NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models

McDonald, J. Tyson; Stainforth, R.; Cahill, Thomas J.; Silveira, Willian A. da; Rathi, Komal S.; Hardiman, Gary; Taylor, Deanne; Costes, Sylvain V.; Chauhan, Vinita; Meller, Robert; Beheshti, Afshin

doi:10.3390/cancers12020381

Cited by 20 publications

(18 citation statements)

References 94 publications

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“…Omics analysis has led to many novel discoveries for researchers through advances in genome-wide analysis techniques [ 9 ]. Since the NASA GeneLab database was launched in 2015, the open-access database and its multi-omics format have provided researchers with countless new insights [ 10 , 11 , 12 , 13 , 14 , 15 ]. The NASA GeneLab database stores a variety of open-access, spaceflight-related omics datasets for numerous organisms, including microbes, plants, animals, and humans [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Integrated RNA-seq Analysis Indicates Asynchrony in Clock Genes between Tissues under Spaceflight

Fujita

Rutter

Ong

et al. 2020

Life

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Rodent models have been widely used as analogs for estimating spaceflight-relevant molecular mechanisms in human tissues. NASA GeneLab provides access to numerous spaceflight omics datasets that can potentially generate novel insights and hypotheses about fundamental space biology when analyzed in new and integrated fashions. Here, we performed a pilot study to elucidate space biological mechanisms across tissues by reanalyzing mouse RNA-sequencing spaceflight data archived on NASA GeneLab. Our results showed that clock gene expressions in spaceflight mice were altered compared with those in ground control mice. Furthermore, the results suggested that spaceflight promotes asynchrony of clock gene expressions between peripheral tissues. Abnormal circadian rhythms are associated not only with jet lag and sleep disorders but also with cancer, lifestyle-related diseases, and mental disorders. Overall, our findings highlight the importance of elucidating the causes of circadian rhythm disruptions using the unique approach of space biology research to one day potentially develop countermeasures that benefit humans on Earth and in space.

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Section: Introductionmentioning

confidence: 99%

Integrated RNA-seq Analysis Indicates Asynchrony in Clock Genes between Tissues under Spaceflight

Fujita

Rutter

Ong

et al. 2020

Life

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“…In outer space, it is not possible to grow plants in the sunlight. High-energy heavy-ion charged and solar energetic particles cause genome instabilities, carcinogenesis, tissue degeneration, and neurobehavioral disorders [ 111 ]. Unfortunately, radiation-derived oxidative stress is deleterious also for bone stability [ 112 ], further aggravating the involution of the skeleton.…”

Section: Resultsmentioning

confidence: 99%

“…Summary III. A total of 30 references ([ 17 , 18 , 20 , 24 , 87 , 90 , 91 , 92 , 93 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 ]) were used to scope the following nutritional commonalities between hospital vs. deep space hazards/illnesses. The interest in protecting the musculoskeletal system from reduced mechanical forces that expose the individual to an increased risk of fractures; the environmental consequences on the cardiovascular system; the relevance of stressful situations in causing metabolic and neurobehavioral disturbances; the potential consequences of prolonged periods of solitude.…”

Section: Resultsmentioning

confidence: 99%

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Nutritional Orthopedics and Space Nutrition as Two Sides of the Same Coin: A Scoping Review

Briguglio

2021

Nutrients

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Since the Moon landing, nutritional research has been charged with the task of guaranteeing human health in space. In addition, nutrition applied to Orthopedics has developed in recent years, driven by the need to improve the efficiency of the treatment path by enhancing the recovery after surgery. As a result, nutritional sciences have specialized into two distinct fields of research: Nutritional Orthopedics and Space Nutrition. The former primarily deals with the nutritional requirements of old patients in hospitals, whereas the latter focuses on the varied food challenges of space travelers heading to deep space. Although they may seem disconnected, they both investigate similar nutritional issues. This scoping review shows what these two disciplines have in common, highlighting the mutual features between (1) pre-operative vs. pre-launch nutritional programs, (2) hospital-based vs. space station nutritional issues, and (3) post-discharge vs. deep space nutritional resilience. PubMed and Google Scholar were used to collect documents published from 1950 to 2020, from which 44 references were selected on Nutritional Orthopedics and 44 on Space Nutrition. Both the orthopedic patient and the astronaut were found to suffer from food insecurity, malnutrition, musculoskeletal involution, flavor/pleasure issues, fluid shifts, metabolic stresses, and isolation/confinement. Both fields of research aid the planning of demand-driven food systems and advanced nutritional approaches, like tailored diets with nutrients of interest (e.g., vitamin D and calcium). The nutritional features of orthopedic patients on Earth and of astronauts in space are undeniably related. Consequently, it is important to initiate close collaborations between orthopedic nutritionists and space experts, with the musculoskeletal-related dedications playing as common fuel.

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“…Indeed, the software architecture designed by GeneLab and its strategies around data and metadata harmonization will enable the development of the next generation of space risk models. By classifying experimental factors into digital objects and by transforming raw data into comparable quantitative endpoints using a workflow approved by the community, GeneLab lets users see how space factors affect a large array of biological processes ( 13 , 30–32 ). By establishing mathematical laws describing the relationship between factors’ values and biological endpoints, one can start building more elaborate computer models.…”

Section: Future Directionsmentioning

confidence: 99%

NASA GeneLab: interfaces for the exploration of space omics data

Berrios

Galazka

Grigorev

et al. 2020

Nucleic Acids Research

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The mission of NASA’s GeneLab database (https://genelab.nasa.gov/) is to collect, curate, and provide access to the genomic, transcriptomic, proteomic and metabolomic (so-called ‘omics’) data from biospecimens flown in space or exposed to simulated space stressors, maximizing their utilization. This large collection of data enables the exploration of molecular network responses to space environments using a systems biology approach. We review here the various components of the GeneLab platform, including the new data repository web interface, and the GeneLab Online Data Entry (GEODE) web portal, which will support the expansion of the database in the future to include companion non-omics assay data. We discuss our design for GEODE, particularly how it promotes investigators providing more accurate metadata, reducing the curation effort required of GeneLab staff. We also introduce here a new GeneLab Application Programming Interface (API) specifically designed to support tools for the visualization of processed omics data. We review the outreach efforts by GeneLab to utilize the spaceflight data in the repository to generate novel discoveries and develop new hypotheses, including spearheading data analysis working groups, and a high school student training program. All these efforts are aimed ultimately at supporting precision risk management for human space exploration.

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NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models

Cited by 20 publications

References 94 publications

Integrated RNA-seq Analysis Indicates Asynchrony in Clock Genes between Tissues under Spaceflight

Integrated RNA-seq Analysis Indicates Asynchrony in Clock Genes between Tissues under Spaceflight

Nutritional Orthopedics and Space Nutrition as Two Sides of the Same Coin: A Scoping Review

NASA GeneLab: interfaces for the exploration of space omics data

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