Narrow-band imaging as an alternative to chromoendoscopy for the detection of dysplasia in long-standing inflammatory bowel disease: a prospective, randomized, crossover study

Pellisé, María; López-Cerón, María; Miguel, Cristina Rodríguez de; Jimeno, Mireya; Zabalza, Michel; Ricart, Elena; Aceituno, Montserrat; Fernández‐Esparrach, Glòria; Ginès, Pere; Sendino, Oriol; Cuatrecasas, Míriam; Llach, Josep; Panés, Julián

doi:10.1016/j.gie.2011.05.013

Cited by 143 publications

(93 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our present study showed that 7 of the 11 dysplasia/cancer lesions (63.6%) were representative of the neoplastic capillary pattern. Together with the results from recent randomized trials demonstrating that NbI was a reasonable alternative to CE (34)(35)(36)(37), NbI is one of the available modalities to distinguish neoplastic lesion associated with UC.…”

Section: Discussionmentioning

confidence: 89%

Advanced endoscopic features of ulcerative colitis-associated neoplasias: Quantification of autofluorescence imaging

Yoshioka

Mitsuyama

Takedatsu

et al. 2015

International Journal of Oncology

View full text Add to dashboard Cite

Abstract. Ulcerative colitis (UC) patients are well known to carry a higher risk of developing colorectal dysplasia/cancer. However, it is hard to detect the lesion in the early phase during colonoscopy. This pilot study was conducted to analyze the endoscopic characteristics of neoplastic lesions associated with UC using advanced imaging techniques. This is a retrospective analysis of 15 colorectal neoplastic lesion obtained from 11 UC patients during remission who underwent whitelight-and advanced endoscopic imaging techniques, including chromoendoscopy, narrow-band imaging and autofluorescence imaging (AFI), and were treated with surgery. These lesions were analyzed for histology, location, size, shape, color and endoscopic features. The green/red ratio was also assessed to quantify the AFI intensity. All 11 patients had extensive colitis with the median disease duration of 14.0 years. A total of 15 lesions, consisting of 8 high-grade dysplasia and 7 cancer, was mostly located in the distal colon (86.7%, 13/15) with the mean size of 8.6 mm. The shape was protruding in 46.7% (7/15), flat elevated in 40.0% (6/15) and flat in 13.3% (2/15) and the color was red in 60.0% (9/15), same colored in 33.3% (5/15) and discolored in 6.7% (1/15). The lesion predominantly showed Kudo's neoplastic pit pattern in 86.7% (13/15; 5 type IIIL, 7 type IV and 1 type VI) on chromoendoscopy and Sano's neoplastic capillary pattern (type IIIa) in 63.6% (7/11) on narrow-band imaging, but were colored purple as neoplastic lesions in only 37.5% (3/8) on AFI. Of note, the AFI green/red ratio was significantly lower in the neoplastic lesions than UC-involved areas (p=0.00014) and UC-uninvolved areas (p=0.00651) irrespective of the lesion's size and histological type. In conclusion, endoscopic analysis based on advanced imaging, in particular AFI quantitation, may be helpful to detect early stage neoplastic lesions in long standing UC. Large-scale, prospective studies are needed.

show abstract

Section: Discussionmentioning

confidence: 89%

Advanced endoscopic features of ulcerative colitis-associated neoplasias: Quantification of autofluorescence imaging

Yoshioka

Mitsuyama

Takedatsu

et al. 2015

International Journal of Oncology

View full text Add to dashboard Cite

show abstract

“…Similarly, in a randomized delayed crossover design, no difference in dysplasia detection was found [24]. When NBI was compared to chromoendoscopy in 60 patients in a prospective, randomized, crossover design, both techniques showed similar true positive rates for 13 intraepithelial lesions and a lower false-positive rate for NBI, but a trend toward a higher percentage of missed lesions with NBI [25]. As expected, the withdrawal time was lower with NBI (16 vs. 27 min with chromoendoscopy).…”

Section: Endoscopy For Neoplasia Surveillancementioning

confidence: 87%

Endoscopic Surveillance in Inflammatory Bowel Disease

Goetz¹

2018

Visc Med

View full text Add to dashboard Cite

Introduction: Endoscopy is a key technique for the surveillance of patients with inflammatory bowel diseases (Crohn's disease (CD) and ulcerative colitis). Indication to perform endoscopy for surveillance includes assessment of response to therapy, postoperative surveillance, and surveillance for intraepithelial neoplasia. Methods: In addition to personal experience, a literature search was performed and the guidelines were consulted. Results and Conclusion: Endoscopy is the gold standard in the long-term assessment of mucosal healing and in the short-term control of response to intensified therapy. For postoperative surveillance in CD, mucosal changes (as graded by the Rutgeerts score) are predictive of clinical recurrence. For neoplasia surveillance, virtual chromoendoscopy has not (yet) replaced conventional chromoendoscopy. Surveillance can be optimized by the use of high-definition endoscopes as well as (pan-)chromoendoscopy and requires time to scrutinize the mucosa. This approach seems to be superior to random biopsies.

show abstract

“…However, so far, there has been no evidence demonstrating that NBI is better than chromoendoscopy in the detection and diagnosis of IBD-related dysplasia. [9][10] Because of insufficient brightness and relatively dim vision, it is difficult to use classical NBI to observe the mucosa when colonoscope is withdrawn. Although the new-generation NBI system offers brighter vision, still this doesn't mean that it is superior to the chromoendoscopy in screening IBD-related dysplasia.…”

Section: Narrow Band Imaging (Nbi) Is Not Recommendedmentioning

confidence: 99%

Endoscopic diagnosis and treatment of precancerous colorectal lesions in patients with inflammatory bowel disease: How does the latest SCENIC international consensus intersect with our clinical practice?

Qian

2017

Journal of Translational Internal Medicine

View full text Add to dashboard Cite

Narrow-band imaging as an alternative to chromoendoscopy for the detection of dysplasia in long-standing inflammatory bowel disease: a prospective, randomized, crossover study

Cited by 143 publications

References 33 publications

Advanced endoscopic features of ulcerative colitis-associated neoplasias: Quantification of autofluorescence imaging

Advanced endoscopic features of ulcerative colitis-associated neoplasias: Quantification of autofluorescence imaging

Endoscopic Surveillance in Inflammatory Bowel Disease

Endoscopic diagnosis and treatment of precancerous colorectal lesions in patients with inflammatory bowel disease: How does the latest SCENIC international consensus intersect with our clinical practice?

Contact Info

Product

Resources

About