Narrowband UVB phototherapy for small plaque parapsoriasis

Aydoğan, Kenan; Karadogan, SK; Tunali, Şükran; Adim, S Balaban; Özçelik, Tülay

doi:10.1111/j.1468-3083.2006.01567.x

Cited by 19 publications

(8 citation statements)

References 22 publications

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“…This regimen is used at our Department for several years and treatment results are satisfactory. The same doses were used also in other studies [1]. …”

Section: Methodsmentioning

confidence: 99%

Narrow band ultraviolet B irradiations cause alteration in interleukin-31 serum level in psoriatic patients

et al. 2012

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Scientific communications indicate the disturbed expression of neuropeptides in the skin and serum in psoriasis vulgaris (PsV) patients. Narrow-band ultraviolet radiation (NB-UVB) is one of the systemic therapies of PsV. The aim of the study was to evaluate the influence of NB-UVB therapy on substance P (SP), calcitonin gene-related peptide (CGRP), brain-derived neurotrophic factor (BDNF), corticotropin-releasing factor (CRF) and interleukin-31 (IL-31) serum concentrations in PsV patients. 59 psoriatic patients with mean PASI (psoriasis area and severity index) 14.3 were treated with NB-UVB (20 exposures). The control group consisted of 50 healthy subjects, whose age and sex matched. In all patients, serum concentration of BDNF, CRF, IL-31 substance P and CGRP was analyzed by ELISA before the treatment and in psoriatic group the analysis was also done after 10 and 20 irradiations. In patients there was found a significantly higher concentration of IL-31 (215.3 vs. 748.6 ng/ml; p < 0.0001), SP (25.7 vs. 67.2 pg/ml; p < 0.01), CGRP (31.4 vs. 44.15 pg/ml; p < 0.01) and a lower concentration of CRF (0.89 vs. 0.426 ng/ml; p < 0.0001) and BDNF (16.39 vs. 14.15 ng/ml; p = 0.1216) in comparison with the controls. 20 NB-UVB exposures caused a significant decrease in IL-31 level (748.6 vs. 631.7 ng/ml; p < 0.0001). The NB-UVB therapy had no major effect on neuropeptides serum levels regardless of a number of irradiations. On the basis of our study it can be suggested that IL-31 is involved in pathogenesis of psoriasis and the NB-UVB therapy causes alterations in its level.

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“…This regimen is used at our Department for several years and treatment results are satisfactory. The same doses were used also in other studies [1]. …”

Section: Methodsmentioning

confidence: 99%

Narrow band ultraviolet B irradiations cause alteration in interleukin-31 serum level in psoriatic patients

et al. 2012

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“…The use of narrowband ultraviolet B (NB‐UVB) phototherapy with a peak emission wavelength at 311 nm has been used for the treatment of psoriasis and other inflammatory disorders for 20 years 6,7 . Some authors have shown that wavelengths between 310 nm and 315 nm provoke the fewest erythema, while being most effective in clearing psoriasis 8 .…”

Section: Introductionmentioning

confidence: 99%

Comparison of the efficacy of local narrowband ultraviolet B (NB‐UVB) phototherapy versus psoralen plus ultraviolet A (PUVA) paint for palmoplantar psoriasis

Sezer¹,

Erbil

Kurumlu

et al. 2007

The Journal of Dermatology

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Palmoplantar psoriasis is an idiopathic disabling condition, often resistant to conventional therapies. The purpose of this study was to evaluate the efficacy and safety of local narrowband ultraviolet B (NB-UVB) phototherapy and to compare it with local psoralen plus ultraviolet A (PUVA) paint in patients with palmoplantar psoriasis unresponsive to conventional therapies other than phototherapy. A cohort of 25 patients with palmoplantar psoriasis were included in this study, which was based on a left-to-right comparison pattern. The treatments were administered with local narrowband UVB irradiation on one side and local PUVA on the other side three times a week over 9 weeks. Clinical assessments were performed at baseline and every 3 weeks during the 9-week treatment. There was a statistically significant decrease in the mean clinical scores at the third, sixth and ninth week with both treatments. The difference in clinical response between the two treatment modalities was statistically significant at the end of the treatment period, with the percentage reduction in severity index scores with the PUVA-paint-treated side being 85.45% compared with 61.08% for the NB-UVB treated side (t = 5.379, P = 0.0001, Student's t-test for unpaired samples). Our results show that, although some clinical improvement was achieved with local NB-UVB phototherapy, the results were better with local PUVA, and such a treatment option may be reserved for patients with palmoplantar psoriasis who experience phototoxic reaction to psoralens.

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“…To parapsoriasis en plaques, our result suggested that hydrogen-water bathing was rapidly effective and safe for the control of the disease with 66.7% partial response and 33.3% complete response. Currently, PUVA and narrow-band UVB are used as main treatment options for parapsoriasis en plaques with up to 80% complete remission rates and a median time to clearance of 2–6 months 6 , 28 , 29 . In general, UVB is preferred in patients with patches and thin plaques and PUVA photochemotherapy should be used for patients with thick plaques, with phototypes ≥III and unresponsive to UVB 6 .…”

Section: Discussionmentioning

confidence: 99%

Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques

Zhu

et al. 2018

Sci Rep

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Psoriasis and parapsoriasis en plaques are chronic inflammatory skin diseases, both representing therapeutic challenge in daily practice and adversely affecting the quality of life. Reactive oxygen species (ROS) has been evidenced to be involved in the pathogenesis of the chronic inflammatory diseases. We now report that hydrogen water, an effective ROS scavenger, has significant and rapid improvement in disease severity and quality of life for patients with psoriasis and parapsoriasis en plaques. At week 8, our parallel-controlled trial revealed 24.4% of patients (10/41) receiving hydrogen-water bathing achieved at least 75% improvement in Psoriasis Area Severity Index (PASI) score compared with 2.9% of patients (1/34) of the control group (Pc = 0.022, OR = 0.094, 95%CI = [0.011, 0.777]). Of patients, 56.1% (23/41) who received bathing achieved at least 50% improvement in PASI score compared with only 17.7%(6/34) of the control group (P = 0.001, OR = 0.168, 95%CI = [0.057, 0.492]). The significant improvement of pruritus was also observed (P = 3.94 × 10−4). Besides, complete response was observed in 33.3% of patients (2/6) of parapsoriasis en plaques and partial response in 66.7% (4/6) at week 8. Our findings suggested that hydrogen-water bathing therapy could fulfill the unmet need for these chronic inflammatory skin diseases.

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Narrowband UVB phototherapy for small plaque parapsoriasis

Cited by 19 publications

References 22 publications

Narrow band ultraviolet B irradiations cause alteration in interleukin-31 serum level in psoriatic patients

Narrow band ultraviolet B irradiations cause alteration in interleukin-31 serum level in psoriatic patients

Comparison of the efficacy of local narrowband ultraviolet B (NB‐UVB) phototherapy versus psoralen plus ultraviolet A (PUVA) paint for palmoplantar psoriasis

Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques

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