Nasal mucosal histamine reactivity among young students and teachers, having no or prolonged exposure to a deteriorated indoor climate

Rudblad, Stig; Andersson, Kjell; Bodin, Lennart; Stridh, Göran; Juto, Jan-Erik

doi:10.1034/j.1398-9995.2002.23682.x

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…Positive, non-immune responses were observed in the subjects. Probably, the responses consisted of mediator-type reactions involving the responses from the sympathetic system, the parasympathetic system, and the receptors present in the nasal mucosa [20,21]. This reaction was probably due to the effects of substances contained in drinking milk such as fats and carbohydrates.…”

Section: A B Cmentioning

confidence: 99%

Reactivity of nasal cavity mucosa in the nasal cow’s milk allergen provocation test

Krzych‐Fałta¹,

Wojas²,

Namysłowski³

et al. 2023

pdia

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Introduction:The nasal allergen provocation test plays an important role in differential diagnostics of rhinitis. Due to its informative potential, the test is also becoming increasingly used in other areas of diagnostics, including the diagnostics of food allergies. Aim: To assess the reactivity of nasal mucosa to the cow's milk protein allergens (as being widely used in powdered form in the food industry). Material and methods:The study material consisted of a group of 31 healthy subjects not sensitized to environmental allergens including cow's milk protein allergens. The study method involved an incremental nasal provocation test with cow's milk protein evaluated using the visual analog scale and acoustic rhinometry. Results: A total of 29 out of 31 volunteers presented with a significant decrease in nasal patency (control solution: 1.112 ±0.161 vs. local allergen application 1.005 ±0.157; p < 0.004) as measured by acoustic rhinometry following the allergen dose of 12.5 µg. Slight changes in complaints were observed using the visual analog scale. Exposure to the widespread food allergens (including powdered cow's milk allergens) presents a potential risk of positive response in non-sensitized individuals. Conclusions: Further studies on dose standardization are necessary in the study area.

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Section: A B Cmentioning

confidence: 99%

Reactivity of nasal cavity mucosa in the nasal cow’s milk allergen provocation test

Krzych‐Fałta¹,

Wojas²,

Namysłowski³

et al. 2023

pdia

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“…Cutaneous exposure is known to result in dermatitis, primarily in atopic patients [ 27 , 28 ]. Respiratory exposure to histamine can reduce forced expiratory volume (FEV) [ 29 ], and increase nasal mucosa reactivity [ 30 ], with these effects mostly seen in atopic individuals [ 31 ]. Dermal, nasal, or respiratory responses (e.g., bronchial reactivity) [ 32 , 33 ] to histamine in clinical tests suggest that exposure to histamine in the environment would constitute a significant health risk, although information on environmental exposure is limited.…”

Section: Introductionmentioning

confidence: 99%

Histamine as an emergent indoor contaminant: Accumulation and persistence in bed bug infested homes

et al. 2018

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Histamine is used in bronchial and dermal provocation, but it is rarely considered an environmental risk factor in allergic disease. Because bed bugs defecate large amounts of histamine as a component of their aggregation pheromone, we sought to determine if histamine accumulates in household dust in bed bug infested homes, and the effects of bed bug eradication with spatial heat on histamine levels in dust. We collected dust in homes and analyzed for histamine before, and up to three months after bed bug eradication. Histamine levels in bed bug infested homes were remarkably high (mean = 54.6±18.9 μg/100 mg of sieved household dust) and significantly higher than in control homes not infested with bed bugs (mean < 2.5±1.9 μg/100 mg of sieved household dust). Heat treatments that eradicated the bed bug infestations failed to reduce histamine levels, even three months after treatment. We report a clear association between histamine levels in household dust and bed bug infestations. The high concentrations, persistence, and proximity to humans during sleep suggest that bed bug-produced histamine may represent an emergent contaminant and pose a serious health risk in the indoor environment.

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Association of parent-reported health symptoms with indoor air quality in primary school buildings – The InAirQ study

Szabados

Kakucs

Páldy

et al. 2022

Building and Environment

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Nasal mucosal histamine reactivity among young students and teachers, having no or prolonged exposure to a deteriorated indoor climate

Cited by 4 publications

References 33 publications

Reactivity of nasal cavity mucosa in the nasal cow’s milk allergen provocation test

Reactivity of nasal cavity mucosa in the nasal cow’s milk allergen provocation test

Histamine as an emergent indoor contaminant: Accumulation and persistence in bed bug infested homes

Association of parent-reported health symptoms with indoor air quality in primary school buildings – The InAirQ study

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