Nasal Application of Immunotherapy

Ascione, Ester; Lucia, Adriana De; Imperiali, M.; Varricchio, Attilio; Motta, G

doi:10.1159/000071543

Cited by 6 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3 Some other routes have been explored: the bronchial route was abandoned due to the frequency of local and systemic symptoms. 4 The intranasal route has been tried since the late 90s by Italian teams, 5,6 has been marketed in this country and still appears in a recent Taiwanese publication; 7 the oral route failed to demonstrate efficacy in respiratory allergies but seems promising in food allergy treatment; 8 the epicutaneous route, using patch tests (applied on the skin for a period of one to several days) was studied with grass pollens in one publication where efficacy in lowering allergic rhinitis symptoms was demonstrated. 9 Finally, a new promising route of administration has been recently explored with intralymphatic allergen injections.…”

Section: Introductionmentioning

confidence: 99%

Specific immunotherapy in grass pollen allergy

Mailhol

Didier²

2012

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Specific immunotherapy in grass pollen allergy

Mailhol

Didier²

2012

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

“…26,27 Twenty-two studies were included for qualitative evaluation. Data could not be extracted from one study, 28 and another was excluded because it was the continuation of another study. 29 Note that two studies were separate reports of the clinical response 30 and the immunological response of a single clinical trial.…”

Section: Study Selectionmentioning

confidence: 99%

Local nasal immunotherapy for allergic rhinitis: A systematic review and meta‐analysis

Kasemsuk

Ngaotepprutaram

Kanjanawasee

et al. 2022

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

Introduction Local nasal immunotherapy (LNIT), an alternative noninjection immunotherapy method, is theoretically an efficient method for inducing immunotolerance directly in the affected organ. LNIT is more convenient and less invasive than injection immunotherapy, with fewer systemic reactions. The development of adjuvants to overcome LNIT's limitations raises the possibility of it being an alternative allergen immunotherapy. Objectives To evaluate the clinical and immunological efficacy and safety of LNIT for patients with allergic rhinitis. Methods A systematic search for randomized controlled trials comparing LNIT and placebo was performed using OVID Medline and Embase. Outcomes were total nasal symptom score (TNSS), symptom–medication score (SMS), medication score, immunological assessment, and nasal provocation threshold. Data were pooled for meta‐analysis. Results A total of 20 studies with 698 participants were included. The LNIT group had greater posttreatment improvement in TNSS, SMS, and medication score than control (TNSS: standardized mean difference [SMD], –1.37 [95% confidence interval [CI], –2.04 to –0.69]; SMS: SMD, –1.55 [95% CI, –2.83 to –0.28]; and medication score: SMD, –1.09 [95% CI, –1.35 to –0.83]). Immunological assessments showed no significant differences in serum‐specific IgE (mean difference [MD], 6.35; 95% CI, –4.62 to 17.31), nasal IgE (MD, –0.59; 95% CI, –1.99 to 0.81), or nasal eosinophil cationic protein (MD, 7.63; 95% CI, –18.65 to 33.91). Only serum IgG significantly increased with LNIT (MD, 0.45; 95% CI, 0.20, 0.70). Posttreatment, nasal provocation threshold was higher with LNIT (MD, 27.30; 95% CI, 10.13–44.46). No significant adverse events were reported. Conclusions LNIT is a safe alternative allergen immunotherapy route without significant adverse events. It improves clinical symptoms, reduces medication usage, and increases the nasal provocation threshold.

show abstract

“…We conducted a meta‐analysis to evaluate the effectiveness of allergen immunotherapy. In Medline, we performed a search using the key phrase “allergic rhinitis and immunotherapy and clinical study,” and obtained results of 114 placebo‐controlled clinical trials conducted from 2003 to 2013. To ensure a homogeneous distribution, 56 works were included in our study (Supporting Information Table S1; in the supplemental material).…”

mentioning

confidence: 99%