Nasal T‐cell lymphoma causally associated with Epstein‐Barr virus: Clinicopathologic, phenotypic, and genotypic studies

Harabuchi, Yasuaki; Imai, Shosuke; Wakashima, Junichi; Hirao, Motoyasu; Kataura, Akikatsu; Õsato, Toyoro; Kon, Shinichiro

doi:10.1002/(sici)1097-0142(19960515)77:10<2137::aid-cncr27>3.3.co;2-n

Cited by 44 publications

(72 citation statements)

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“…Recent studies have revealed that a higher percentage (50-100%) of nasal T-cell lymphomas are associated with EBV, regardless of the geographic origin of the patients [2,12,13,15,17,21,24,30]. Chan et al reported 94.1% EBV positivity of non-nasal NK/T-cell lymphomas, and they emphasized an aetiological role for EBV in NK/T-cell lymphoma [7].…”

Section: Discussionmentioning

confidence: 99%

Primary natural killer/T-cell lymphomas of the oral cavity are aggressive neoplasms

et al. 1999

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Thirty-four cases of primary non-Hodgkin's lymphoma of the oral cavity were investigated for their clinical findings, histopathological features, immunophenotypes and association with Epstein-Barr virus (EBV). Four cases (12%) were natural killer/T-cell lymphomas, 3 (9%) were T-cell lymphomas and 27 (79%) were Bcell lymphomas. Compared with T-and B-cell lymphomas, NK/T-cell lymphomas had a male predominance (M:F 4:0), and most presented as ulceration of the palate and/or maxillary gingiva. Histologically, the lesions showed diffuse infiltration of medium-sized or large lymphoid tumour cells. Angiocentricity and/or angioinvasion were found in all 4 cases. The immunophenotypes of the NK/T-cell lymphomas were CD3+, CD43+, CD45RO+, CD56+ and TIA-1+. EBV was detected in 2 NK/T-cell lymphomas by in situ hybridization (ISH) and polymerase chain reaction (PCR) methods, and was not detected in T-and B-cell lymphomas. The survival rate of patients with NK/T-cell lymphoma was zero, but the survival rates for patients with T-cell and B-cell lymphomas were 67% and 38%, respectively. It appears that NK/T-cell lymphomas of the oral cavity have a predilection for originating in the palate and maxillary gingiva and are aggressive neoplasms. EBV positivity might be associated with more aggressive behaviour.

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Section: Discussionmentioning

confidence: 99%

Primary natural killer/T-cell lymphomas of the oral cavity are aggressive neoplasms

et al. 1999

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“…1a-c). 1,3 The tumor is locally invasive and often infi ltrates the surrounding tissues and organs such as skin, paranasal sinus, and orbits, resulting in the generation of extensive destructive midfacial lesions. 1,18,27 Nasal obstruction and/or bloody rhinorrhea are the most common symptoms at the time of diagnosis.…”

Section: Clinical Characteristicsmentioning

confidence: 99%

“…Epidemiologically, the lymphoma is common in East Asia [1][2][3][4][5] and Latin America, 2,6 but it is quite rare in the United States and Europe. [7][8][9] Clinically, the lymphoma is characterized by progressive necrotic lesions, mainly in the nasal cavity, and a poor prognosis caused by the rapid progression of the lesion into distinct organs.…”

Section: Introductionmentioning

confidence: 99%

“…[7][8][9] Clinically, the lymphoma is characterized by progressive necrotic lesions, mainly in the nasal cavity, and a poor prognosis caused by the rapid progression of the lesion into distinct organs. 3,5,10 Histologically, the features of this lymphoma include angiocentric and polymorphous lymphoreticular infi ltrates, which are called polymorphic reticulosis. 11,12 Recent studies have revealed that the origin of the lymphoma is either NK or T-cell (especially γδT-cell) lineage, both of which express the NK cell marker, CD56.…”

Section: Introductionmentioning

confidence: 99%

“…11,12 Recent studies have revealed that the origin of the lymphoma is either NK or T-cell (especially γδT-cell) lineage, both of which express the NK cell marker, CD56. 3,9,[13][14][15][16] Regarding the etiological characteristics of the lymphoma, we 1,3,17 fi rst demonstrated the presence of Epstein-Barr virus (EBV) DNA, EBV oncogenic proteins, and the clonotypic EBV genome in the lymphoma. The characteristics of the lymphoma are summarized in Table 1.…”

Section: Introductionmentioning

confidence: 99%

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Nasal natural killer (NK)/T-cell lymphoma: clinical, histological, virological, and genetic features

et al. 2009

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Nasal natural killer (NK)/T-cell lymphoma (NNKTL) is a clinical illness characterized by progressive unrelenting ulceration and necrosis of the nasal cavity and midline facial tissues. Histological features of the lymphoma include angiocentric and polymorphous lymphoreticular infiltrates, called polymorphic reticulosis. Surface antigens and the NK-cell marker, CD56, as well as pan-T antigen CD2, cytoplasmic CD3 (CD3epsilon), and CD45 are expressed in the lymphoma cells. The origin of the lymphoma is thought to be either NK-cell linkage without T-cell receptor (TCR) rearrangement or gammadeltaT-cell linkage with gammadeltaTCR rearrangement. Since the authors of this study first demonstrated the presence of Epstein Barr virus (EBV)-DNA and EBV oncogenic proteins in NNKTL, the lymphoma has been classified as one of the EBV-associated malignancies. The NNKTL cells produce interleukin (IL)-9, IL-10, and interferon-gamma-inducible protein-10 (IP-10), possibly due to EBV-oncogenic proteins in the lymphoma cells, and such cytokines take an important part in the cell proliferation and invasion, acting in an autocrine manner. Clinically, the serum EBV-DNA copy number is useful as a specific tumor marker and a predictive prognostic factor. Even in early clinical stages, the lymphoma shows poor prognosis caused by the rapid progression of the lesion into distinct organs. Our newly designed arterial infusion chemotherapy, from the superficial temporal artery, in combination with radiotherapy, has shown a favorable outcome in patients with NNKTL. In this article, the clinical, pathological, and virological characteristics of the lymphoma are reviewed, along with a report of our investigations.

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Clinicopathologic Manifestations of Epstein-Barr Virus—Associated Cutaneous Lymphoproliferative Disorders

Iwatsuki¹

1997

Arch Dermatol

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Nasal T‐cell lymphoma causally associated with Epstein‐Barr virus: Clinicopathologic, phenotypic, and genotypic studies

Cited by 44 publications

References 1 publication

Primary natural killer/T-cell lymphomas of the oral cavity are aggressive neoplasms

Primary natural killer/T-cell lymphomas of the oral cavity are aggressive neoplasms

Nasal natural killer (NK)/T-cell lymphoma: clinical, histological, virological, and genetic features

Clinicopathologic Manifestations of Epstein-Barr Virus—Associated Cutaneous Lymphoproliferative Disorders

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