Nasal polyposis: eosinophils and interleukin‐5

Krämer, Matthias; Rasp, Gerd

doi:10.1034/j.1398-9995.1999.00095.x

Cited by 71 publications

(67 citation statements)

References 101 publications

(158 reference statements)

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“…A PN geralmente se manifesta em pacientes com idade superior a 20 anos 17 . A manifestação em crianças é muito rara, com uma incidência relatada de 0,1%, devendo nestes casos ser suspeitada fibrose cística 13,15 .…”

Section: Discussionunclassified

“…Três (15%) pacientes adultos apresentavam asma brônquica e dois (10%) destes, também intolerância a AINES, formando a "tríade de Widal", também conhecida como "tríade de Samter". A PN está presente em várias doenças sistêmicas, sendo a asma intrínseca ou não alérgica a associação mais comum nos adultos e muito raramente em crianças 2,16,17 . Este tipo de asma tem aparecimento após os 30 anos de idade e a PN aparece ao redor dos 40.…”

Section: Discussionunclassified

“…No caso da tríade de "Widal", a asma costuma ser grave e corticodependente 2 . Aproximadamente 20-50% dos pacientes com PN apresentam asma brônquica 17 . Bent et al 5 afirmaram que muitos pacientes com SFA apresentam sintomas intensos de asma devido à sinusite crônica.…”

Section: Discussionunclassified

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Pesquisa de fungos em 20 pacientes com polipose nasossinusal

Monteiro

França

Bergter

et al. 2002

Rev. Bras. Otorrinolaringol.

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Section: Discussionunclassified

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Pesquisa de fungos em 20 pacientes com polipose nasossinusal

Monteiro

França

Bergter

et al. 2002

Rev. Bras. Otorrinolaringol.

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“…Thus there is a vicious cycle between eosinophils and TNF-α production in the NP tissue. The major source of TNF-α in NP tissue is eosinophils (15). TNF-α upregulates vascular cell adhesion molecule-1 (VCAM-1) expression in fibroblasts, and this in turn increases the trans-migration of eosinophils to the inflammation site and leads to even more TNF-α production (16).…”

Section: Discussionmentioning

confidence: 99%

TNF-α and IL-1 β Cytokine Gene Polymorphism in Patients with Nasal Polyposis

İsmi¹,

Özcan²,

Polat³

et al. 2017

Turk Arch Otorhinolaryngol

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Objective: Nasal Polyp (NP) is a benign mass of the paranasal sinuses that protrudes into the nasal cavity. The exact underlying pathogenesis is not known. In this study we aimed to determine the genetic susceptibility of NP formation in relation to TNF-α-308 and IL-1β-511 promoter region gene polymorphisms. Methods:A total of 71 patients with NP with asthma (n=21) or without asthma (n=50) were taken as the study group, and 91 healthy volunteers were taken as the control group. Blood was gathered into EDTA-containing tubes, and patient DNA was extracted. The polymorphisms of the IL-β and TNF-α cytokine genes were analyzed using real time polymerase chain reaction. Results:The GG genotype in the TNF-α-308 region and the CC genotype in the IL-1β-511 region were found to be risk factors for NP formation (OR: 9.2, p=0.007 and OR: 33.3, p=0.001, respectively). Regarding allelic frequencies, the G allele at the TNF-α-308 promoter region was a risk factor for NP formation (OR: 6.06, p<0.001).Conclusion: TNF-α GG genotype in the -308 promoter region and the IL-1β CC genotype in the -511 region are genetic risk factors for NP formation.

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“…They are an outcome of varying disease processes and generally caused by the chronic inflammation. 1,2 Factors which contribute to the localization of nasal polyps may include the mucociliary flow, blood vessels and nerve endings within the mucous membranes near the border between the nose and paranasal sinuses.…”

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confidence: 99%