rRNA gene amplicon sequencing and shotgun metagenomic sequencing to compare the gut microbiome of two species of threatened equids, the Przewalski’s Horse and the Asian wild ass, in the wild and captivity. The results revealed that different species of Equidae living in the same environment showed remarkable convergence of gut microflora. At the same time, captive populations exhibited significantly “unhealthy” microbiota, such as low Alpha diversity, high levels of potentially pathogenic bacteria and biomarkers of physical or psychological disease, and enrichment of microbial functions associated with exogenous exposure and susceptibility, implying that the artificial environment created by captivity may adversely impact the health of wildlife to some extent. Our findings demonstrate the importance of the environmental factors for the establishment of gut microbiota and host health and provide new insights into the conservation of wildlife in captivity from the perspective of the microbiome.

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“…These results imply that MA administration may have effects on the homeostasis of the gut microbiota, which consequently leads to structural and functional brain damage in the organism. In addition, short-chain fatty acids (SCFAs) are produced by the degradation of amino acids by intestinal microbiota and are an important bridge between microbiota and the central nervous system [ 26 ]. SCFAs can enter the blood circulation and exert direct or indirect effects on the organism [ 27 , 28 , 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Aerobic Exercise on Intestinal Microbiota with Amino Acids and Short-Chain Fatty Acids in Methamphetamine-Induced Mice

Liang

Jin

et al. 2023

Metabolites

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This study aimed to investigate the changes in intestinal homeostasis and metabolism in mice after methamphetamine (MA) administration and exercise intervention. In this study, male C57BL/B6J mice were selected to establish a model of methamphetamine-induced addiction, and the gut microbiota composition, short-chain fatty acids (SCFAs), and amino acid levels were assessed by 16S rRNA, liquid chromatography–tandem mass spectrometry, and gas chromatography–tandem mass spectrometry, respectively. The results showed that 23 dominant microbiota, 12 amino acids, and 1 SCFA were remarkably higher and 9 amino acids and 6 SCFAs were remarkably lower in the exercise model group than in the control group. Among the top 10 markers with opposite trends between the exercise intervention group and model group, the differential microbiomes included Oscillibacter, Alloprevotella, Colidextribacter, Faecalibaculum, Uncultured, Muribaculaceae, and Negativibacillus; amino acids included proline; and SCFAs included isovaleric acid and pentanoic acid. Proline was negatively correlated with Negativibacillus and positively correlated with pentanoic acid. The results suggested that moderate-intensity aerobic exercise may modulate changes in the composition of the gut microbiota and the levels of amino acids and SCFAs induced by MA administration.

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Narrative review on potential role of gut microbiota in certain substance addiction

Cited by 22 publications

References 176 publications

Altered Fecal Microbiota Correlated With Systemic Inflammation in Male Subjects With Methamphetamine Use Disorder

Altered Fecal Microbiota Correlated With Systemic Inflammation in Male Subjects With Methamphetamine Use Disorder

Wild and Captive Environments Drive the Convergence of Gut Microbiota and Impact Health in Threatened Equids

Effect of Aerobic Exercise on Intestinal Microbiota with Amino Acids and Short-Chain Fatty Acids in Methamphetamine-Induced Mice

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