Nasal and bronchial response to exercise in children with seasonal allergic rhinitis out of the pollen season

Harmancı, Koray; Urhan, Barış; Anıl, Hülya; Kocak, Abdulkadır

doi:10.1002/alr.21455

Cited by 6 publications

(5 citation statements)

References 27 publications

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“…The median values of TNAF obtained in our study were 576.7 [519.6; 633.8] cm 3 /s. This is consistent with the data obtained in a study by Harmanci et al [ 41 ], where the TNAF values in BA children were 554±79 cm 3 /s in the pollen season.…”

Section: Discussionsupporting

confidence: 93%

Dependence of Anterior Active Rhinomanometry Indices on Nasal Obstructive Disorders in Children with Atopic Bronchial Asthma Complicated by Nasal Symptoms

Eliseeva

Krasilnikova

Babaev

et al. 2018

BioMed Research International

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Background Atopic bronchial asthma (BA) in children is associated with upper airways pathology (UAP). Among them, a combination of allergic rhinitis (AR) and nasal obstructive disorders (NOD), including hypertrophy of the pharyngeal tonsil (HPT) and anomalies of the intranasal structures (AINS), is abundant. In such patients, anterior active rhinomanometry (AARM) is an important method of examining nasal patency. However, NOD can influence the AARM parameters in children with BA and nasal symptoms, and this effect must be taken into account in clinical practice. Study goal was to elucidate the effect of NOD on rhinomanometric parameters in this group of patients. MethodsTotal of 66 children with BA and AR were examined with AARM, rhinovideoendoscopy, spirometry, and standard clinical tests allowing revealing the structure of comorbid pathologies. In order to avoid the influence of anthropometric parameters of children and their age on AARM parameters, a special index of reduced total nasal airflow was used. ResultsIt has been established that NOD, especially HPT, have a significant negative impact on the indices of anterior active rhinomanometry during the periods of both AR remission and AR exacerbation. The effect of AINS is much weaker and was remarkable only in combination with HPT.

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Section: Discussionsupporting

confidence: 93%

Dependence of Anterior Active Rhinomanometry Indices on Nasal Obstructive Disorders in Children with Atopic Bronchial Asthma Complicated by Nasal Symptoms

Eliseeva

Krasilnikova

Babaev

et al. 2018

BioMed Research International

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“…CARAS is a new medical concept proposed in recent years [17], and two symptoms of allergic rhinitis and asthma are similar in pathogenesis, genetic changes, local pathological changes, immune function and pathogenesis [3,18]. 40% of allergic rhinitis cases are concomitant with asthma while up to 80% of asthma patients are affected by allergic rhinitis [19][20][21].…”

Section: Discussionmentioning

confidence: 99%

MiR-4454 in Combined Allergic Rhinitis and Asthma Syndrome (CARAS): Clinical significance and mechanistic insights into airway inflammation

Zhiguang Liu,

Chuang Sun,

Yujia Shi

et al. 2024

Cell Mol Biol (Noisy-le-grand)

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Abnormal expression of non-coding microRNA is associated with the development of combined allergic rhinitis and asthma syndrome (CARAS). However, the function of miR-4454 in CARAS is unknown. Our study aimed to reveal the clinical significance and related mechanism of miR-4454 in CARAS. Blood samples from 38 cases of CARAS and 43 cases of healthy subjects were collected to detect the expression of miR-4454. House dust mite (HDM) sensitization and challenge-induced bronchial epithelial cells to simulate the asthma state model in vitro, miR-4454 mimics and inhibitor transfection to detect the expression level of pro-inflammatory cytokines, cell survival rate and migration ability, flow cytometry and western blot (WB) Detection of cell cycle, apoptosis and inflammation-related protein levels. Compared with healthy controls, the expression of miR-4454 in the blood of CARAS patients was significantly up-regulated, and IL-6 and IL-8 were significantly up-regulated in the HDM treatment group, indicating that the model induction was successful. After overexpression of miR-4454, cell proliferation and migration in the HDM-treated group were significantly inhibited, and the levels of early apoptosis and inflammation-related proteins (IL-17, IL-17RD, TNF-α, GCSF and NF-κB) were increased High; after inhibiting miR-4454, cell proliferation and migration were significantly enhanced, and the levels of apoptosis and inflammation-related proteins were decreased. This study found that inhibiting the expression of miR-4454 can improve HDM-induced cell injury, which may be related to miR-4454 regulating the activation of IL-17/NF-кB inflammatory axis.

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“…We selected additional covariates based on an extensive review of the literature and group discussion. Other considered covariates included daily temperature (continuous variable), 6,14 daily humidity (continuous variable), 6 day of the week (categorical variable), 14 sex (binary variable), 6 age (continuous variable), 6 body mass index (BMI) (continuous variable), 6 second-hand smoking (binary variable), 16 pet keeping (binary variable), 17 and use of purifiers (binary variable). 18 Because the study period was only in the winter, we introduced temperature into the model without using a spline function.…”

Section: Methodsmentioning

confidence: 99%

The association of ambient PM2.5 with school absence and symptoms in schoolchildren: a panel study

Zhang¹,

Cui

Xu³

et al. 2018

Pediatr Res

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Nasal and bronchial response to exercise in children with seasonal allergic rhinitis out of the pollen season

Abstract: The prevalence of exercise-induced nasal obstruction in children with seasonal rhinitis out of the pollen season is 40%. We showed that minimal persistent inflammation and nasal symptoms can also be diagnosed in rhinitis children in a symptom-free period.

Cited by 6 publications

References 27 publications

Dependence of Anterior Active Rhinomanometry Indices on Nasal Obstructive Disorders in Children with Atopic Bronchial Asthma Complicated by Nasal Symptoms

Dependence of Anterior Active Rhinomanometry Indices on Nasal Obstructive Disorders in Children with Atopic Bronchial Asthma Complicated by Nasal Symptoms

MiR-4454 in Combined Allergic Rhinitis and Asthma Syndrome (CARAS): Clinical significance and mechanistic insights into airway inflammation

The association of ambient PM2.5 with school absence and symptoms in schoolchildren: a panel study

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