Nasal manifestations of Crohn's disease

Abstract

Flg. 1. Multiple superficial ulcerations were present on the palate, tongue, and oral vestibule (orrows).

Nasal Septal Perforation in an Adolescent Girl with Crohn’s Disease: A Rare Extraintestinal Manifestation

“…In the literature, histologic findings of nasal CD were reported as chronic inflammatory changes similar to our case [3,8]. Authors demonstrated that in CD nasal histologic findings are similar to oral lesions where granulomas are detected in only 10-68% of specimens [11].…”

“…Ernst et al [7] described the case of a 17-year-old girl who had pansinusitis with polipoidal changes. Pochon et al [8] and Ulnick et al [9] described nasal obstruction in two adults. A fifth case, the only one involving a nasal perforation, was a 12-year-old boy reported by Kriskowich et al [3].…”

Nasal septal ulceration

“…Nasal disease and septal involvement are quite rare. 22 Symptoms of nasal Crohn's typically include obstruction, rhinorrhea, and epistaxis and examination reveals atrophic rhinitis, chronic mucosal inflammation, and granuloma formation. Mucosal oedema, chronic inflammation, and polypoidal changes involving septum or turbinates may be found.…”

“…Mucosal oedema, chronic inflammation, and polypoidal changes involving septum or turbinates may be found. 22 Histologic findings are variable and granulomas may or may not be present. Steroids are the mainstay of treatment.…”

Saddle nose deformity, palatal perforation and truncus arteriosus in a patient with Crohn’s disease

“…The mucocutaneous manifestations of Crohn's disease in the orofacial region are multiple, including oral Crohn's disease, metastatic Crohn's disease in sites noncontiguous with the bowel system, and reactive disorders such as pyoderma gangrenosum . Nasal manifestations are extremely rare and only a few cases have been reported up to date in the literature (Kinnear, 1985;Ghandour and Issa, 1991;Ernst et al, 1993;Pochon et al, 1995;Ferjaoui et al, 1999;Kriskovich et al, 2000;Ulnick and Perkins, 2001;Venail et al, 2002;Merkonidis et al, 2005;Kryssia and Henry, 2006;Sari et al, 2007;Michailidou et al, 2009). Persistent truncus arteriosus is an uncommon congenital cardiac malformation accounting for approximately 1.2% of all congenital heart malformations (Friedman, 1997;Williams et al, 1999).…”