Narrowband UVB phototherapy for early‐stage mycosis fungoides: evaluation of clinical and histopathological changes

Abstract

NB-UVB therapy for patients with early-stage MF is an effective and safe treatment with the effect lasting for months. We suggest that clinical clearance correlates with histological improvement except for patients in the plaque stage.

Clinical, Histological and Immunohistochemical Changes in Hypopigmented Mycosis Fungoides in Response to Narrow-Band UVB Phototherapy

“…We also observed a lack of correlation between the complete clinical response and the histopathological findings in contrary to a previously published observation that clinical remission corresponds to histological remission in the patch stage mycosis fungoides [3]. This fact suggests a possible need of longer UVB-therapy after clinical remission in hypopigmented mycosis fungoides, since histological remission does not correlate with the clinical clearance of the disease and residual MF cells could provoke a clinical relapse and shorted disease-free period, a point that was not covered in the original article.…”

Phototherapy for cutaneous T-cell lymphoma: Online survey and literature review

“…In the literature, the duration for NBUVB initial clearing regimen is based on the time it takes for a patient to clear with definitions of clearance ranging from 90% to 100% clinical clearance of skin lesions. 7,8,[15][16][17][19][20][21][22] The mean number of treatments required to achieve clearance ranged from 19 to 36 treatments. 19,20 Maintenance therapy is an area with greater variation that is notable in both our survey data and the literature.…”

“…7,8,[15][16][17][19][20][21][22] The mean number of treatments required to achieve clearance ranged from 19 to 36 treatments. 19,20 Maintenance therapy is an area with greater variation that is notable in both our survey data and the literature. Within our survey group, 41% of respondents do not use any maintenance NBUVB therapy, whereas the remaining 59% use maintenance with J AM ACAD DERMATOL VOLUME 60, NUMBER 1 varied frequencies from once per week to once per month and durations from less than 1 year to greater than 5 years (Table IV).…”

Cutaneous T-cell lymphoma in skin of color

“…[44][45][46][47][48][49] The availability of phototherapy is largely a reflection of its utility in the management of psoriasis. Currently, there are three types of phototherapy available: broadband UVB (BBUVB), narrowband UVB (NBUVB), and photochemotherapy with psoralen and ultraviolet A (PUVA).…”