A dual-band MIMO antenna with a high isolation is presented in this paper. The proposed MIMO antenna consists of two identical E-shaped micro-strip antennas which are designed on an FR4 substrate. The antenna is designed for radiating at 2.6 GHz and 5 GHz that can be used for the applications of 4G and 5G systems, respectively. Neutral line technique is used for mutual coupling reduction between the E-shaped antenna. Good isolation characteristics are obtained by using single micro-strip line connected between two elements of MIMO antenna. The antenna is fabricated and measured, and good agreement is achieved between the experimental and simulated results.