Nasal and nasal-type T/NK-cell lymphoma with cutaneous involvement

Kato, Naoko; Yasukawa, Kana; Onozuka, Takashi; Kikuta, Hídeaki

doi:10.1053/jd.1999.v40.a94087

Cited by 43 publications

(33 citation statements)

References 26 publications

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“…6 On the other hand, in a recent study, we reported that the most common primary cutaneous lymphomas in Taiwan are extranodal NK/T-cell lymphoma, nasal type, and PTCL-NOS. [3][4][5] Our current case fits well both into the extranodal NK/T cell lymphoma, nasal type by the WHO/EORTC scheme, and 2008 WHO classification. However, we believe that this case could also be classified as an EBV-positive PTCL-NOS with a cytotoxic phenotype.…”

Section: Discussionsupporting

confidence: 60%

“…2 Extranodal NK/T-cell lymphoma presenting in the skin, either primarily or secondarily, is relatively rare and is usually associated with an aggressive clinical course. [3][4][5] In this report, we present the case of an aggressive lymphoma of T-cell lineage with cutaneous presentation. We discuss the differential diagnosis using the 2005 World Health Organization/ European Organization for Research and Treatment of Cancer (WHO/EORTC) classification scheme for cutaneous lymphomas and 2008 WHO classification scheme for lymphoid neoplasms, in addition to the prognostic impact of NK vs. T-cell lineage on extranodal NK/T-cell lymphomas.…”

Section: Introductionmentioning

confidence: 99%

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Cutaneous Peripheral T-Cell Lymphoma of Cytotoxic Phenotype Mimicking Extranodal NK/T-Cell Lymphoma

Pan

Wen-sen

Murphy

et al. 2011

The American Journal of Dermatopathology

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Cutaneous peripheral T-cell lymphoma unspecified is a rare neoplasm that is infrequently associated with Epstein-Barr virus (EBV) infection. In contrast, extranodal natural killer (NK)/T-cell lymphoma, although also rare, is known to be strongly associated with EBV and occurs most commonly in the nasal region. We report the case of a 55-year-old male who presented with fever and an indurated cutaneous plaque with ulceration. This cutaneous neoplasm showed diffuse dermal lymphomatous infiltration and tumor necrosis, with neoplastic cells expressing CD2, cytoplasmic CD3 (CD3ε), CD8, CD16, CD30, T-cell intracellular antigen-1, and granzyme B but not CD56, BF1, or T-cell receptor (TCR) δ1. Furthermore, the tumor cells were noted to be diffusely positive for EBV by in situ hybridization. A monoclonal TCR gene rearrangement was demonstrated. The disease showed an aggressive clinical course, and the patient died within 3 weeks of diagnosis without complete staging or chemotherapy. According to the 2005 World Health Organization/European Organization for Research and Treatment of Cancer scheme for cutaneous lymphoma and the 2008 WHO classification for lymphoid neoplasms, our case would have been classified as a nasal type extranodal NK/T-cell lymphoma with T-cell lineage. However, the expressions of CD8 and CD16, in addition to a monoclonal TCR gene rearrangement, are unusual findings in NK/T-cell lymphoma, and we believe such a phenotype/genotype should be more appropriately classified as an EBV-positive peripheral T-cell lymphoma, unspecified with a cytotoxic phenotype. Detailed clinicopathologic and molecular studies of similar cases may shed light on the prognostic impact of NK vs. T-cell lineage on extranodal NK/T-cell lymphomas.

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Section: Discussionsupporting

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Cutaneous Peripheral T-Cell Lymphoma of Cytotoxic Phenotype Mimicking Extranodal NK/T-Cell Lymphoma

Pan

Wen-sen

Murphy

et al. 2011

The American Journal of Dermatopathology

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“…6 Histologically, this type of lymphoma is characterized by a medium-to large-sized atypical lymphocytic infiltrate with angiocentric and angiodestructive features. 4,6,[8][9][10][11][12][13] Epidermotropism has been observed in some cases. 6,8,9,11,13,14 Immunostaining is positive for cytoplasmic CD3 and CD56 but negative for CD4 or CD8.…”

Section: Discussionmentioning

confidence: 99%

NK-/T-Cell Lymphoma Resembling Hydroa Vacciniforme With Positive CD4 Marker Expression

Zhang

Bai²,

Yang³

et al. 2013

The American Journal of Dermatopathology

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A 35-year-old Chinese woman presented with a 2.5-year history of facial swelling in the left lower quadrant and a 10-month history of relapsing red papules and vesicles in the perioral area resembling hydroa vacciniforme. Histologically, a tissue biopsy showed a dense infiltration of medium-sized atypical lymphocytic cells expressing CD4 and CD56. A diagnosis of cutaneous NK-/T-cell lymphoma was made. The patient was treated with alpha-interferon, valaciclovir hydrochloride, and low-dose prednisone for 2 months. Her skin lesions and lymphoadenopathy resolved initially, but she succumbed to the disease shortly after starting chemotherapy treatment 11 months later. To our knowledge, this is the first case of CD4CD56 NK-/T-cell lymphoma with clinical features resembling hydroa vacciniforme.

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“…To date, no conclusive theory has been described to explain why this type of lymphoma remains confined to these unusual locations. 22 We hope that our experience might help in the understanding of this very rare disease.…”

Section: Discussionmentioning

confidence: 90%

“…Therefore, the standard CHOP therapy was chosen in order to improve the overall condition of the patient. 22 …”

Section: Discussionmentioning

confidence: 99%

Primary NK/T cell lymphoma nasal type of the stomach with skin involvement: a case report

et al. 2009

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Since nasal NK/T cell lymphoma and NK/T cell lymphoma nasal type are rare diseases, gastric involvement has seldom been seen. We report a unique case of a patient with a primary NK/T cell lymphoma nasal type of the stomach with skin involvement. The patient had no history of malignant diseases and was diagnosed with hematemesis and intense bleeding from his gastric primary site. Shortly after this event, exanthemic skin lesions appeared with concordant histology to the primary site. Despite chemotherapy, the patient died one month after the first symptomatic appearance of disease.

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Nasal and nasal-type T/NK-cell lymphoma with cutaneous involvement

Cited by 43 publications

References 26 publications

Cutaneous Peripheral T-Cell Lymphoma of Cytotoxic Phenotype Mimicking Extranodal NK/T-Cell Lymphoma

Cutaneous Peripheral T-Cell Lymphoma of Cytotoxic Phenotype Mimicking Extranodal NK/T-Cell Lymphoma

NK-/T-Cell Lymphoma Resembling Hydroa Vacciniforme With Positive CD4 Marker Expression

Primary NK/T cell lymphoma nasal type of the stomach with skin involvement: a case report

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