Nasal Packing with Strips of Cured Pork as Treatment for Uncontrollable Epistaxis in a Patient with Glanzmann Thrombasthenia

Humphreys, Ian; Saraiya, Sonal; Belenky, Walter M.; Dworkin, James Paul

doi:10.1177/000348941112001107

Cited by 6 publications

(4 citation statements)

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“…Overall, 49 patients were identified in case reports and were treated with rFVIIa for 36 bleeding episodes and 29 surgical procedures . Patients ranged in age from 1 to 60 years; 53% were female and 47% were male (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…In all, 40 case reports were identified that included 49 patients in whom rFVIIa was used as part of their treatment regimen; in six case reports, the same patient was treated for bleeding episodes and surgical procedures. Twenty‐four case reports described 29 patients treated for 36 bleeding episodes, and 22 case reports described 27 patients treated for 29 invasive, surgical or dental procedures.…”

Section: Methodsmentioning

confidence: 99%

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Use of recombinant activated factor VII in patients with Glanzmann's thrombasthenia: a review of the literature

et al. 2014

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Glanzmann's thrombasthenia (GT) is a rare bleeding disorder characterized by a quantitative or qualitative defect of glycoprotein IIb/IIIa on the platelet membrane. Managing bleeding episodes is often difficult, and a variety of modalities have been used, including platelet transfusions, recombinant factor VIIa (rFVIIa), and other supportive care. The aim of this review was to present the clinical experience with rFVIIa bolus infusion (rFVIIa BI) for treatment of bleeding episodes and prevention of bleeding during surgical procedures in patients with GT. A literature search was performed to identify rFVIIa-treated patients with GT. Overall, one international survey, one open-label study, and 40 case reports identified 172 bleeding episodes treated with rFVIIa and 62 procedures covered with rFVIIa. In the international survey, rFVIIa BI was used for 96 bleeding episodes in 59 patients. Recombinant FVIIa was effective in 76 bleeding episodes (79%). Of 34 surgical procedures, 25 procedures received rFVIIa BI with 92% bleeding-prevention efficacy. The open-label study reported 28 patients with 28 rFVIIa BI-treated bleeds, and 26 (93%) bleeding episodes responded to rFVIIa. Published case reports revealed that 25 (69%) of 36 bleeds and 27 (96%) of 28 surgeries responded to rFVIIa BI treatment. Overall, 26 adverse events were reported in 19 patients, including five thromboembolic events in two patients where a possible relationship with rFVIIa could not be excluded. Two large studies and 40 case reports provide a literature base to support the efficacy and safety of rFVIIa BI in patients with GT.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Use of recombinant activated factor VII in patients with Glanzmann's thrombasthenia: a review of the literature

et al. 2014

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“…This real‐time case study has informed my decision to pass on the funding announcement that arrived in my inbox today. After all, many landmark papers have been published without NIH funding …”

Section: Discussionmentioning

confidence: 99%

The Folly of the R: A Case Study

Rodriguez

2019

Academic Emergency Medicine

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“…5 The intervention stopped bleeding "promptly, effectively, and without sequelae" on two occasions. Nasal bleeding stopped within 24 hours, and the patient was discharged within 72 hours.…”

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confidence: 97%

Seeing Jesus in a piece of toast and other scientific discoveries win Ig Nobel awards

Tanne¹

2014

BMJ

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Nasal Packing with Strips of Cured Pork as Treatment for Uncontrollable Epistaxis in a Patient with Glanzmann Thrombasthenia

Abstract: To our knowledge, this represents the first description of nasal packing with strips of cured pork for treatment of life-threatening hemorrhage in a patient with Glanzmann thrombasthenia.

Cited by 6 publications

References 11 publications

Use of recombinant activated factor VII in patients with Glanzmann's thrombasthenia: a review of the literature

Use of recombinant activated factor VII in patients with Glanzmann's thrombasthenia: a review of the literature

The Folly of the R: A Case Study

Seeing Jesus in a piece of toast and other scientific discoveries win Ig Nobel awards

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