Nasal route for vaccine and drug delivery: Features and current opportunities

Mato, Yadira Lobaina

doi:10.1016/j.ijpharm.2019.118813

Cited by 109 publications

(63 citation statements)

References 118 publications

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“…For instance, intranasal administration has long been exploited for delivering drugs to the human respiratory tract, for both therapeutic and recreational purposes (Parhi 2020). Intranasal administration can provide both systemic and localized treatment for respiratory diseases, which can be easily administered by the users themselves (Mato 2019). Recent studies show potent immune response throughout the body with particularly high immunity in the nose and respiratory tract against SARS-CoV-2 via intranasal administration of spike proteins carried by harmless adenovirus (Feng et al 2020;Hassan et al 2020).…”

Section: Mail-in Vaccinesmentioning

confidence: 99%

Who is running faster, the virus or the vaccine?

Han

Lichtfouse

2020

Environ Chem Lett

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Section: Mail-in Vaccinesmentioning

confidence: 99%

Who is running faster, the virus or the vaccine?

Han

Lichtfouse

2020

Environ Chem Lett

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“…The nasal cavity is a strategic gateway for drug delivery in conventional topical pharmacotherapy of sino-nasal diseases such as allergic and non-allergic rhinitis and rhinosinusitis, but also for drugs intended for systemic circulation. 171 Optimal nasal drug delivery is hindered partly by the intrinsic geometry of the nose and its functional properties, namely the nasal valve and the cyclic physio-morphological alteration of its turbinates, respectively. In other words, the incongruity between the nasal inlet geometry and the different nasal plumes causes only a fraction of the drug to be deposited in the target area.…”

Section: Devices Used For Treatmentmentioning

confidence: 99%

Medical devices in allergy practice

Popov

Passalacqua

González‐Díaz

et al. 2020

World Allergy Organization Journal

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Medical devices provide people with some health benefits in terms of diagnosis, prevention, treatment, and monitoring of disease processes. Different medical specialties use varieties of medical devices more or less specific for them. Allergology is an interdisciplinary field of medical science and teaches that allergic reactions are of systemic nature but can express themselves at the level of different organs across the life cycle of an individual. Subsequently, medical devices used in allergology could be regarded as: 1) general, servicing the integral diagnostic and management principles and features of allergology, and 2) organ specific, which are shared by organ specific disciplines like pulmonology, otorhinolaryngology, dermatology, and others. The present position paper of the World Allergy Organization (WAO) is meant to be the first integral document providing structured information on medical devices in allergology used in daily routine but also needed for sophisticated diagnostic purposes and modern disease management. It is supposed to contribute to the transformation of the health care system into integrated care pathways for interrelated comorbidities.

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“…Due to the different connection of the nose and the CNS, the olfactory route can deliver pharmacological active agents into the brain by crossing the BBB. The absorption of drug across the olfactory area of the nose offers a different feature and greater option to targeting drugs into brain [84,85]. Drug administered through intranasal route of administration is absorbed by the systemic circulation.…”

Section: Intranasal Deliverymentioning

confidence: 99%